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Organism

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Chemical Name: Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-, (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-			Synonyms Rifabutine Ansamycin LM427 RBT LM-427 LM 427 Mycobutin Rifabutin RBU Alfacid Assatipin Ansatipine		AIDS# 000121
					Links to ChemID Plus by CAS# 72559-06-9
					Links to PubChem by AIDS# 000121
LOG P FROM SOURCE 8903
C46 H62 N4 O11		MW: 847.01			Links to PubMed by CAS#
H-bond donors: 5	H-bond acceptors: 15	PHIA (Flexible Bonds): 13.82	Calc. LogP (MDL QSAR): 5.23
Company: FARMITALIA CARLO ERBA/PHARMACIA & UPJOHN			Calc. LogP (KowWin): 4.31
Lines of Data: 10	Lines of Data: 1	Lines of Data: 959	TB Min MIC 0.0025 ug/mL	TB Min IC50 < 0.12 ug/mL	Links to NIST by AIDS#
Number of References: 4	Number of References: 1	Number of References: 119	Lipinski: 1 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; RIFAMYCINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS; MYCINS

Chemical Name: L-threo-.alpha.-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-			Synonyms Clindamycin Cleocin U-21251 7(S)-Chloro-7-deoxylincomycin Sobelin Dalacine Dalacin C Chlolincocin Clinimycin		AIDS# 000227
					Links to ChemID Plus by CAS# 18323-44-921462-39-5 [HYDROCHLORIDE] 58207-19-5 [HYDROCHLORIDE, MONOHYDRATE]
					Links to PubChem by AIDS# 000227
HYDROCHLORIDE SALT; OR HYDROCHLORIDE SALT, MONOHYDRATE
C18 H33 Cl N2 O5 S		MW: 424.99			Links to PubMed by CAS#
H-bond donors: 4	H-bond acceptors: 9	PHIA (Flexible Bonds): 8.83	Calc. LogP (MDL QSAR): 2.11
Company: PHARMACIA & UPJOHN			Calc. LogP (KowWin): 2.01
Anti-HIV Cellular data: 0	Lines of Data: 1	Lines of Data: 84	TB Min MIC < 64 ug/mL	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 1	Number of References: 17	Lipinski: 4 (Score, out of 4)
Classes: ANTIBACTERIALS; SEMI-SYNTHETICS; MYCINS; ANTIMYCOBACTERIALS

Chemical Name: 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)			Synonyms Doxycycline Vibramycin (monohydrate) GS-3065 (monohydrate) Vivox (Hyclate) AB08 (Fosfatex) DMSC (Fosfatex) Monodox (monohydrate) NSC633557 (HYDROCHLORIDE)		AIDS# 000242
					Links to ChemID Plus by CAS# 10592-13-9 [HYDROCHLORIDE] 24390-14-5 [HYCLATE] 83038-87-3 [FOSFATEX] 564-25-017086-28-1 [MONOHYDRATE]
					Links to PubChem by AIDS# 000242
MONOHYDRATE; OR HYDROCHLORIDE; HYCLATE (HYDROCHLORIDE/ETHANOL 2/1); FOSFATEX (SODIUM TRIHYDROGEN METAPHOSPHATE, H3NAP4012, 3:1)
C22 H24 N2 O8		MW: 444.44			Links to PubMed by CAS#
H-bond donors: 6	H-bond acceptors: 10	PHIA (Flexible Bonds): 5.1	Calc. LogP (MDL QSAR): 0.67
Company: PFIZER			Calc. LogP (KowWin): -1.36
Lines of Data: 8	Lines of Data: 1	Lines of Data: 146	TB Min MIC 1 ug/mL	TB Min IC50	Links to NIST by AIDS#
Number of References: 3	Number of References: 1	Number of References: 17	Lipinski: 3 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; SEMI-SYNTHETICS; ANTIBACTERIALS; TETRACYCLINES; MYCINS; ANTIMYCOBACTERIALS

Chemical Name: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-			Synonyms 9-Fluoro-2, 3-dihydro-3(S)-methyl-10-[3(S)-N, N-dimethylamino-1-pyrrolidinyl]-7-oxo-7H-pyrido[1, 2, 3-de][1, 4]benzoxazine-6-carbocylic acid		AIDS# 001111
					Links to ChemID Plus by CAS# 292865-93-1
					Links to PubChem by AIDS# 001111

C19 H22 F N3 O4		MW: 375.4			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 8	PHIA (Flexible Bonds): 4.48	Calc. LogP (MDL QSAR): 0.46
Company: DAIICHI PHARMACEUTICAL (TOKYO)			Calc. LogP (KowWin): 0.22
Anti-HIV Cellular data: 0	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC 3 ug/mL	TB Min IC50	Links to NIST by AIDS#
Number of References: 0	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; FLUOROQUINOLONES; ANTIBACTERIALS; PYRIDOBENZOXAZINES; ANTIMYCOBACTERIALS

Chemical Name: 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-			Synonyms Minocline Minocycline Minocin (Hydrochloride) Vectrin (Hydrochloride) NSC141993		AIDS# 001299
					Links to ChemID Plus by CAS# 13614-98-7 [MONOHYDROCHLORIDE] 10118-90-8
					Links to PubChem by AIDS# 001299
OR HYDROCHLORIDE SALT
C23 H27 N3 O7		MW: 457.48			Links to PubMed by CAS#
H-bond donors: 5	H-bond acceptors: 10	PHIA (Flexible Bonds): 5.53	Calc. LogP (MDL QSAR): 1.37
Company: WYETH-AYERST (LEDERLE); PARKE-DAVIS			Calc. LogP (KowWin): -0.42
Lines of Data: 12	Lines of Data: 1	Lines of Data: 137	TB Min MIC 0.5 ug/mL	TB Min IC50	Links to NIST by AIDS#
Number of References: 3	Number of References: 1	Number of References: 20	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; SEMI-SYNTHETICS; ANTIBACTERIALS; TETRACYCLINES; ANTIMYCOBACTERIALS

Chemical Name: (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid			Synonyms Ofloxacin DL-8280 HOE 280 Floxin Exocin Ocuflox Zanocin OFLX OFX		AIDS# 001339
					Links to ChemID Plus by CAS# 82419-36-1
					Links to PubChem by AIDS# 001339
RACEMIC MIXTURE
C18 H20 F N3 O4		MW: 361.37			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 8	PHIA (Flexible Bonds): 4.25	Calc. LogP (MDL QSAR): 0.11
Company: DAIICHI PHARM; ORTHO-MCNEIL			Calc. LogP (KowWin): -0.2
Lines of Data: 4	Anti-HIV Enzyme data: 0	Lines of Data: 906	TB Min MIC 0.0115 ug/mL	TB Min IC50 < 0.25 ug/mL	Links to NIST by AIDS#
Number of References: 3	Number of References: 0	Number of References: 116	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; PYRIDOBENZOXAZINES; OFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-			Synonyms Norfloxacin MK-366 Noroxin Chibroxin Norfloxacine		AIDS# 001991
					Links to ChemID Plus by CAS# 70458-96-768077-27-0 [HCL]
					Links to PubChem by AIDS# 001991

C16 H18 F N3 O3		MW: 319.33			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 7	PHIA (Flexible Bonds): 4.36	Calc. LogP (MDL QSAR): -0.65
Company: MERCK; PARKE-DAVIS			Calc. LogP (KowWin): -0.31
Lines of Data: 4	Anti-HIV Enzyme data: 0	Lines of Data: 142	TB Min MIC 0.3 ug/mL	TB Min IC50 < 0.5 ug/mL	Links to NIST by AIDS#
Number of References: 3	Number of References: 0	Number of References: 40	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; DNA GYRASE INHIBITORS; NORFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid			Synonyms Ciprofloxacin Cipro (Hydrochloride) Bay q 3939 Bay o 9867 (Hydrochloride) Ciproxan Ciloxan (Hydrochloride) Ciprofloxacine CPFX NSC620634 (HYDROCHLORIDE)		AIDS# 001992
					Links to ChemID Plus by CAS# 86393-32-0 [HYDROCHLORIDE, MONOHYDRATE] 85721-33-1
					Links to PubChem by AIDS# 001992
HYDROCHLORIDE SALT, MONOHYDRATE; OR HYDROCHLORIDE SALT
C17 H18 F N3 O3		MW: 331.35			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 7	PHIA (Flexible Bonds): 3.8	Calc. LogP (MDL QSAR): -0.57
Company: BAYER; ALCON			Calc. LogP (KowWin): 0
Lines of Data: 11	Lines of Data: 2	Lines of Data: 1052	TB Min MIC 0.01 ug/mL	TB Min IC50 0.073 ug/mL	Links to NIST by AIDS#
Number of References: 5	Number of References: 2	Number of References: 151	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; DNA GYRASE INHIBITORS; NORFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid			Synonyms Enoxacin AT-2266 CI-919 PD 107779 NSC629661		AIDS# 002306
					Links to ChemID Plus by CAS# 74011-58-8
					Links to PubChem by AIDS# 002306

C15 H17 F N4 O3		MW: 320.32			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 8	PHIA (Flexible Bonds): 4.31	Calc. LogP (MDL QSAR): -0.99
Company: RHONE-POULENC RORER; PARKE-DAVIS			Calc. LogP (KowWin): -0.21
Lines of Data: 6	Anti-HIV Enzyme data: 0	Lines of Data: 55	TB Min MIC 0.3 ug/mL	TB Min IC50	Links to NIST by AIDS#
Number of References: 3	Number of References: 0	Number of References: 15	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; FLUOROQUINOLONES; ANTIBACTERIALS; ANTIMYCOBACTERIALS

Chemical Name: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3S)-			Synonyms S-(-)-Ofloxacin DR-3355: L-isomer of ofloxacin Levofloxacin RWJ-25213 Cravit L-Ofloxacin LVX		AIDS# 002307
					Links to ChemID Plus by CAS# 100986-85-4138199-71-0 [HEMIHYDRATE]
					Links to PubChem by AIDS# 002307
S-(-)-ISOMER; HEMIHYDRATE; OR HYDRATE
C18 H20 F N3 O4		MW: 361.37			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 8	PHIA (Flexible Bonds): 4.25	Calc. LogP (MDL QSAR): 0.11
Company: DAIICHI PHARM; ORTHO-MCNEIL			Calc. LogP (KowWin): -0.2
Lines of Data: 8	Anti-HIV Enzyme data: 0	Lines of Data: 501	TB Min MIC 0.12 ug/mL	TB Min IC50 < 1 ug/mL	Links to NIST by AIDS#
Number of References: 3	Number of References: 0	Number of References: 70	Lipinski: 4 (Score, out of 4)
Classes: ANTITUBERCULOUS AGENTS; PYRIDOBENZOXAZINES; OFLOXACINS; ANTIBACTERIALS; ANTIMYCOBACTERIALS

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