NIAID Banner Logo Image

TB Drugs in Development


Drug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Cell Wall Synthesis InhibitorUniversity Medical Center GroningenInvanzErtapenemPhase 2Completed 
Cell Wall Synthesis InhibitorAsubio PharmaFarom™FaropenemPhase 2Completed 545326
Cell Wall Synthesis InhibitorNearmedic Plus LLCMacozinoneMCZ; PBTZ-169Phase 1Completed 
Cell Wall Synthesis InhibitorJohns Hopkins University Merrem™Meropenem; SM-7338Phase 2Completed 007788
Cell Wall Synthesis InhibitorNearmedic Plus LLC; OCT LLCPBTZ169 Phase 1Completed 573761
Cell Wall Synthesis InhibitorGlobal Alliance for TB Drug DevelopmentTBA-7371 Phase 1Recruiting 555726
Cell Wall Synthesis InhibitorSequellaSQ-109 Phase 2Completed 207396
Cell wall synthesis inhibitorGlobal Alliance for TB Drug Development; NovartisTBA-354 Phase 1Completed 510946
Cytochrome bc1 Complex InhibitorQurientQ-203 Phase 1Completed 594207
DNA Replication Inhibitor/TB Cell division inhibitorDaiichi Pharm; Sanofi-Aventis; Ortho-McneilLevaquin™; Tavanic™S-(-)-Ofloxacin; DR-3355; RWJ-25213; Cravit; L-Ofloxacin; Levofloxacin; LVXPhase 3Ongoing 002307
DNA Replication Inhibitor/TB Cell division inhibitorBayer; Schering-Plough Avelox™Moxifloxacin; MXFX; BAY 12-8039; Actira; AveloxPhase 3Completed 070017
DNA Replication Inhibitor/TB Cell division inhibitorBayerFlagyl™Metronidazole; Bayer 5360; Clont; Danizol; Gineflavir; Metric 21; Trichazol; Trichopal; Trivazol; VagilenPhase 2Completed 007953
DNA Replication Inhibitor/TB Cell division inhibitorParke-Davis; Kyorin Pharm; PfizerTequin™Gatifloxacin; GTFX; BMS-206584; AM-1155; CG 5501; PD-135432; GATPhase 1/2Completed 044913
Intracellular NO ReleasePathogenesis Corp; ChironPretomanidPA-824Phase 3Ongoing 007331
Leucyl-tRNA Synthetase (LeuRS) InhibitorGlaxoSmithKlineGSK3036656GSK070Phase 1Completed 599488
Monoclonal AntibodyNational University, SingaporePascolizumabAnti-IL-4 AntibodyPhase 2Ongoing 
Mycolic acid biosynthesis inhibitorOtsuka PharmDeltyba™Delamanid; OPC-67683Phase 3Completed 182259
Protein Synthesis InhibitorMicuRx PharmaceuticalsMRX-4Prodrug of Contezolid (MRX-1)Phase 1Completed 
Protein Synthesis Inhibitor/TB growth InhibitorAstraZenecaAZD-5847AZD2563; PosizolidPhase 2Completed 554767
Protein Synthesis Inhibitor/TB growth InhibitorPharmacia & Upjohn, Inc.; PfizerSutezolidPNU-100480; PF-02341272; OxazolidininonePhase 2Completed 045415
Protein Synthesis Inhibitor/TB growth InhibitorLegoChem Biosciences, Inc.DelpazolidLCB01-0371Phase 2Recruiting 581214
Protein Synthesis Inhibitor/TB growth InhibitorsPharmacia & Upjohn, Inc.; PfizerZyvox™Linezolid; PNU-100766; LZDPhase 3Recruiting 070944
Pyruvate-ferredoxin oxidoreductase inhibitorWeill Medical College of Cornell UniversityAlinia™ ; Nizonide™NitazoxanidePhase 2Completed 057131
UnidentifiedScientific Center for Anti-infectious Drugs, KazakhstanFS-1 Phase 3Recruiting 

Database last updated: September 2018