HBV Drugs in Development

Drug Class	Sponsor and/or Company	Drug Name	Alt Name	Drug Status	Notes	AIDS#
Antibody, Monoclonal	Green Cross Corporation	GC1102	Recombinant Hepatitis B Immunoglobulin	Phase 2	Completed
Antibody, Monoclonal	Vir Biotechnology	VIR-3434		Phase 2	Active, Not Recruiting
Antibody, Monoclonal (PDL1 Inhibitor)	Ascletis Pharmaceuticals	Envafolimab	ASC22; KN035	Phase 2	Completed
Apoptosis Inducer	Ascentage Pharma Group	APG-1387		Phase 2	Recruiting
Core Protein / Capsid Inhibitor	Janssen Sciences	JNJ 56136379	JNJ-6379	Phase 2	Completed
Core Protein / Capsid Inhibitor	Qilu Pharmaceuticals	QL-007		Phase 2	Unknown
Core Protein / Capsid Inhibitor	Hoffmann-La Roche	RO7049839		Phase 2	Completed
Core Protein / Capsid Inhibitor	Assembly Biosciences	Vebicorvir	ABI-H0731	Phase 2	Terminated
Core Protein / Capsid Inhibitor	Enanta Pharmaceuticals	EDP-514		Phase 1	Completed
Core Protein / Capsid Inhibitor	Aligos Therapeutics	ALG-000184		Phase 1	Unknown
Core Protein / Capsid Inhibitor	Assembly Biosciences	ABI-4334		Phase 1	Recruiting
Core Protein / Capsid Inhibitor	Arbutus Biopharma Corporation	AB-836		Phase 1	Terminated
Core Protein / Capsid Inhibitor	Assembly Biosciences	ABI-H3733		Phase 1	Completed
Core Protein / Capsid Inhibitor	Assembly Biosciences	ABI-H2158		Phase 2	Terminated
FXR Agonist	Enyo Pharma	EYP001a		Phase 2	Terminated
RNA Gene Silencer (Antisense Oligonucleotide)	Hoffmann-La Roche	RO7062931		Phase 1	Completed
RNA Gene Silencer (Antisense Oligonucleotide)	Ionis Pharmaceuticals and GlaxoSmithKline	Bepirovirsen	GSK3228836; IONIS-HBVRx	Phase 3	Active, Not Recruiting	626929
RNA Gene Silencer (RNAi / siRNA)	Aligos Therapeutics	ALG-125755		Phase 1	Terminated
RNA Gene Silencer (RNAi / siRNA)	Dicerna Pharmaceuticals	DCR HBVS		Phase 1	Completed
RNA Gene Silencer (RNAi / siRNA)	Hoffmann-La Roche	RO7445482	RG6346	Phase 2	Completed
RNA Gene Silencer (RNAi / siRNA)	Janssen Research & Development	JNJ-73763989	JNJ-3989	Phase 2	Completed
RNA Gene Silencer (RNAi / siRNA)	Vir Biotechnology	VIR-2218		Phase 2	Completed
TLR-8 Agonist	Gilead Sciences	Selgantolimod	GS9688	Phase 2	Completed
Viral Polymerase Inhibitor	GlaxoSmithKline	Tenofovir Disoproxil Fumarate	GSK548470	Phase 3	Completed	080741
Viral Polymerase Inhibitor	Antios Therapeutics	ATI-2173	Prodrug of Clevudine	Phase 2	Terminated
Viral Polymerase Inhibitor	Dong-A ST Co.	Tenofovir Disoproxil Orotate	DA-2802	Phase 3	Completed

Sources: ClinicalTrials.gov and sponsor websites.

Some useful sites where additional information on these drugs may be found:

If using ChemDB information for publication or abstract presentation, please cite the website in addition to the original information source. Database last updated: January 2025

Division of AIDS Anti-HIV/OI/TB Therapeutics Database

HBV Drugs in Development