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TB Drugs in Development


Drug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Cell Wall Synthesis InhibitorAsubio PharmaFaropenemFarom; ALP 201; BLA 857Phase 2Recruiting 545326
Cell Wall Synthesis InhibitorAstraZeneca; Sanofi; Sumitomo Dainippon PharmaMerrem™ICI 194660; ICI 213689; MeropenemPhase 2Recruiting 007788
Cell Wall Synthesis InhibitorSequellaSQ-109 Phase 2Completed 207396
Cell Wall Synthesis InhibitorGlobal Alliance for TB Drug Development; NovartisTBA-354 Phase 1Terminated 510946
Cytochrome bc1 Complex InhibitorQurientQ-203 Phase 1Ongoing 
DNA Replication Inhibitor/TB Cell Division InhibitorBayer; Schering-Plough MoxifloxacinMXFX; BAY 12-8039Phase 3Recruiting 070017
DNA Replication Inhibitor/TB Cell Division InhibitorDaiichi Pharm; Sanofi-Aventis; Ortho-McneilLevofloxacinS-(-)-Ofloxacin; DR-3355; RWJ-25213; Cravit; L-Ofloxacin; LVX; Levaquin; TavanicPhase 3Recruiting 002307
DNA Replication Inhibitor/TB Cell Division InhibitorBayerFlagyl™Metronidazole; Bayer 5360; Methronidazole; MTZ; RP 8823; SC 10295; WagitranPhase 2Completed 007953
DNA Replication Inhibitor/TB Cell Division InhibitorParke-Davis; Kyorin Pharm; PfizerTequin™Gatifloxacin; GTFX; BMS-206584; AM-1155; CG 5501; PD-135432; GATPhase 1/2Completed 044913
Intracellular NO ReleasePathogenesis Corp; ChironPretomanidPA-824Phase 3Recruiting 007331
Mycolic Acid Biosynthesis InhibitorOtsuka PharmDelamanidOPC-67683Phase 3Ongoing 182259
Protein Synthesis Inhibitor/TB Growth InhibitorAstrazenecaAZD-5847 Phase 2aCompleted 554767
Protein Synthesis Inhibitor/TB Growth InhibitorPharmacia & Upjohn, Inc.; PfizerSutezolidPNU-100480; PF-02341272Phase 2aCompleted 045415
Protein Synthesis Inhibitor/TB Growth InhibitorPharmacia & Upjohn, Inc.; PfizerZyvox™Linezolid; PNU-100766Phase 3Recruiting 070944

Last Updated: April 2017