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Protozoal Drugs in Development


OrganismDrug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Plasmodium spp.Antimalarial AminoquinolineSanofiFerroquineSR-97193Phase IITerminated 517288
Plasmodium spp.Antimalarial EndoperoxidesGlaxoSmithKlineTafenoquine; EtaquineWR 238605; SB-252263Phase IIOngoing, Not Recruiting 006901
Plasmodium spp.Antimalarial SpiroindoloneNovartisKAE-609NITD-609Phase IIRecruiting
Plasmodium spp.Antimalarial TrioxolaneMedicines for Malaria VentureOZ-439MMV-08/1019Phase IIRecruiting
Plasmodium spp.CombinationPoliclinique Medicale UniversitaireCotrifazidRifampicin and Cotrimoxazole and Isoniazid Phase IITerminated
Plasmodium spp.CombinationPfizerAzithromycin and ChloroquineAZCQ; Zithromax and Chloroquine; Zmax and ChloroquinePhase IIIOngoing, Not Recuriting
Plasmodium spp.CombinationHolley Pharm; Holleykin PharmEurartesim; Artekin™; Duocotecxin™Dihydroartemisinin and PiperaquinePhase IIIRecruiting
Plasmodium spp.CombinationJomaa PharmaFosclin; JP-01Clindamycin and FosmidomycinPhase IIICompleted
Plasmodium spp.DNA Synthesis InhibitorPfizer; Mission PharmacalTindamax™; Fasigyn™; Simplotan™TinidazolePhase IICompleted 007940
Plasmodium spp.Electron Transport Chain InhibitorGlaxoSmithKlineGSK932121 Phase ITerminated (Toxicity)
Plasmodium spp.Hemozoin InhibitorTulane University Health CenterAQ-13AminoquinolinePhase IIRecruiting 532415
Plasmodium spp.Inhibition of Phospholipid Metabolism Sanofi-AventisSAR97276A1,12-Bis[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium]dodecane dibromidePhase IITerminated
Toxoplasma gondiiProtein Synthesis Inhibitor (binds to 50S subunit)Rhone-Poulenc PharmaceuticalsRovamycine™SpiramycinPhase IIIRecruiting 007350
Trypanosoma cruziMembrane DisruptorBristol-Myers SquibbRavuconazoleBMS-207147; ER-30346Phase I/IIUnknown Status 057176

Last Updated: January 2014