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HCV Drugs in Development


Drug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
A3 Adenosine receptor AgonistCan-Fite BioPharmaCF102 Phase I/IICompleted
Capase InhibitorConatus Pharmaceuticals Inc; PfizerPF-03491390IDN-6556Phase IIRecruiting
Capase InhibitorGilead SciencesGS-9450 Phase IIaCompleted
Cyclophilin B InhibitorNovartis PharmaceuticalsNIM-811[Me-Ile-4]Cyclosporin A; SDZ-811Phase IICompleted 006796
Cyclophilin B InhibitorAventis; ScynexisSCY-635 Phase IICompleted 189067
Cyclophilin D InhibitorNovartis PharmaceuticalsAlisporivirDebio-025; DEB025Phase IIITerminated 268533
DGAT1 inhibitorNovartis PharmaceuticalsLCQ-908LCQ-908-ABA.002Phase IITerminated
E2 glycoprotein MAbMass BiologicsMBL-HCV1 Phase IIRecruiting
HCV Entry InhibitorItherXITX-5061 Phase ICompleted
HCV Nucleoside InhibitorHoffmann-La RocheRO-5428029 Phase ICompleted
HCV Polymerase InhibitorRocheBalapiravirR-1626; RO-4588161Phase IICompleted
HCV Polymerase InhibitorAbbottABT-333 Phase IIIOngoing, Not Recruiting
HCV Polymerase InhibitorGilead SciencesGS 6620 Phase ICompleted
HCV Polymerase InhibitorBoehringer Ingelheim PharmaceuticalsBI-207127 Phase IIIRecruiting
HCV Polymerase InhibitorVertex Pharmaceuticals IncorporatedLomibuvirVX-222; VCH-222Phase IIOngoing, Not Recruiting 543506
HCV Polymerase InhibitorPfizerFilibuvirPF-00868554Phase IICompleted 490021
HCV Polymerase InhibitorViropharma; Pfizer; Gilead SciencesHCV-796 Phase IICompleted 376743
HCV Polymerase InhibitorIdenix PharmaceuticalsIDX-184 Phase IIOngoing, Not Recruiting
HCV Polymerase InhibitorPharmasset/RocheMericitabineRG-7128; RO-5024048Phase IIOngoing, Not Recruiting 550380
HCV Polymerase InhibitorIdenix PharmaceuticalsValopicitabineNM-283Phase IICompleted 418137
HCV Polymerase InhibitorMedivir; Tibotec PharmaceuticalsTMC-649128 Phase ICompleted
HCV Polymerase InhibitorGilead SciencesTegobuvirGS-9190; GS-333126Phase IIOngoing, Not Recruiting 485775
HCV Polymerase InhibitorHoffmann-La RocheSetrobuvirANA-598Phase IICompleted 497335
HCV Polymerase InhibitorMerckMK-3281 Phase ITerminated 510563
HCV Polymerase InhibitorAbbottABT-072 Phase IICompleted
HCV Polymerase InhibitorAchillionACH-3102 Phase IIRecruiting
HCV Polymerase InhibitorAliosALS-2200VX-135Phase IOngoing, Not Recruiting
HCV Polymerase InhibitorGilead SciencesGS-9669 Phase IIRecruiting 543505
HCV Protease InhibitorGilead SciencesGS-9256 Phase IIbOngoing, Not Recruiting
HCV Protease InhibitorBristol-Myers SquibbBMS-791325 Phase IIINot Yet Recruiting 493957
HCV Protease InhibitorMerckVaniprevirMK-7009Phase IIICompleted 496721
HCV Protease InhibitorRottapharm MadausLegalon™ Sil; SHS; Silibinin sodium hemisuccinate Phase IIICompleted 513548
HCV Protease InhibitorSchering-PloughNarlaprevirSCH-900518Phase II/IIIOngoing, Not Recruiting 501790
HCV Protease InhibitorIdenix PharmaceuticalsIDX-320 Phase ICompleted
HCV Protease InhibitorVertex Pharmaceuticals IncorporatedVX-985 Phase ICompleted
HCV Protease InhibitorPresidoPPI-668 Phase IIRecruiting
HCV Protease InhibitorTaiGen BiotechnologyTG-2349 Phase IRecruiting
HCV Protease InhibitorIntermune; RocheDanoprevirRG-7227; ITMN-191Phase IIRecruiting 488730
HCV Protease InhibitorGilead SciencesVedroprevirGS-9451Phase IIOngoing, Not Recruiting 551450
HCV Protease InhibitorAbbottABT-450 Phase IIIOngoing, Not Recruiting
HCV Protease InhibitorBoehringer Ingelheim PharmaceuticalsFaldaprevirBI-201335 Phase IIIOngoing, Not Recruiting 506842
HCV Protease InhibitorBristol-Myers SquibbAsunaprevirBMS-650032Phase IIIOngoing, Not Recruiting 501741
HCV Protease Inhibitor MerckMK-5172 Phase IIOngoing, Not Recruiting 501731
HCV Replication InhibitorRomarkAlinia™NitazoxanidePhase II/IIIOngoing, Not Recruiting 057131
HCV Replication InhibitorArrow TheraputicsAZD-7295 Phase ICompleted 506699
HCV Replication InhibitorBristol-Myers SquibbDaclatasvirBMS-790052Phase IIIOngoing, Not Recruiting 503558
HCV Replication InhibitorNovartis PharmaceuticalsZalbin™Albinterferon; Albuferon; alb-IFNPhase IICompleted 184128
HCV Replication InhibitorEiger BioPharmaceuticalsClemizole Phase IbCompleted 033090
HCV Replication InhibitorZymoGeneticsPEG-rIL-29(man-made IL-29); PEG_IFN_lambdaPhase IIUnknown
HCV Replication InhibitorPresidio PharmaceuticalsPPI-461 Phase Ib Completed 501737
HCV Replication InhibitorValeant Pharmaceuticals TaribavirinViramidine; Ribamidine; ICN-3142Phase IIICompleted 000198
HCV Replication InhibitorAchillionSovaprevirACH-0141625; ACH-1625; Prodrug of ACH-1095Phase IIRecruiting 491583
HCV Replication InhibitorBristol-Myers SquibbBMS-824393 Phase IIaWithdrawn
HCV Replication InhibitorAbbottABT-267 Phase IIIOngoing, Not Recruiting 541999
HCV Replication InhibitorGlaxoSmithKlineGSK2336805 Phase IIOngoing, Not Recruiting
HCV Replication InhibitorGilead SciencesLedipasvirGS-5885Phase IIIOngoing, Not Recruiting
HCV Replication InhibitorIdenix PharmaceuticalsIDX-719IDX-380Phase IIRecruiting
Immune Response ModulatorAnadys PharmaceuticalsANA-773 Phase ICompleted
Immune Response ModulatorDynavax Technologies CorporationSD-101 Phase ICompleted
Immune Response ModulatorIdera Pharmaceuticals, Inc.IMO-2125 Phase ICompleted
ImmunomodulatorCytheris SACYT107Glyco-r-hIL-7; Interleukin-7Phase I/IIaOngoing, Not Recruiting 398475
Immunomodulator and Anti-inflammatory Novelos TherapeuticsNOV-205BAM-205 (Glutathione and Inosine)Phase IICompleted
Interferon alpha 2b agonistBiolex TherapeuticsLocteron™Controlled Release Interferon alpha 2aPhase IIbCompleted 001582
MMP inhibitor/Anti-fibrogenicConatus Pharmaceuticals Inc.CTS-1027 Phase IICompleted
MicroRNA InhibitorSantaris PharmaMiravirsen Anti-miR-122; SPC-3649Phase IIOngoing, Not Recruiting
Natural ProductPhytoHealth CorporationPHN-121 Phase I/IITerminated
PD-1 receptor MAbBristol-Myers SquibbNivolumabMDX-1106; BMS-936558; ONO-4538Phase ICompleted
Stimulates T-helper cellsSciClone PharmaceuticalsGolotimodSCV-07; (gamma-glutamyl-L-tryptophan)Phase IICompleted 346667
Virucidal/Anti-phosphotidylserinePeregrine PharmaceuticalsTarvacin™BavituximabPhase I/IICompleted
toll-like receptor-7 agonistGilead SciencesGS-9620 Phase 1Completed

Last Updated: January 2014