1. Toward the Back-Up of
Boceprevir (SCH 503034): Discovery of New Extended P(4)-Capped Ketoamide
Inhibitors of Hepatitis C Virus NS3 Serine Protease with Improved Potency and
Pharmacokinetic Profiles.
Bogen SL, Pan W, Ruan S, Nair LG, Arasappan A, Bennett F, Chen KX, Jao E,
Venkatraman S, Vibulbhan B, Liu R, Cheng KC, Guo Z, Tong X, Saksena AK,
Girijavallabhan V, Njoroge FG.
J Med Chem. 2009 May 20. [Epub ahead of print]
PMID: 19456105 [PubMed - as supplied by publisher]
2. Structure-based
discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus
helicase.
Chen CS, Chiou CT, Chen GS, Chen SC, Hu CY, Chi WK, Chu YD, Hwang LH, Chen PJ,
Chen DS, Liaw SH, Chern JW.
J Med Chem. 2009 May 14;52(9):2716-23.
PMID: 19419203 [PubMed - in process]
3. The design, synthesis,
and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine
against hepatitis C virus replication: the discovery of
4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
Smith DB, Kalayanov G, Sund C, Winqvist A, Maltseva T, Leveque VJ, Rajyaguru S,
Le Pogam S, Najera I, Benkestock K, Zhou XX, Kaiser AC, Maag H, Cammack N,
Martin JA, Swallow S, Johansson NG, Klumpp K, Smith M.
J Med Chem. 2009 May 14;52(9):2971-8.
PMID: 19341305 [PubMed - in process]