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HBV Drugs in Development


Drug ClassSponsor and/or CompanyDrug NameAlt NameDrug StatusNotesAIDS#
Antibody, MonoclonalVir BiotechnologyVIR-3434 Phase 2Recruiting 
Antibody, MonoclonalGreen Cross CorporationGC1102Recombinant Hepatitis B ImmunoglobulinPhase 2Completed 
Antibody, Monoclonal (PDL1 Inhibitor)Ascletis PharmaceuticalsEnvafolimabASC22; KN035Phase 2Recruiting 
Apoptosis InducerAscentage Pharma GroupDasminapantAPG-1387Phase 2Recruiting 
Core Protein / Capsid InhibitorAligos TherapeuticsALG-000184Prodrug of Capsid Assembly Modulator, ALG-001075Phase 1Recruiting 
Core Protein / Capsid InhibitorJanssen SciencesBersacapavirJNJ 56136379; JNJ-6379Phase 2Completed 
Core Protein / Capsid InhibitorEnanta PharmaceuticalsEDP-514 Phase 1Completed 
Core Protein / Capsid InhibitorSunshine Lake Pharma Co., Ltd.MorphothiadinGLS4Phase 2Completed 620680
Core Protein / Capsid InhibitorAssembly BiosciencesABI-H3733 Phase 1Completed 
Core Protein / Capsid InhibitorAssembly BiosciencesABI-H2158 Phase 2Terminated 
Core Protein / Capsid InhibitorAssembly BiosciencesABI-4334 Phase 1Recruiting 
Core Protein / Capsid InhibitorArbutusAB-836 Phase 1Terminated 
Core Protein / Capsid InhibitorQilu PharmaceuticalsQL-007 Phase 2Unknown 
Core Protein / Capsid InhibitorVenatorxVNRX-9945 Phase 1Terminated 
Core Protein / Capsid InhibitorAssembly BiosciencesVebicorvirABI-H0731Phase 2Terminated 
Core Protein / Capsid InhibitorHoffman-La RocheRO7049389RG7907Phase 1Completed 
FXR AgonistEnyo PharmaEYP001a Phase 2Terminated 
RNA Gene Silencer (Antisense Oligonucleotide)Ionis Pharmaceuticals and GlaxoSmithKlineBepirovirsenGSK3228836; IONIS-HBVRxPhase 3Recruiting 
RNA Gene Silencer (Antisense Oligonucleotide)Hoffman-La RocheRO7062931 Phase 1Completed 
RNA Gene Silencer (RNAi / siRNA)Dicerna PharmaceuticalsDCR HBVS Phase 1Completed 
RNA Gene Silencer (RNAi / siRNA)Janssen Research & DevelopmentJNJ-73763989JNJ-3989Phase 2Completed 
RNA Gene Silencer (RNAi / siRNA)Vir BiotechnologyVIR-2218ALN HBV02Phase 2Completed 
TLR-8 AgonistGilead SciencesSelgantolimodGS9688Phase 2Completed 
Viral Polymerase InhibitorDong-A ST Co.Tenofovir Disoproxil OrotateDA-2802Phase 3Completed 
Viral Polymerase InhibitorAntios TherapeuticsATI-2173Prodrug of ClevudinePhase 2Terminated 
Viral Polymerase InhibitorGlaxoSmithKlineViread™GSK548470; Tenofovir Disoproxil FumarateFDA Approved August 2008  080741

Sources: ClinicalTrials.gov and sponsor websites.

If using ChemDB information for publication or abstract presentation, please cite the website in addition to the original information source.    Database last updated: September 2023