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Protozoal Drugs in Development


OrganismDrug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Plasmodium spp.Antimalarial AminoquinolineSanofiFerroquineSR-97193Phase 2Terminated 517288
Plasmodium spp.Antimalarial EndoperoxidesGlaxoSmithKlineTafenoquine; EtaquineWR 238605; SB-252263Phase 3Not Yet Recruiting 006901
Plasmodium spp.Antimalarial SpiroindoloneNovartisKAE-609NITD-609Phase 2Ongoing, Not Recruiting 
Plasmodium spp.Antimalarial TrioxolaneMedicines for Malaria VentureArtefenomelOZ-439; MMV-08/1019Phase 2bRecruiting 
Plasmodium spp.Antimalarial aminopyridineMedicines for Malaria VentureMMV390048 Phase 1Recruiting 
Plasmodium spp.Aspartic endopeptidase inhibitorActelion PharmaceuticalsACT-451840 Phase 1Recruiting 
Plasmodium spp.CombinationPoliclinique Medicale UniversitaireCotrifazidRifampicin and Cotrimoxazole and Isoniazid Phase 2Terminated 
Plasmodium spp.CombinationPfizerAzithromycin and ChloroquineAZCQ; Zithromax and Chloroquine; Zmax and ChloroquinePhase 3Terminated 
Plasmodium spp.CombinationHolley Pharm; Holleykin PharmEurartesim; Artekin™; Duocotecxin™Dihydroartemisinin and PiperaquinePhase 3Recruiting 
Plasmodium spp.CombinationJomma PharmaFosmidomycin-Piperaquine Phase 2aOngoing, Not Recruiting 
Plasmodium spp.CombinationJomaa PharmaFosclin; JP-01Clindamycin and FosmidomycinPhase 3Completed 
Plasmodium spp.DNA Synthesis InhibitorPfizer; Mission PharmacalTindamax™; Fasigyn™; Simplotan™TinidazolePhase 2Completed 007940
Plasmodium spp.Dihydroorotate dehydrogenase inhibitorMedicines for Malaria Venture; TakedaDSM265 Phase 2aRecruiting 
Plasmodium spp.Electron Transport Chain InhibitorGlaxoSmithKlineGSK932121 Phase 1Terminated 
Plasmodium spp.Hemozoin InhibitorTulane University Health CenterAQ-13AminoquinolinePhase 2Recruiting 532415
Plasmodium spp.Inhibition of Phospholipid Metabolism Sanofi-AventisSAR97276A1,12-Bis[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium]dodecane dibromidePhase 2Terminated 
Toxoplasma gondiiProtein Synthesis Inhibitor (binds to 50S subunit)Rhone-Poulenc PharmaceuticalsRovamycine™SpiramycinPhase 3Recruiting 007350
Trypanosoma cruziMembrane DisruptorDrugs for Neglected Diseases; Eisai Co., Ltd.E1224Prodrug of RavuconazolePhase 2Unknown 057176

Last Updated: April 2015