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HCV Drugs in Development


Drug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
A3 Adenosine receptor AgonistCan-Fite BioPharmaCF102CI-IB-MECAPhase 1/2Completed 
Antihistamine Chlorcyclizine Phase 1Recruiting 033660
Caspase InhibitorGilead SciencesGS-9450 Phase 2Completed 
Caspase InhibitorConatus Pharmaceuticals Inc; PfizerPF-03491390IDN-6556Phase 2Completed 
Cyclophilin B InhibitorNovartis PharmaceuticalsNIM-811[Me-Ile-4] Cyclosporin A; SDZ-811Phase 2Completed 006796
Cyclophilin B InhibitorAventis; ScynexisSCY-635 Phase 2Completed 189067
Cyclophilin D InhibitorNovartis PharmaceuticalsAlisporivirDebio-025; DEB025Phase 3Terminated 268533
DGAT1 inhibitorNovartis PharmaceuticalsLCQ-908LCQ-908-ABA.002Phase 2Terminated 
E2 glycoprotein MAbMass BiologicsMBL-HCV1 Phase 2Ongoing, Not Recruiting 
HCV Entry InhibitorItherXITX-5061 Phase 1Completed 
HCV Nucleoside InhibitorHoffmann-La RocheRO-5428029 Phase 1Completed 
HCV Polymerase InhibitorAbbott (AbbVie)ABT-072 Phase 2Completed 
HCV Polymerase InhibitorAchillionACH-3102 Phase 2Completed 565907
HCV Polymerase InhibitorAlios BioPharmaAL-335 Phase 1Recruiting 
HCV Polymerase InhibitorAliosALS-2200VX-135Phase 2Completed 
HCV Polymerase InhibitorRocheBalapiravirR-1626; RO-4588161Phase 2Completed 
HCV Polymerase InhibitorBoehringer Ingelheim PharmaceuticalsBILB 1941 Phase 1/2Completed 
HCV Polymerase InhibitorAbbott (AbbVie)DasabuvirABT-333Phase 3Recruiting 
HCV Polymerase InhibitorBoehringer Ingelheim PharmaceuticalsDeleobuvirBI-207127Phase 3Completed 
HCV Polymerase InhibitorPfizerFilibuvirPF-00868554Phase 2Completed 490021
HCV Polymerase InhibitorGilead SciencesGS 6620 Phase 1Completed 558193
HCV Polymerase InhibitorGilead SciencesGS-9669 Phase 2Completed 543505
HCV Polymerase InhibitorIdenix PharmaceuticalsIDX 21459 Phase 1Terminated 
HCV Polymerase InhibitorIdenix PharmaceuticalsIDX-184 Phase 2Completed 556345
HCV Polymerase InhibitorVertex Pharmaceuticals IncorporatedLomibuvirVX-222; VCH-222Phase 2Completed 543506
HCV Polymerase InhibitorPharmasset/RocheMericitabineRG-7128; RO-5024048Phase 2Completed 550380
HCV Polymerase InhibitorMerckMK-3281 Phase 1Terminated 510563
HCV Polymerase InhibitorMerckMK-8408 Phase 2Recruiting 
HCV Polymerase InhibitorViropharma; Pfizer; Gilead SciencesNesbuvirHCV-796Phase 2Completed 376743
HCV Polymerase InhibitorHoffmann-La RocheSetrobuvirANA-598Phase 2Completed 497335
HCV Polymerase InhibitorTheravance BiopharmaTD-6450TF-6450Phase 1Completed 
HCV Polymerase InhibitorGilead SciencesTegobuvirGS-9190; GS-333126Phase 2Completed 485775
HCV Polymerase InhibitorMedivir; Tibotec PharmaceuticalsTMC-649128 Phase 1Terminated 
HCV Polymerase InhibitorIdenix PharmaceuticalsValopicitabineNM-283Phase 2Completed 418137
HCV Protease InhibitorBoehringer Ingelheim PharmaceuticalsCiluprevirBILN 2061Phase 2Completed 195599
HCV Protease InhibitorIntermune; RocheDanoprevirRG-7227; ITMN-191Phase 2Completed 488730
HCV Protease InhibitorBristol-Myers SquibbAsunaprevirBMS-650032Phase 3Ongoing, Not Recruiting 501741
HCV Protease InhibitorAbbott (AbbVie)ABT-493 Phase 2Recruiting 
HCV Protease InhibitorAbbott (AbbVie)ABT-450 Phase 3Recruiting 
HCV Protease InhibitorBristol-Myers SquibbBeclabuvirBMS-791325Phase 3Ongoing, Not Recruiting 493957
HCV Protease InhibitorVertex Pharmaceuticals IncorporatedVX-985 Phase 1Completed 
HCV Protease InhibitorGilead SciencesVedroprevirGS-9451Phase 2Completed 551450
HCV Protease InhibitorMerckVanihep™(Japan)Vaniprevir; MK-7009Phase 3Completed 496721
HCV Protease InhibitorPresidoRavidasvirPPI-668Phase 2/3Recruiting 565898
HCV Protease InhibitorSchering-PloughNarlaprevirSCH-900518Phase 2Completed 501790
HCV Protease InhibitorRottapharm MadausLegalon™ Sil; SHS; Silibinin sodium hemisuccinate Phase 2/3Terminated 513548
HCV Protease InhibitorIdenix PharmaceuticalsIDX-320 Phase 1/2Completed 
HCV Protease InhibitorGilead SciencesGS-9256 Phase 2bCompleted 
HCV Protease InhibitorTaiGen BiotechnologyFuraprevirTG-2349Phase 2Not Yet Recruiting 
HCV Protease InhibitorBoehringer Ingelheim PharmaceuticalsFaldaprevirBI-201335Phase 3Completed 506842
HCV Protease Inhibitor MerckGrazoprevirMK-5172Phase 3Recruiting 501731
HCV Replication InhibitorZymoGenetics; Bristol-Myers SquibbBMS-914143; PEG-rIL-29(man-made IL-29); PEG_IFN_lambda; BMS-914143Phase 3Completed 
HCV Replication InhibitorBristol-Myers SquibbBMS-824393 Phase 2aWithdrawn 
HCV Replication InhibitorArrow TheraputicsAZD-7295 Phase 2Completed 506699
HCV Replication InhibitorRomarkAlinia™Nitazoxanide; Xerovirin-CPhase 2/3Completed 057131
HCV Replication InhibitorAbbott (AbbVie)ABT-530 Phase 2Active, Not Recruiting 
HCV Replication InhibitorBristol-Myers SquibbDaclatasvirBMS-790052NDA2015 503558
HCV Replication InhibitorNovartis PharmaceuticalsEDP-239 Phase 1Active, Not Recruiting 
HCV Replication InhibitorMerckElbasvirMK-8742Phase 2/3Recruiting 
HCV Replication InhibitorGilead SciencesGS-5816 Phase 2Not Yet Recruiting 
HCV Replication InhibitorGilead SciencesGS-9857 Phase 2Recruiting 
HCV Replication InhibitorGlaxoSmithKlineGSK2336805JNJ56914845Phase 2aCompleted 563249
HCV Replication InhibitorGilead SciencesLedipasvirGS-5885Phase 3Recruiting 557593
HCV Replication InhibitorAbbott (AbbVie)OmbitasvirABT-267Phase 3Recruiting 541999
HCV Replication InhibitorPresidio Pharmaceuticals; AscletisPPI-461 Phase 1b Completed 501737
HCV Replication InhibitorIdenix PharmaceuticalsSamatasvirIDX-719; IDX-380; MK-1894Phase 1/2Completed 564114
HCV Replication InhibitorAchillionSovaprevirACH-0141625; ACH-1625; Prodrug of ACH-1095Phase 2Completed 491583
HCV Replication InhibitorEiger BioPharmaceuticalsClemizole Phase 1bCompleted 033090
HCV Replication InhibitorNovartis PharmaceuticalsZalbin™Albinterferon; Albuferon; alb-IFNPhase 2Completed 184128
HCV Replication InhibitorValeant Pharmaceuticals; Kadmon Pharmaceuticals TaribavirinViramidine; Ribamidine; ICN-3142Phase 3Completed 000198
ImmunomodulatorIdera Pharmaceuticals, Inc.IMO-2125 Phase 1Completed 
ImmunomodulatorDynavax Technologies CorporationSD101 Phase 1Completed 
ImmunomodulatorCytheris SACYT107Glyco-r-hIL-7; Interleukin-7Phase 1/2aCompleted 398475
ImmunomodulatorAnadys PharmaceuticalsANA-773RO-6864018Phase 1Completed 
ImmunomodulatorBiocadAlgeronCepeginterferon alfa 2bPhase 3Recruiting 
Immunomodulator and Anti-inflammatory Novelos Therapeutics; Cellectar BiosciencesNOV-205BAM-205 (Glutathione and Inosine); MolixanPhase 2Completed 
Interferon alpha 2b agonistBiolex TherapeuticsLocteron™Controlled Release Interferon alpha 2aPhase 3Not Yet Recruiting 001582
MMP inhibitor/Anti-fibrogenicConatus Pharmaceuticals Inc.CTS-1027 Phase 2Completed 
MicroRNA InhibitorSantaris PharmaMiravirsen Anti-miR-122; SPC-3649Phase 2Ongoing, Not Recruiting 
Natural ProductPhytoHealth CorporationPHN-121 Phase 1/2Terminated 
Not SpecifiedNovartis PharmaceuticalsBZF-961 Phase 1/2Completed 
PD-1 receptor MAbBristol-Myers SquibbNivolumabMDX-1106; BMS-936558; ONO-4538Phase 1Completed 
Stimulates T-helper cellsSciClone PharmaceuticalsGolotimodSCV-07; (gamma-glutamyl-L-tryptophan)Phase 2Completed 346667
UnknownMerckMK-1075 Phase 1Not Yet Recruiting 
UnknownMerckMK-2248 Phase 1Completed 
UnknownMerckMK-7680 Phase 1Recruiting 
Virucidal/Anti-phosphotidylserinePeregrine PharmaceuticalsTarvacin™BavituximabPhase 1/2Completed 
toll-like receptor-7 agonistGilead SciencesGS-9620 Phase 1Completed 

Last Updated: April 2015