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TB Drugs in Development


Drug ClassSponsor and/or CompanyDrug NameAlt NameDrug StatusNotesAIDS#
Antibody, MonoclonalNational University, SingaporePascolizumabAnti-IL-4 AntibodyPhase 2Unknown 
Cell Wall Synthesis InhibitorEuropean and Developing Countries Clinical Trials Partnership (EDCTP); Michael Hoelscher, Ludwig-Maximilians, University of MunichBTZ043Benzothiazinone derivativePhase 1/2Recruiting 538411
Cell Wall Synthesis InhibitorGlobal Alliance for TB Drug DevelopmentTBA-7371An azaindolePhase 2Suspended 555726
Cell Wall Synthesis InhibitorGlobal Alliance for TB Drug DevelopmentTBA-354A nitroimidazolePhase 1Terminated 510946
Cell Wall Synthesis InhibitorEuropean and Developing Countries Clinical Trials Partnership (EDCTP); SequellaSQ-109A novel 1,2-ethylene diaminePhase 2Completed 207396
Cell Wall Synthesis InhibitorOtsuka PharmOPC-1678323,4-dihydrocarbostyril derivativePhase 1/2Active, Not Recruiting 
Cell Wall Synthesis InhibitorJohns Hopkins University Merrem™Meropenem; SM-7338Phase 2Recruiting 007788
Cell Wall Synthesis InhibitorInnovative Medicines for Tuberculosis; Nearmedic Plus LLCMacozinoneMCZ; PBTZ-169Phase 1Completed 573761
Cell Wall Synthesis InhibitorUniversity Medical Center GroningenInvanz™Ertapenem; MK-0826Phase 2Completed 604819
Cell Wall Synthesis InhibitorNational University, Singapore; Asubio PharmaFarom™FaropenemPhase 2Completed 545326
CombinationUniversity Medical Center Groningen, NetherlandsIsoniazid and Co-Trimoxazole (Trimethoprim and Sulfamethoxazole) Phase 3Completed 
CombinationThe HIV Netherlands Australia Thailand Research Collaboration Indinavir and Ritonavir Phase 1/2Completed 
CombinationGlobal Alliance for TB Drug DevelopmentMidazolam and PA-824 Phase 1Completed 
CombinationPfizerLersivirine (UK-453,061) and Rifabutin Phase 1Completed 
CombinationNational University Hospital, SingaporeCelecoxib (Celebrex) & Rifampicin & Pyrazinamide Phase 1Completed 
CombinationGlobal Alliance for TB Drug DevelopmentBPaMZBedaquiline & Pretomanid & Moxifloxacin & PyrazinamidePhase 2/3Active, Not Recruiting 
CombinationNational University Hospital, SingaporeFaropenem & Amoxicillin (clavulanic acid) & Cefadroxil & Rifampicin Phase 2Completed 
CombinationNational Institute of Allergy and Infectious Diseases (NIAID)Imatinib & Isoniazid & Rifabutin Phase 2Not Yet Recruiting 
Cytochrome bc1 Complex InhibitorQurient Co., Ltd.TelacebecQ203Phase 2Completed 594207
DNA Methyltransferase InhibitorBaylor College of Medicine; Celgene CorporationVidaza™Azacitidine; AzacytidinePhase 2Not Yet Recruiting 000615
DNA Replication Inhibitor/TB Cell Division InhibitorGlobal Alliance for TB Drug Development; Bayer; Schering-PloughAvelox™Moxifloxacin; MXFX; BAY 12-8039; Actira; AveloxPhase 3Completed 070017
DNA Replication Inhibitor/TB Cell Division InhibitorIUATLD, Inc ; Daiichi Pharm; Sanofi-Aventis; Ortho-McneilLevaquin™; Tavanic™S-(-)-Ofloxacin; DR-3355; RWJ-25213; Cravit; L-Ofloxacin; Levofloxacin; LVXPhase 3Active, Not Recruiting 002307
DNA Replication Inhibitor/TB Cell Division InhibitorNational Institute of Allergy and Infectious Diseases (NIAID); BayerFlagyl™Metronidazole; Bayer 5360; Clont; Danizol; Gineflavir; Metric 21; Trichazol; Trichopal; Trivazol; VagilenPhase 2Completed 007953
DNA Replication Inhibitor/TB Cell Division InhibitorNational Institute of Allergy and Infectious Diseases (NIAID); Parke-Davis; Kyorin Pharm; PfizerTequin™Gatifloxacin; GTFX; BMS-206584; AM-1155; CG 5501; PD-135432; GATPhase 3Unknown 044913
GyrB ATPase InhibitorSpero Therapeutics, LLCSPR720VXc-100; VXc-486; An ethyl urea benzimidazolePhase 1Completed 
Host-directed TherapyJohns Hopkins University Pravachol™PravastatinPhase 2Recruiting 488445
Leucyl-tRNA Synthetase (LeuRS) InhibitorGlaxoSmithKlineGSK3036656GSK070; GSK656Phase 2Suspended 599488
Mycolic Acid Biosynthesis InhibitorWits Health Consortium (Pty) Ltd; Otsuka PharmDeltyba™Delamanid; OPC-67683Phase 3Active, Not Recruiting 182259
Protein Synthesis InhibitorMicuRx PharmaceuticalsMRX-4Prodrug of Contezolid (MRX-1)Phase 1Completed 
Protein Synthesis Inhibitor/TB Growth InhibitorNational Institute of Allergy and Infectious Diseases (NIAID); AstraZenecaAZD-5847AZD2563; PosizolidPhase 2Completed 554767
Protein Synthesis Inhibitor/TB Growth InhibitorEuropean and Developing Countries Clinical Trials Partnership (EDCTP); Pharmacia & Upjohn, Inc.; PfizerSutezolidPNU-100480; PF-02341272; OxazolidinonePhase 2Not Yet Recruiting 045415
Protein Synthesis Inhibitor/TB Growth InhibitorLegoChem Biosciences, Inc.DelpazolidLCB01-0371Phase 2Completed 581214
Protein Synthesis Inhibitor/TB Growth InhibitorGlobal Alliance for TB Drug DevelopmentTBI-223Novel oxazolidinonePhase 1Completed 592820
Protein Synthesis Inhibitor/TB Growth InhibitorGlobal Alliance for TB Drug Development; Pharmacia & Upjohn, Inc.; PfizerZyvox™Linezolid; LZD; PNU-100766Phase 3Active, Not Recruiting 070944
Protein Synthesis Inhibitor/TB Growth InhibitorNational University Hospital, Singapore Vibramycin™DoxycyclinePhase 2Completed 000242
Pyruvate-Ferredoxin Oxidoreductase InhibitorWeill Medical College of Cornell UniversityAlinia™; Nizonide™NitazoxanidePhase 2Completed 057131
UnidentifiedScientific Center for Anti-infectious Drugs, KazakhstanFS-1Molecular iodine complex with bioorganic ligands, magnesium and lithium halogenidesPhase 3Active, Not Recruiting 

Sources: ClinicalTrials.gov and sponsor websites.

If using ChemDB information for publication or abstract presentation, please cite the website in addition to the original information source.    Database last updated: September 2020