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1. 60020 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Novel human, feline, chicken and other animal interferons and their antiproliferative and antiviral uses

Pestka, Sidney and Krause, Christopher D

PATENT: WO 2006099451 ISSUE DATE: 20060921

APPLICATION: 2006 PP: 156pp.

ASSIGNEE: (University of Medicine & Dentistry of New Jersey, USA

2. 60021 DMID-LS-137; SCIFINDER-DMID-1/29/2007

4-Aminoquinoline compounds for treating virus-related conditions

Olivo, Paul D, Buscher, Benjamin A, Dyall, Julie, Jocket-Balsarotti, Jennifer I, O'Guin, Andrew K, Roth, Robert M, Zhou, Yi, Franklin, Gary W, and Starkey, Gale W

PATENT: WO 2006121767 ISSUE DATE: 20061116

APPLICATION: 2006 PP: 93pp.


3. 60022 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Small molecule inhibitors against West Nile virus replication

Gu, Baohua, Block, Tim, and Cuconati, Andy

PATENT: WO 2007005541 ISSUE DATE: 20070111

APPLICATION: 2006 PP: 81pp.

ASSIGNEE: (Philadelphia Health & Education Corporation, d b a Drexel University College of Medicine USA

4. 60023 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Preparation of 2,3,4,9-tetrahydro-1H-b-carbolines for treatment of dengue fever, yellow fever, West Nile virus, and hepatitis C virus infection

Gudmundsson, Kristjan

PATENT: WO 2007002051 ISSUE DATE: 20070104

APPLICATION: 2006 PP: 53pp.

ASSIGNEE: (Smithkline Beecham Corporation, USA

5. 60024 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Yellow Fever: A Disease that Has Yet to be Conquered

Barrett Alan D T and Higgs Stephen

Annu Rev Entomol 2007. 52: 209-29.

6. 60025 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Viral and cellular determinants involved in hepadnaviral entry

Glebe Dieter and Urban Stephan

World J Gastroenterol 2007. 13(1): 22-38.

7. 60026 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Inhibitors of Epstein-Barr virus nuclear antigen 1, screening methods, and therapeutic use

Kieff, Elliott and Kang, Myung-Soo

PATENT: WO 2007002587 ISSUE DATE: 20070104

APPLICATION: 2006 PP: 66pp.

ASSIGNEE: (The Brigham and Women's Hospital, Inc. USA

8. 60027 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Reactivation of Herpes Simplex Virus Type 1 and Varicella-Zoster Virus and Therapeutic Effects of Combination Therapy With Prednisolone and Valacyclovir in Patients With Bell's Palsy

Kawaguchi, Kazuhiro, Inamura, Hiroo, Abe, Yasuhiro, Koshu, Hidehiro, Takashita, Emi, Muraki, Yasushi, Matsuzaki, Yoko, Nishimura, Hidekazu, Ishikawa, Hitoshi, Fukao, Akira, Hongo, Seiji, and Aoyagi, Masaru

Laryngoscope 2007. 117(1): 147-156

9. 60028 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus

McCray, Paul B Jr, Pewe, Lecia, Wohlford-Lenane, Christine, Hickey, Melissa, Manzel, Lori, Shi, Lei, Netland, Jason, Jia, Hong Peng, Halabi, Carmen, Sigmund, Curt D, Meyerholz, David K, Kirby, Patricia, Look, Dwight C, and Perlman, Stanley

Journal of Virology 2007. 81(2): 813-821

10. 60029 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor

Tseng Chien-Te K, Huang Cheng, Newman Patrick, Wang Nan, Narayanan Krishna, Watts Douglas M, Makino Shinji, Packard Michelle M, Zaki Sherif R, Chan Teh-Sheng, and Peters Clarence J

J Virol 2007. 81(3): 1162-73.

11. 60030 DMID-LS-137; WOS-DMID-1/29/2007

Naturally-occurring hepatitis C virus protease variants: implications for resistance to new antivirals

Lopez-Labradorl, FX, Moya, A, and Gonzalez-Candelas, F

JOURNAL OF CLINICAL VIROLOGY: J. Clin. Virol 2006. 36: S35-1


12. 60031 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Low-toxicity and long-circulating analogs of human interferon-a modified with PEG for treating cancer and viral infection

Villarete, Lorelie H and Liu, Chih-Ping

PATENT: WO 2007002233 ISSUE DATE: 20070104

APPLICATION: 2006 PP: 72pp.

ASSIGNEE: (Pepgen Corporation, USA

13. 60032 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Methods of use of non-ATP competitive tyrosine kinase inhibitors to treat pathogenic infection

Kalman, Daniel and Bornmann, William Gerard

PATENT: WO 2007002441 ISSUE DATE: 20070104

APPLICATION: 2006 PP: 85pp.

ASSIGNEE: (Emory University, USA

14. 60033 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: From anti-pestivirus to anti-hepatitis C virus activity

Puerstinger, Gerhard, Paeshuyse, Jan, De Clercq, Erik, and Neyts, Johan

Bioorganic & Medicinal Chemistry Letters 2007. 17(2): 390-393

15. 60034 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Preparation of quinolones as antivirals

Kumar, Dange Vijay and Rai, Roopa

PATENT: WO 2007005779 ISSUE DATE: 20070111

APPLICATION: 2006 PP: 50pp.

ASSIGNEE: (Virobay, Inc. USA

16. 60035 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Preparation of prolyl peptides as HCV inhibitors

Graupe, Michael, Link, John O, and Venkataramani, Chandrasekar

PATENT: WO 2007005838 ISSUE DATE: 20070111

APPLICATION: 2006 PP: 87pp.

ASSIGNEE: (Virobay, Inc. USA

17. 60036 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Preparation of amino acid amides as non-nucleoside anti-hepacivirus agents

Boyd, Vincent A, Cameron, Dale R, Jia, Qi, Sgarbi, Paulo WM, and Wacowich-Sgarbi, Shirley A

PATENT: WO 2007002639 ISSUE DATE: 20070104

APPLICATION: 2006 PP: 303pp.

ASSIGNEE: (Migenix Inc., Can.

18. 60037 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Preparation of pyrazolopyridinecarboxamides as inhibitors of beta-adrenergic receptor kinase 1

Steinhagen, Henning, Huber, Jochen, Ritter, Kurt, Pirard, Bernard, Bjergarde, Kirsten, Patek, Marcel, Smrcina, Martin, and Wei, Linli

PATENT: WO 2007000241 ISSUE DATE: 20070104

APPLICATION: 2006 PP: 71pp.

ASSIGNEE: (Sanofi-Aventis Deutschland G.m.b.H., Germany

19. 60038 DMID-LS-137; SCIFINDER-DMID-1/29/2007

Manufacture of anti-HCV drugs with Fusarium

Aoki, Masahiro, Nagahashi, Yoshie, Kato, Hideyuki, Ito, Tatsuya, Masubuchi, Miyako, and Okuda, Toru

PATENT: WO 2007000994 ISSUE DATE: 20070104

APPLICATION: 2006 PP: 81pp.

ASSIGNEE: (Chugai Seiyaku Kabushiki Kaisha, Japan

20. 60039 DMID-LS-137; SCIFINDER-DMID-1/29/2007

In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporin

El-Farrash Mohamed A, Aly Hussein H, Watashi Koichi, Hijikata Makoto, Egawa Hiroto, and Shimotohno Kunitada

Microbiol Immunol 2007. 51(1): 127-33.

21. 60040 DMID-LS-137; WOS-DMID-1/29/2007

The role of peginterferon alpha-2a (40kD) plus ribavirin in the management of chronic hepatitis C mono-infection

Simpson, D and Curran, MP

DISEASE MANAGEMENT & HEALTH OUTCOMES: Dis. Manag. Health Outcomes 2006. 14(5): 303-320, 18


22. 60041 DMID-LS-137; SCIFINDER-DMID-1/29/2007

A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication

Kim Sun Suk, Peng Lee F, Lin Wenyu, Choe Won-Hyeok, Sakamoto Naoya, Schreiber Stuart L, and Chung Raymond T

Gastroenterology 2007. 132(1): 311-20.

23. 60042 DMID-LS-137; WOS-DMID-1/29/2007

HBV drug resistance

Locarnini, S

ANTIVIRAL THERAPY: Antivir. Ther 2006. 11(5): P4-1


24. 60043 DMID-LS-137; WOS-DMID-1/29/2007

Tenofovir disoproxil fumarate (TDF) and adefovir dipivoxil (ADV) are effective in chronic hepatitis B virus (HBV) infection in subjects who are co-infected with HIV: HBV and HIV drug resistance results of ACTG Protocol A5127

Johnson, VA, Hazelwood, JD, Andersen, J, Miller, AB, Liu, T, Alston-Smith, B, Brosgart, CL, Rooney, JF, Polsky, B, and Peters, MG

ANTIVIRAL THERAPY: Antivir. Ther 2006. 11(5): S11-1


25. 60044 DMID-LS-137; WOS-DMID-1/29/2007

Ribavirin treatment, but not interferon pharmacokinetics, is associated with suppression of viral rebounds during high dose interferon-alpha-2a therapy of hepatitis C infection

Frost, SDW, Ruffini, L, Richman, DD, and Lake-Bakaar, G

ANTIVIRAL THERAPY: Antivir. Ther 2006. 11(5): S13-1


26. 60045 DMID-LS-137; WOS-DMID-1/29/2007

Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

Kobasa, D, Jones, SM, Shinya, K, Kash, JC, Copps, J, Ebihara, H, Hatta, Y, Kim, JH, Halfmann, P, Hatta, M, Feldmann, F, Alimonti, JB, Fernando, L, Li, Y, Katze, MG, Feldmann, H, and Kawaoka, Y

NATURE: Nature 2007. 445(7125): 319-323, 5


27. 60046 DMID-LS-137; WOS-DMID-1/29/2007

Docking and binding mode analysis of aryl diketoacids (ADK) at the active site of HCV RNA-dependent RNA polymerase

Kim, J and Chong, Y

MOLECULAR SIMULATION: Mol. Simul 2006. 32(14): 1131-1138, 8


28. 60047 DMID-LS-137; WOS-DMID-1/29/2007

Cytokine-activated natural killer cells exert direct killing of hepatoma cells harboring hepatitis C virus replicons

Larkin, J, Bost, A, Glass, JI, and Tan, SL

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH: J. Interferon Cytokine Res 2006. 26(12): 854-865, 12


29. 60048 DMID-LS-137; WOS-DMID-1/29/2007

Prediction of binding for a kind of non-peptic HCVNS3 serine protease inhibitors from plants by molecular docking and MM-PBSA method

Li, XD, Zhang, W, Qiao, XB, and Xu, XJ

BIOORGANIC & MEDICINAL CHEMISTRY: Bioorg. Med. Chem 2007. 15(1): 220-226, 7


30. 60049 DMID-LS-137; WOS-DMID-1/29/2007

Antiviral activity of proteasome inhibitors in herpes simplex virus-1 infection: role of nuclear factor-kappa B

La Frazia, S, Amici, C, and Sontoro, MG

ANTIVIRAL THERAPY: Antivir. Ther 2006. 11(8): 995-1004, 10


31. 60050 DMID-LS-137; WOS-DMID-1/29/2007

Hepatitis C virus (HCV) NS5B nonnucleoside inhibitors specifically block single-stranded viral RNA synthesis catalyzed by HCV replication complexes in vitro

Yang, WG, Sun, YN, Phadke, A, Deshpande, M, and Huang, MJ

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY: Antimicrob. Agents Chemother 2007. 51( 1): 338-342, 5


32. 60051 DMID-LS-137; WOS-DMID-1/29/2007

Hydantoin derivatives of L- and D-amino acids: Synthesis and evaluation of their antiviral and antitumoral activity

Rajic, Z, Zorc, B, Raic-Malic, S, Ester, K, Kralj, M, Pavelic, K, Balzarini, J, De Clercq, E, and Mintas, M

MOLECULES: Molecules 2006. 11(11): 12


33. 60052 DMID-LS-137; WOS-DMID-1/29/2007

N-1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors

Hernandez, AI, Familiar, O, Negri, A, Rodriguez-Barrios, F, Gago, F, Karlsson, A, Camarasa, MJ, Balzarini, J, and Perez-Perez, MJ

JOURNAL OF MEDICINAL CHEMISTRY: J. Med. Chem 2006. 49(26): 7766-7773, 8


34. 60053 DMID-LS-137; WOS-DMID-1/29/2007

Resveratrol inhibition of varicella-zoster virus replication in vitro

Docherty, JJ, Sweet, TJ, Bailey, E, Faith, SA, and Booth, T

ANTIVIRAL RESEARCH: Antiviral Res 2006. 72(3): 171-177, 7


35. 60054 DMID-LS-137; WOS-DMID-1/29/2007

Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats

Chang, YW, Yeh, TK, Lin, KT, Chen, WC, Yao, HT, Lan, SJ, Wu, YS, Hsieh, HP, Chen, CM, and Chen, CT

JOURNAL OF FOOD AND DRUG ANALYSIS: J. Food Drug Anal 2006. 14(4): 329-333, 5


36. 60055 DMID-LS-137; WOS-DMID-1/29/2007

Indomethacin has a potent antiviral activity against SARS coronavirus

Amici, C, Di Caro, A, Ciucci, A, Chioppa, L, Castilletti, C, Martella, V, Decaro, N, Buonavoglia, C, Capobianchi, MR, and Santoro, MG

ANTIVIRAL THERAPY: Antivir. Ther 2006. 11(8): 1021-1030, 10


37. 60056 DMID-LS-137; WOS-DMID-1/29/2007

Inhibitory effect of gamma interferon on BK virus gene expression and replication

Abend, JR, Low, JA, and Imperiale, MJ

JOURNAL OF VIROLOGY: J. Virol 2007. 81(1): 272-279, 8


38. 60057 DMID-LS-137; PUBMED-DMID-1/29/2007

In vitro activity evaluation of Parkia pendula seed lectin against human cytomegalovirus and herpes virus 6

Favacho, AR, Cintra, EA, Coelho, LC, and Linhares, MI

Biologicals 2007.


39. 60058 DMID-LS-137; PUBMED-DMID-1/29/2007

Antiviral Resistance and the Control of Pandemic Influenza

Lipsitch, M, Cohen, T, Murray, M, and Levin, BR

PLoS Med 2007. 4(1): e15


40. 60059 DMID-LS-137; PUBMED-DMID-1/29/2007

Bicyclol for chronic hepatitis C

Yang, X, Zhuo, Q, Wu, T, and Liu, G

Cochrane Database Syst Rev 2007.(1): CD004994


41. 60060 DMID-LS-137; PUBMED-DMID-1/29/2007

Neuraminidase inhibitors for preventing and treating influenza in children

Matheson, Nj, Harnden, A, Perera, R, Sheikh, A, and Symmonds-Abrahams, M

Cochrane Database Syst Rev 2007.(1): CD002744


42. 60061 DMID-LS-137; PUBMED-DMID-1/29/2007

Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against single-stranded positive-sense RNA genome viruses

Carta, A, Loriga, M, Paglietti, G, Ferrone, M, Fermeglia, M, Pricl, S, Sanna, T, Ibba, C, La, Colla P, and Loddo, R

Bioorg Med Chem 2007.


43. 60062 DMID-LS-137; PUBMED-DMID-1/29/2007

Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs

Schang, LM, St, Vincent MR, and Lacasse, JJ

Antivir Chem Chemother 2006. 17(6): 293-320


44. 60063 DMID-LS-137; PUBMED-DMID-1/29/2007

Inhibition of hepatitis B virus replication by shRNAs in stably HBV expressed HEPG2 2.2.15 cell lines

Kayhan, H, Karatayli, E, Turkyilmaz, AR, Sahin, F, Yurdaydin, C, and Bozdayi, AM

Arch Virol 2007.


45. 60064 DMID-LS-137; PUBMED-DMID-1/29/2007

West Nile virus

Kramer, LD, Li, J, and Shi, PY

Lancet Neurol 2007. 6(2): 171-81


46. 60065 DMID-LS-137; PUBMED-DMID-1/29/2007

Antiviral activity of berberine and related compounds against human cytomegalovirus

Hayashi, K, Minoda, K, Nagaoka, Y, Hayashi, T, and Uesato, S

Bioorg Med Chem Lett 2007.


47. 60066 DMID-LS-137; PUBMED-DMID-1/29/2007

Pegylation of IFN-alpha and antiviral activity

Boulestin, A, Kamar, N, Sandres-Saune, K, Alric, L, Vinel, JP, Rostaing, L, and Izopet, J

J Interferon Cytokine Res 2006. 26(12): 849-53


48. 60067 DMID-LS-137; PUBMED-DMID-1/29/2007

From actually toxic to highly specific--novel drugs against poxviruses

Sliva, K and Schnierle, B

Virol J 2007. 4: 8


49. 60068 DMID-LS-137; PUBMED-DMID-1/29/2007

N-Long-chain Monoacylated Derivatives of 2,6-Diaminopyridine with Antiviral Activity

Mibu, N, Yokomizo, K, Kashige, N, Miake, F, Miyata, T, Uyeda, M, and Sumoto, K

Chem Pharm Bull (Tokyo) 2007. 55(1): 111-4


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