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1. 60478 DMID-LS-141; WOS-DMID-3/26/2007

The Histone Deacetylase Inhibitor Fk228 Given Prior to Adenovirus Infection Can Boost Infection in Melanoma Xenograft Model Systems

Goldsmith, M. et al.

Molecular Cancer Therapeutics 2007. 6(2): 496-505


2. 60479 DMID-LS-141; PUBMED-DMID-3/26/2007

Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors

Chapel, C, Garcia, C, Bartosch, B, Roingeard, P, Zitzmann, N, Cosset, FL, Dubuisson, J, Dwek, RA, Trepo, C, Zoulim, F, and Durantel, D

J Gen Virol 2007. 88(Pt 4): 1133-43


3. 60480 DMID-LS-141; WOS-DMID-3/26/2007

Chlorpromazine and Apigenin Reduce Adenovirus Replication and Decrease Replication Associated Toxicity

Kanerva, A. et al.

Journal of Gene Medicine 2007. 9(1): 3-9


4. 60481 DMID-LS-141; PUBMED-DMID-3/26/2007

Relationship between HBV genotypes and anti-viral therapeutic efficacy of interferon-alpha

Ma, JC, Wang, LW, Li, XJ, Liao, YF, Hu, XY, and Gong, ZJ

Hepatobiliary Pancreat Dis Int 2007. 6(2): 166-71


5. 60482 DMID-LS-141; PUBMED-DMID-3/26/2007

In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus (HBV) mutants

Brunelle, MN, Lucifora, J, Neyts, J, Villet, S, Holy, A, Trepo, C, and Zoulim, F

Antimicrob Agents Chemother 2007.


6. 60483 DMID-LS-141; PUBMED-DMID-3/26/2007

Evolution of Resistant Mutant M414T in HCV Replicon Cells Treated with Polymerase Inhibitor A-782759

Lu, L, Mo, H, Pilot-Matias, TJ, and Molla, A

Antimicrob Agents Chemother 2007.


7. 60484 DMID-LS-141; WOS-DMID-3/26/2007

Discovery of Novel Antiviral Leads for the Treatment of Hantavirus Infections

Chung, D. et al.

American Journal of Tropical Medicine and Hygiene 2006 . 75(5): 277


8. 60485 DMID-LS-141; PUBMED-DMID-3/26/2007

Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure-Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase

Hollick, JJ, Rigoreau, LJ, Cano-Soumillac, C, Cockcroft, X, Curtin, NJ, Frigerio, M, Golding, BT, Guiard, S, Hardcastle, IR, Hickson, I, Hummersone, MG, Menear, KA, Martin, NM, Matthews, I, Newell, DR, Ord, R, Richardson, CJ, Smith, GC, and Griffin, RJ

J Med Chem 2007.


9. 60486 DMID-LS-141; PUBMED-DMID-3/26/2007

Production and characterization of monoclonal antibodies against different epitopes of Ebola virus antigens

Shahhosseini, S, Das, D, Qiu, X, Feldmann, H, Jones, SM, and Suresh, MR

J Virol Methods 2007.


10. 60487 DMID-LS-141; PUBMED-DMID-3/26/2007

Imidazo[1,2-a]pyridines with potent activity against herpesviruses

Gudmundsson, KS and Johns, BA

Bioorg Med Chem Lett 2007.


11. 60488 DMID-LS-141; SCIFINDER-DMID-3/26/2007


Chupakhin, ON, Rusinov, VL, Ulomskii, EN, Charushin, VN, Petrov, AYu, and Kiselev, OI

PATENT: RU 2294936 ISSUE DATE: 20070310

APPLICATION: 2005-54714 PP: 12pp.

ASSIGNEE: (Gos. Obraz. Uchrezhd. Vyssh. Prof. Obraz. Ural'skii Gos. Tekhn. Univ. -UPI, Russia and OOO Nauchno-Tekhn. Predpriyatie \"Ligand\")

12. 60489 DMID-LS-141; PUBMED-DMID-3/26/2007

Application of the Phosphoramidate ProTide Approach to 4'-Azidouridine Confers Sub-micromolar Potency versus Hepatitis C Virus on an Inactive Nucleoside

Perrone, P, Luoni, GM, Kelleher, MR, Daverio, F, Angell, A, Mulready, S, Congiatu, C, Rajyaguru, S, Martin, JA, Leveque, V, Pogam, SL, Najera, I, Klumpp, K, Smith, DB, and McGuigan, C

J Med Chem 2007.


13. 60490 DMID-LS-141; PUBMED-DMID-3/26/2007

Synthesis of novel 2'-methyl carbovir analogues as potent antiviral agents

Hong, JH

Arch Pharm Res 2007. 30(2): 131-137


14. 60491 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Synthesis and evaluation of a group of selective inhibitors of Ebola cell entry

Yermolina, Maria V, Wang, Jizhen, Wardrop, Duncan J, and Wang, Lijun

Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 2007.: MEDI-062

15. 60492 DMID-LS-141; PUBMED-DMID-3/26/2007

In vitro antiviral activity of Chamaecrista nictitans (Fabaceae) against herpes simplex virus: biological characterization of mechanisms of action

Herrero, Uribe L, Chaves, Olarte E, and Tamayo, Castillo G

Rev Biol Trop 2004. 52(3): 807-16


16. 60493 DMID-LS-141; PUBMED-DMID-3/26/2007

Antiviral triterpenoids from the medicinal plant Schefflera heptaphylla

Li, Y, Jiang, R, Ooi, LS, But, PP, and Ooi, VE

Phytother Res 2007.


17. 60494 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of seven-membered sugar ring nucleoside analogs as antiviral prodrug agents

Storer, Richard, Gosselin, Gilles, Dukhan, David, Leroy, Frederic, Meillon, Jean-Christophe, and Converd, Thierry

PATENT: WO 2007025043 ISSUE DATE: 20070301

APPLICATION: 2006 PP: 195pp.

ASSIGNEE: (Idenix Pharmaceuticals, Inc. USA and Centre National de la Recherche Scientifique)

18. 60495 DMID-LS-141; WOS-DMID-3/26/2007

Ribavirin, Human Convalescent Plasma and Anti-Beta(3) Integrin Antibody Inhibit Infection by Sin Nombre Virus in the Deer Mouse Model

Medina, R. et al.

Journal of General Virology 2007. 88: 493-505


19. 60496 DMID-LS-141; PUBMED-DMID-3/26/2007

Superior efficacy of helicase-primase inhibitor BAY 57-1293 for herpes infection and latency in the guinea pig model of human genital herpes disease

Baumeister, J, Fischer, R, Eckenberg, P, Henninger, K, Ruebsamen-Waigmann, H, and Kleymann, G

Antivir Chem Chemother 2007. 18(1): 35-48


20. 60497 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Human antibodies and immunoconjugates capable of neutralizing West Nile virus and other flaviviruses, and uses in diagnosis, prophylaxis and therapy

Throsby, Mark and De Kruif, Cornelis Adriaan

PATENT: US 2007042359 ISSUE DATE: 20070222

APPLICATION: 51 PP: 43pp., Cont.-in-part of Appl. No. PCT/EP05-052160.

ASSIGNEE: (Crucell Holland B.V., Neth.

21. 60498 DMID-LS-141; PUBMED-DMID-3/26/2007

High frequency of spontaneous helicase-primase inhibitor (BAY 57-1293) drug-resistant variants in certain laboratory isolates of HSV-1

Biswas, S, Swift, M, and Field, HJ

Antivir Chem Chemother 2007. 18(1): 13-23


22. 60499 DMID-LS-141; PUBMED-DMID-3/26/2007

Antiviral activity of human beta-defensin 3 against vaccinia virus

Howell, MD, Streib, JE, and Leung, DY

J Allergy Clin Immunol 2007.


23. 60500 DMID-LS-141; PUBMED-DMID-3/26/2007

Influenza neuraminidase antibodies provide partial protection for chickens against high pathogenic avian influenza infection

Sylte, MJ, Hubby, B, and Suarez, DL

Vaccine 2007.


24. 60501 DMID-LS-141; PUBMED-DMID-3/26/2007

Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation

Shepherd, J, Jones, J, Hartwell, D, Davidson, P, Price, A, and Waugh, N

Health Technol Assess 2007. 11(11): 1-224


25. 60502 DMID-LS-141; PUBMED-DMID-3/26/2007

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models

Burrer, R, Neuman, BW, Ting, JP, Stein, DA, Moulton, HM, Iversen, PL, Kuhn, P, and Buchmeier, MJ

J Virol 2007.


26. 60503 DMID-LS-141; PUBMED-DMID-3/26/2007

Updates on antiviral therapy for chronic hepatitis C

Toniutto, P, Fabris, C, Bitetto, D, Fornasiere, E, Rapetti, R, and Pirisi, M

Discov Med 2007. 7(37): 27-32


27. 60504 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Synthesis and antiviral activity of Sulforamate derivatives

Moriarty, Robert M, Naithani, Rajesh, Surve, Bhushan C, Tiwari, Vaibhav, and Shukla, Deepak

Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 2007.: MEDI-064

28. 60505 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Synthesis and antiviral activity of Abyssinone II analogs

Moriarty, Robert M, Surve, Bhushan C, Naithani, Rajesh, Chandersekera, Susantha N, Tiwari, Vaibhav, and Shukla, Deepak

Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 2007.: MEDI-063

29. 60506 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Optimizing the synthesis of N-methanocarbathymidine, a potent and selective antiviral agent

Marquez, Victor E and Ludek, Olaf R

Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 2007.: MEDI-061

30. 60507 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Protonated antimicrobial and antiviral compounds and methods for their use

Dale, Roderic MK

PATENT: US 2007053971 ISSUE DATE: 20070308

APPLICATION: 2006-28663 PP: 42pp., Cont.-in-part of U.S. Ser. No. 937,094.

ASSIGNEE: (Oligos Etc., Inc USA

31. 60508 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Antiviral compositions containing p-hydroxybenzoic acid and analogues for prevention and treatment of skin virus infections

Zhang, Qingmin and Qin, Weihua

PATENT: WO 2007014514 ISSUE DATE: 20070208

APPLICATION: 2006 PP: 18pp.

ASSIGNEE: (Shenghua Guangzhou Pharmaceutical Science & Technology Co., Ltd. Peop. Rep. China

32. 60509 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Use of acyl thiouracil derivatives as antiviral drug

Zhou, Pei, Feng, Meiqing, Sun, Chuanwen, Huang, Hai, and Zhou, Wei

PATENT: CN 1903203 ISSUE DATE: 20070131

APPLICATION: 1002-8153 PP: 11pp.

ASSIGNEE: (Fudan University, Peop. Rep. China

33. 60510 DMID-LS-141; PUBMED-DMID-3/26/2007

The effects of DNA methylation and histone deacetylase inhibitors on human papillomavirus early gene expression in cervical cancer, an in vitro and clinical study

de la Cruz-Hernandez, E, Perez-Cardenas, E, Contreras-Paredes, A, Cantu, D, Mohar, A, Lizano, M, and Duenas-Gonzalez, A

Virol J 2007 . 4: 18


34. 60511 DMID-LS-141; WOS-DMID-3/26/2007

Pf-03491390, (Formerly Idn-6556) a Pancaspase Inhibitor, Is Well-Tolerated and Effectively Reduces Raised Aminotransferases (Alt and Ast) in Chronic Active Hepatitis C (Hcv) Patients (Pts)

Shiffman, M. et al.

Hepatology 2006. 44(4): 224A


35. 60512 DMID-LS-141; WOS-DMID-3/26/2007

Inhibition of Hepatitis C Viral (Hcv) Replication by in-Vivo Dimerization of Stat1

Li, X. et al.

Hepatology 2006. 44(4): 307A-308A


36. 60513 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Antisense antiviral compound and method for treating picornavirus infection

Stein, David A, Bestwick, Richard K, Iversen, Patrick L, and Weller, Dwight D

PATENT: WO 2007030691 ISSUE DATE: 20070315

APPLICATION: 2006 PP: 51pp.

ASSIGNEE: (Avi Biopharma, Inc. USA

37. 60514 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of pyridazine derivatives as picornavirus inhibitors

Li, Song, Mi, Chunlai, Zheng, Zhibing, Zhao, Guoming, Zhou, Xinbo, and Gong, Zehui

PATENT: CN 1887875 ISSUE DATE: 20070103

APPLICATION: 1008-1813 PP: 38pp.

ASSIGNEE: (Institute of Pharmacology & Toxicology, Academy of Military Medical Sciences Peop. Rep. China

38. 60515 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Tetrahydrocarbazoles as potential therapeutic agents for human papillomavirus infection

Sebahar, Paul R, Brown, Kevin W, Gudmundsson, Kristjan S, Harvey, Robert, Richardson, Leah, and Sethna, Phiroze

Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 2007.: MEDI-087

39. 60516 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Methods for engineering artificial zinc finger proteins for inhibiting DNA replication of human papillomavirus

Sera, Takashi

PATENT: WO 2007024029 ISSUE DATE: 20070301

APPLICATION: 2006 PP: 53pp.

ASSIGNEE: (Kyoto University, Japan

40. 60517 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Antiviral compositions containing hydroxybenzoic acid ester and analogues for prevention and treatment of virus infections

Zhang, Qingmin and Qin, Weihua

PATENT: WO 2007014515 ISSUE DATE: 20070208

APPLICATION: 2006 PP: 23pp.

ASSIGNEE: (Shenghua (Guangzhou) Pharmaceutical Science & Technology Co., Ltd. Peop. Rep. China

41. 60518 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Docking and 3-D-QSAR analysis of HCV NS5B RNA-dependent RNA polymerase inhibitors based on a common benzothiadiazine scaffold

Odde, Srinivas, Sivaprakasam, Prasanna, and Doerksen, Robert J

Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 2007.: MEDI-085

42. 60519 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Tetracyclic indole derivatives as antiviral agents

Narjes, Frank and Stansfield, Ian

PATENT: WO 2007029029 ISSUE DATE: 20070315

APPLICATION: 2006 PP: 29pp.

ASSIGNEE: (Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A., Italy

43. 60520 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Quinazoline derivatives as antiviral agents

Donghi, Monica, Ferrara, Marco, Koch, Uwe, Narjes, Frank, Ontoria Ontoria, Jesus Maria, and Summa, Vincenzo

PATENT: WO 2007028789 ISSUE DATE: 20070315

APPLICATION: 2006 PP: 56pp.

ASSIGNEE: (Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A., Italy

44. 60521 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of 3',5'-cyclic nucleoside analogs as antiviral agents for treatment of HCV

Gunic, Esmir, Hong, Zhi, and Girardet, Jean-Luc

PATENT: WO 2007027248 ISSUE DATE: 20070308

APPLICATION: 2006 PP: 158pp.

ASSIGNEE: (Valeant Research & Development, USA

45. 60522 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors

Oertqvist, Pernilla, Peterson, Shane D, Aakerblom, Eva, Gossas, Thomas, Sabnis, Yogesh A, Fransson, Rebecca, Lindeberg, Gunnar, Danielson, UHelena, Karlen, Anders, and Sandstroem, Anja

Bioorganic & Medicinal Chemistry 2007. 15(3): 1448-1474

46. 60523 DMID-LS-141; WOS-DMID-3/26/2007

Role of Combination Antiviral Therapy in Pandemic Influenza

Tsiodras, S., Mooney, J., and Hatzakilis, A.

British Medical Journal 2007. 334(7588): 293-294


47. 60524 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of spiroisoxazoline-based peptidomimetics as inhibitors of serine proteases, particularly HCV NS3-NS4A protease

Cottrell, Kevin M, Maxwell, John, Tang, Qing, Grillot, Anne-Laure, Le Tiran, Arnaud, and Perola, Emanuele

PATENT: WO 2007025307 ISSUE DATE: 20070301

APPLICATION: 2006 PP: 489pp.

ASSIGNEE: (Vertex Pharmaceuticals Incorporated, USA

48. 60525 DMID-LS-141; WOS-DMID-3/26/2007

Platinum(Ii) and Palladium(Ii) Complexes of Pyridine-2-Carbaldehyde Thiosemicarbazone as Alternative Antiherpes Simplex Virus Agents

Kovala-Demertzi, D. et al.

Bioinorganic Chemistry and Applications 2007.


49. 60526 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of amino acid-containing nucleotide phosphoramidates as antiviral agents

Klumpp, Klaus, Martin, Joseph Armstrong, Mcguigan, Christopher, and Smith, David Bernard

PATENT: WO 2007020193 ISSUE DATE: 20070222

APPLICATION: 2006 PP: 145pp.

ASSIGNEE: (F. Hoffmann-La Roche A.-G., Switz.

50. 60527 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of 2'-C-Me nucleoside 5 '-monophosphate and 4'-C-Me nucleoside 5'- monophosphate prodrugs for the treatment of hepatitis C viral infection

Erion, Mark D, Reddy, KRaja, Maccoss, Malcolm, and Olsen, David B

PATENT: WO 2007022073 ISSUE DATE: 20070222

APPLICATION: 2006 PP: 268pp.

ASSIGNEE: (Merck & Co., Inc. USA and Metabasis Therapeutics, Inc.

51. 60528 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of macrocyclic inhibitors of hepatitis C virus

De Kock, Herman Augustinus, Simmen, Kenneth Alan, Joensson, Carl Erik Daniel, Ayesa Alvarez, Susana, Classon, Bjoern Olof, Nilsson, Karl Magnus, Rosenquist, Aasa Annica Kristina, Samuelsson, Bengt Bertil, and Wallberg, Hans Kristian

PATENT: WO 2007014923 ISSUE DATE: 20070208

APPLICATION: 2006 PP: 94pp.

ASSIGNEE: (Tibotec Pharmaceuticals Ltd., Ire. and Medivir AB)

52. 60529 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of macrocyclic carboxylic acids, amides, and acylsulfonamides as inhibitors of HCV replication

Seiwert, Scott D, Blatt, Lawrence M, Andrews, Steven W, Martin, Pierre, Schumacher, Andreas, Barnett, Bradley R, Eary, Todd C, Kaus, Robert, Kercher, Timothy, Liu, Weidong, Lyon, Michael, Nichols, Paul, Wang, Bin, Sammakia, Tarek, Kennedy, April, and Jiang, Yutong

PATENT: WO 2007015824 ISSUE DATE: 20070208

APPLICATION: 2006 PP: 512pp.

ASSIGNEE: (Intermune, Inc. USA and Array Biopharma Inc.)


53. 60530 DMID-LS-141; SCIFINDER-DMID-3/26/2007

6-Membered aryl and heteroaryl derivatives for treating viruses and their preparation and pharmaceutical compositions

Botyanszki, Janos, Shi, Dong-Fang, Roberts, Christopher Don, and Schmitz, Franz Ulrich

PATENT: US 2007032488 ISSUE DATE: 20070208

APPLICATION: 2006-40709 PP: 45pp.

ASSIGNEE: (Genelabs Technologies, Inc. USA

54. 60531 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of peptidyl boronic acid derivatives as hepatitis C serine protease inhibitors

Campbell, David Alan, Winn, David T, Betancort, Juan Manuel, and Hepperle, Michael E

PATENT: WO 2007016476 ISSUE DATE: 20070208

APPLICATION: 2006 PP: 107pp.

ASSIGNEE: (Phenomix Corporation, USA

55. 60532 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Preparation of macrocyclic peptides as HCV NS3 protease inhibitors

Holloway, MKatharine, Liverton, Nigel J, McCauley, John A, Rudd, Michael T, Vacca, Joseph P, Ludmerer, Steven W, and Olsen, David B

PATENT: WO 2007016441 ISSUE DATE: 20070208

APPLICATION: 2006 PP: 210pp.

ASSIGNEE: (Merck & Co., Inc. USA

56. 60533 DMID-LS-141; SCIFINDER-DMID-3/26/2007

Antiviral compositions containing telbivudine salts and their hydrates

Yang, Xihong

PATENT: CN 1903869 ISSUE DATE: 20070131

APPLICATION: 1010-1214 PP: 30pp.

ASSIGNEE: (Peop. Rep. China)

57. 60534 DMID-LS-141; WOS-DMID-3/26/2007

Factors That Affect in Vitro Measurement of the Susceptibility of Herpes Simplex Virus to Nucleoside Analogues

Weinberg, A. et al.

Journal of Clinical Virology 2007. 38(2): 139-145


58. 60535 DMID-LS-141; WOS-DMID-3/26/2007

In Vitro Susceptibility of Hbv Polymerase Encoding Mutations Acquired During Adefovir Dipivoxil Therapy to Other Anti-Hbv Agents

Qi, X. et al.

Hepatology 2006. 44(4): 252A-253A


59. 60536 DMID-LS-141; WOS-DMID-3/26/2007

Antimicrobial Peptides as New Recognition Molecules for Screening Challenging Species

Kulagina, N. et al.

Sensors and Actuators B-Chemical 2007. 121(1): 150-157


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