HCV Drugs in Development

Drug Class	Company	Drug Name	Alt Name	Drug Status	Notes	AIDS#
A3 Adenosine receptor Agonist	Can-Fite BioPharma	CF102		Phase I/II	Completed
Adjunct	Romark	Nitazoxanide		Phase II/III	Completed
Capase Inhibitor	Conatus Pharmaceuticals Inc; Pfizer	PF-03491390	IDN-6556	Phase II	Completed
Capase Inhibitor	Gilead Sciences	GS-9450		Phase IIa	Completed
Cyclophilin B Inhibitor	Aventis; Scynexis	SCY-635		Phase II	Completed	189067
Cyclophilin B Inhibitor	Novartis Pharmaceuticals	NIM-811	[Me-Ile-4]Cyclosporin A; SDZ-811	Phase II	Completed	006796
Cyclophilin D Inhibitor	Novartis Pharmaceuticals	Alisporivir	Debio-025; DEB025	Phase III	Ongoing, Not Recruiting	268533
DGAT1 inhibitor	Novartis Pharmaceuticals	LCQ-908	LCQ-908-ABA.002	Phase II	Terminated
E2 glycoprotein MAb	Mass Biologics	MBL-HCV1		Phase II	Recruiting
HCV Entry Inhibitor	ItherX	ITX-5061		Phase I	Completed
HCV Nucleoside Inhibitor	Hoffmann-La Roche	RO-5428029		Phase I	Completed
HCV Polymerase Inhibitor	Viropharma; Pfizer; Gilead Sciences	HCV-796		Phase II	Completed	376743
HCV Polymerase Inhibitor	Pfizer	Filibuvir	PF-00868554	Phase II	Completed	490021
HCV Polymerase Inhibitor	Vertex Pharmaceuticals Incorporated	Lomibuvir	VX-222; VCH-222	Phase II	Ongoing, Not Recruiting
HCV Polymerase Inhibitor	Roche	Balapiravir	R-1626; RO-4588161	Phase II	Completed
HCV Polymerase Inhibitor	Abbott	ABT-333		Phase III	Not Yet Recruiting
HCV Polymerase Inhibitor	Abbott	ABT-072		Phase II	Completed
HCV Polymerase Inhibitor	Boehringer Ingelheim Pharmaceuticals	BI-207127		Phase II	Ongoing, Not Recruiting
HCV Polymerase Inhibitor	Idenix Pharmaceuticals	IDX-184		Phase II	Completed
HCV Polymerase Inhibitor	Pharmasset/Roche	Mericitabine	RG-7128; RO-5024048	Phase II	Recruiting
HCV Polymerase Inhibitor	Idenix Pharmaceuticals	Valopicitabine	NM-283	Phase II	Completed	418137
HCV Polymerase Inhibitor	Medivir; Tibotec Pharmaceuticals	TMC-649128		Phase I	Terminated
HCV Polymerase Inhibitor	Gilead Sciences	Tegobuvir	GS-9190; GS-333126	Phase II	Ongoing, Not Recruiting	485775
HCV Polymerase Inhibitor	Hoffmann-La Roche	Setrobuvir	ANA-598	Phase II	Completed
HCV Polymerase Inhibitor	Merck	MK-3281		Phase I	Terminated	510563
HCV Polymerase Inhibitor	Gilead Sciences	GS 6620		Phase I	Completed
HCV Polymerase Inhibitor	Achillion	ACH-3102		Phase II	Recruiting
HCV Polymerase Inhibitor	Alios	ALS-2200	VX-135	Phase I	Recruiting
HCV Polymerase Inhibitor	Gilead Sciences	GS-9669		Phase II	Recruiting
HCV Polymerase Inhibitor	Gilead Sciences	Sofosbuvir	GS 7977; PSI-7977	Phase III	Recruiting
HCV Protease Inhibitor	Medivir; Tibotec Pharmaceuticals	Simeprevir	TMC-435; TMC-435350	Phase III	Ongoing, Not Recruiting	489101
HCV Protease Inhibitor	Boehringer Ingelheim Pharmaceuticals	Faldaprevir	BI-201335	Phase III	Ongoing, Not Recruiting	506842
HCV Protease Inhibitor	Schering-Plough	Narlaprevir	SCH-900518	Phase II/III	Invitation Only	501790
HCV Protease Inhibitor	Idenix Pharmaceuticals	IDX-320		Phase I	Completed
HCV Protease Inhibitor	Rottapharm Madaus	Silibinin sodium hemisuccinate	Legalon Sil; SHS	Phase II	Recruiting
HCV Protease Inhibitor	Presido	PPI-668		Phase I	Ongoing, Not Recruiting
HCV Protease Inhibitor	Intermune; Roche	Danoprevir	RG-7227; ITMN-191	Phase II	Recruiting	488730
HCV Protease Inhibitor	TaiGen Biotechnology	TG-2349		Phase I	Recruiting
HCV Protease Inhibitor	Bristol-Myers Squibb	Asunaprevir	BMS-650032	Phase III	Recruiting	501741
HCV Protease Inhibitor	Bristol-Myers Squibb	BMS-791325		Phase II	Ongoing, Not Recruiting
HCV Protease Inhibitor	Merck	Vaniprevir	MK-7009	Phase III	Ongoing, Not Recruiting	496721
HCV Protease Inhibitor	Vertex Pharmaceuticals Incorporated	VX-985		Phase I	Completed
HCV Protease Inhibitor	Gilead Sciences	GS-9256		Phase IIb	Ongoing, Not Recruiting
HCV Protease Inhibitor	Abbott	ABT-450		Phase III	Not Yet Recruiting
HCV Protease Inhibitor	Merck	MK-5172		Phase II	Ongoing, Not Recruiting	501731
HCV Replication Inhibitor	Romark	Alinia™	Nitazoxanide	Phase II/III	Recruiting	057131
HCV Replication Inhibitor	Arrow Theraputics	AZD-7295		Phase I	Completed	506699
HCV Replication Inhibitor	Bristol-Myers Squibb	Daclatasvir	BMS-790052	Phase III	Recruiting	503558
HCV Replication Inhibitor	Novartis Pharmaceuticals	Zalbin™	Albinterferon; Albuferon; alb-IFN	Phase II	Completed	184128
HCV Replication Inhibitor	Eiger BioPharmaceuticals	Clemizole		Phase Ib	Completed	033090
HCV Replication Inhibitor	ZymoGenetics	PEG-rIL-29	(man-made IL-29); PEG_IFN_lambda	Phase II	Ongoing, Not Recruiting
HCV Replication Inhibitor	Presidio Pharmaceuticals	PPI-461		Phase Ib	Completed	501737
HCV Replication Inhibitor	Valeant Pharmaceuticals	Taribavirin	Viramidine; Ribamidine; ICN-3142	Phase III	Completed	000198
HCV Replication Inhibitor	Achillion	Sovaprevir	ACH-0141625; ACH-1625; Prodrug of ACH-1095	Phase II	Ongoing, Not Recruiting
HCV Replication Inhibitor	Bristol-Myers Squibb	BMS-824393		Phase IIa	Completed
HCV Replication Inhibitor	Abbott	ABT-267		Phase III	Not Yet Recruiting
HCV Replication Inhibitor	GlaxoSmithKline	GSK2336805		Phase II	Recruiting
HCV Replication Inhibitor	Gilead Sciences	GS-5885		Phase III	Recruiting
HCV Replication Inhibitor	Idenix Pharmaceuticals	IDX-719	IDX-380	Phase I/II	Completed
Immune Response Modulator	Anadys Pharmaceuticals	ANA-773		Phase I	Completed
Immune Response Modulator	Dynavax Technologies Corporation	SD-101		Phase I	Completed
Immune Response Modulator	Idera Pharmaceuticals, Inc.	IMO-2125		Phase I	Completed
Immunomodulator	Cytheris SA	CYT107	Glyco-r-hIL-7; Interleukin-7	Phase I/IIa	Ongoing, Not Recruiting	398475
Immunomodulator and Anti-inflammatory	Novelos Therapeutics	NOV-205	BAM-205 (Glutathione and Inosine)	Phase II	Completed
Interferon alpha 2b agonist	Biolex Therapeutics	Locteron™	Controlled Release Interferon alpha 2a	Phase IIb	Completed	001582
MMP inhibitor/Anti-fibrogenic	Conatus Pharmaceuticals Inc.	CTS-1027		Phase II	Completed
MicroRNA Inhibitor	Santaris Pharma	Miravirsen	Anti-miR-122; SPC-3649	Phase II	Completed
Natural Product	PhytoHealth Corporation	PHN-121		Phase I/II	Unknown
PD-1 receptor MAb	Bristol-Myers Squibb	Nivolumab	MDX-1106; BMS-936558; ONO-4538	Phase I	Completed
Stimulates T-helper cells	SciClone Pharmaceuticals	Golotimod	SCV-07; (?-D-glutamyl-L-tryptophan)	Phase II	Completed	346667
Virucidal/Anti-phosphotidylserine	Peregrine Pharmaceuticals	Tarvacin™	Bavituximab	Phase I/II	Completed
toll-like receptor-7 agonist	Gilead Sciences	GS-9620		Phase 1	Ongoing, Not Recruiting

Some useful sites where additional information on these drugs may be found:

Division of AIDS Anti-HIV/OI/TB Therapeutics Database

HCV Drugs in Development