Opportunistic Infections  Citation List: 

September 16, 2009 – September 29, 2009

OPPORTUNISTIC PROTOZOA COMPOUNDS (including pneumocystis, cryptosporidium, toxoplasma, microsporidia [encephalitozoon, enterocytozoon, vittaforma])

1. Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model.

Dunay IR, Chan WC, Haynes RK, Sibley LD.

Antimicrob Agents Chemother. 2009 Oct;53(10):4450-6. Epub 2009 Jul 27.

PMID: 19635951 [PubMed - in process]

2. Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.

Huang TL, Vanden Eynde JJ, Mayence A, Collins MS, Cushion MT, Rattendi D, Londono I, Mazumder L, Bacchi CJ, Yarlett N.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5884-6. Epub 2009 Aug 23.

PMID: 19736009 [PubMed - in process]

ANTIFUNGAL COMPOUNDS ( includes Cryptococcus, Aspergillus, Candida, & Histoplasma)

3. Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles.

Sharma D, Narasimhan B, Kumar P, Judge V, Narang R, De Clercq E, Balzarini J.

J Enzyme Inhib Med Chem. 2009 Oct;24(5):1161-8.

PMID: 19772489 [PubMed - in process]

4. Discovery of highly potent novel antifungal azoles by structure-based rational design.

Wang W, Sheng C, Che X, Ji H, Cao Y, Miao Z, Yao J, Zhang W.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5965-9. Epub 2009 Aug 3.

PMID: 19748782 [PubMed - in process]

ANTIBACTERIAL COMPOUNDS (includes Mycobacterium spp.,  Drug Resistant, MAC, MDR)

5. Activity of novel peptide Arminin against multiresistant human pathogens shows considerable potential of phylogenetically ancient organisms as drug source.

Augustin R, Anton-Erxleben F, Jungnickel S, Hemmrich G, Spudy B, Podschun R, Bosch TC.

Antimicrob Agents Chemother. 2009 Sep 21. [Epub ahead of print]

PMID: 19770277 [PubMed - as supplied by publisher].

6. Hearn, M.J., M.H. Cynamon, M.F. Chen, R. Coppins, J. Davis, H. Joo-On Kang, A. Noble, B. Tu-Sekine, M.S. Terrot, D. Trombino, M. Thai, E.R. Webster, and R. Wilson, Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid. Eur J Med Chem, 2009. 44(10): p. 4169-78; PMID[19524330] http://www.ncbi.nlm.nih.gov/pubmed/19524330?ordinalpos=300&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum.

7. Lin, G., D. Li, L.P. de Carvalho, H. Deng, H. Tao, G. Vogt, K. Wu, J. Schneider, T. Chidawanyika, J.D. Warren, H. Li, and C. Nathan, Inhibitors selective for mycobacterial versus human proteasomes. Nature, 2009. 461(7264): p. 621-6; PMID[19759536] http://www.ncbi.nlm.nih.gov/pubmed/19759536?ordinalpos=172&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum.

8. Maddry, J.A., S. Ananthan, R.C. Goldman, J.V. Hobrath, D.K. C, C. Maddox, L. Rasmussen, R.C. Reynolds, J.A. Secrist, 3rd, M.I. Sosa, E.L. White, and W. Zhang, Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb), 2009; PMID[19783214] http://www.ncbi.nlm.nih.gov/pubmed/19783214?ordinalpos=72&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum.

9. Molina-Salinas, G.M., J. Borquez, S. Said-Fernandez, L.A. Loyola, A. Yam-Puc, P. Becerril-Montes, F. Escalante-Erosa, and L.M. Pena-Rodriguez, Antituberculosis activity of alkylated mulinane diterpenoids. Fitoterapia, 2009; PMID[19781604] http://www.ncbi.nlm.nih.gov/pubmed/19781604?ordinalpos=83&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum.

10. Mori, S., K. Shibayama, J.I. Wachino, and Y. Arakawa, Purification and molecular characterization of a novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv. Protein Expr Purif, 2009; PMID[19778616] http://www.ncbi.nlm.nih.gov/pubmed/19778616?ordinalpos=102&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum.

11. Raparti, V., T. Chitre, K. Bothara, V. Kumar, S. Dangre, C. Khachane, S. Gore, and B. Deshmane, Novel 4-(morpholin-4-yl)-N'-(arylidene)benzohydrazides: synthesis, antimycobacterial activity and QSAR investigations. Eur J Med Chem, 2009. 44(10): p. 3954-60; PMID[19464085] http://www.ncbi.nlm.nih.gov/pubmed/19464085?ordinalpos=312&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum.

Citations from the ISI Web of  Knowledge Listings for  O.I.

12. Lu, SE., et al

Occidiofungin, a Unique Antifungal Glycopeptide Produced by a Strain of Burkholderia contaminans
BIOCHEMISTRY  2009 (Sept.) 48: 8312 – 8321