1. A Novel Central Nervous System-penetrating Protease Inhibitor Overcomes Human Immunodeficiency Virus 1 Resistance with Unprecedented aM to pM Potency. Aoki, M., H. Hayashi, K.V. Rao, D. Das, N. Higashi-Kuwata, H. Bulut, H. Aoki-Ogata, Y. Takamatsu, R.S. Yedidi, D.A. Davis, S.I. Hattori, N. Nishida, K. Hasegawa, N. Takamune, P.R. Nyalapatla, H.L. Osswald, H. Jono, H. Saito, R. Yarchoan, S. Misumi, A.K. Ghosh, and H. Mitsuya. eLife, 2017. 6: e28020. PMID[29039736]. PMCID[PMC5644950].
[PubMed]. HIV_10_2017.
2. 1H-Tetrazol-5-amine and 1,3-Thiazolidin-4-one Derivatives Containing 3-(Trifluoromethyl)phenyl Scaffold: Synthesis, Cytotoxic and anti-HIV Studies.Bielenica, A., D. Szulczyk, W. Olejarz, S. Madeddu, G. Giliberti, I.B. Materek, A.E. Koziol, and M. Struga. Biomedecine & Pharmacotherapie, 2017. 94: p. 804-812. PMID[28802233].
[PubMed]. HIV_10_2017.
3. Effects of HIV-1 gp41-derived Virucidal Peptides on Virus-like Lipid Membranes. Carravilla, P., A. Cruz, I. Martin-Ugarte, I.R. Oar-Arteta, J. Torralba, B. Apellaniz, J. Perez-Gil, J. Requejo-Isidro, N. Huarte, and J.L. Nieva. Biophysical Journal, 2017. 113(6): p. 1301-1310. PMID[28797705]. PMCID[PMC5607204].
[PubMed]. HIV_10_2017.
4. Sundarbanxylogranins A-E, Five New Limonoids from the Sundarban Mangrove, Xylocarpus granatum. Dai, Y.G., J. Wu, K.P. Padmakumar, and L. Shen. Fitoterapia, 2017. 122: p. 85-89. PMID[28864040].
[PubMed]. HIV_10_2017.
5. 1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as Novel Selective HIV Integrase Inhibitors Obtained via Privileged Substructure-based Compound Libraries. 95. Gao, P., L. Zhang, L. Sun, T. Huang, J. Tan, J. Zhang, Z. Zhou, T. Zhao, L. Menendez-Arias, C. Pannecouque, E. Clercq, P. Zhan, and X. Liu. Bioorganic & Medicinal Chemistry, 2017. 25(20): p. 5779-5789. PMID[28951095].
[PubMed]. HIV_10_2017.
6. Design of Novel HIV-1 Protease Inhibitors Incorporating Isophthalamide-derived P2-P3 Ligands: Synthesis, Biological Evaluation and X-ray Structural Studies of Inhibitor-HIV-1 Protease Complex. Ghosh, A.K., M. Brindisi, P.R. Nyalapatla, J. Takayama, J.R. Ella-Menye, S. Yashchuk, J. Agniswamy, Y.F. Wang, M. Aoki, M. Amano, I.T. Weber, and H. Mitsuya. Bioorganic & Medicinal Chemistry, 2017. 25(19): p. 5114-5127. PMID[28434781]. PMCID[PMC5617771].
[PubMed]. HIV_10_2017.
7. Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys. Julg, B., D. Sok, S.D. Schmidt, P. Abbink, R.M. Newman, T. Broge, C. Linde, J. Nkolola, K. Le, D. Su, J. Torabi, M. Pack, A. Pegu, T.M. Allen, J.R. Mascola, D.R. Burton, and D.H. Barouch. Journal of Virology, 2017. 91(20): e01187-01117. PMID[28768869]. PMCID[PMC5625479].
[PubMed]. HIV_10_2017.
8. Triterpenoids from Ocimum labiatum Activates Latent HIV-1 Expression in Vitro: Potential for Use in Adjuvant Therapy.Kapewangolo, P., J.J. Omolo, P. Fonteh, M. Kandawa-Schulz, and D. Meyer. Molecules, 2017. 22(10): E1703. PMID[29027985].
[PubMed]. HIV_10_2017.
9. In Vivo Suppression of HIV Rebound by Didehydro-cortistatin a, a "Block-and-lock" Strategy for HIV-1 Treatment. Kessing, C.F., C.C. Nixon, C. Li, P. Tsai, H. Takata, G. Mousseau, P.T. Ho, J.B. Honeycutt, M. Fallahi, L. Trautmann, J.V. Garcia, and S.T. Valente. Cell Reports, 2017. 21(3): p. 600-611. PMID[29045830].
[PubMed]. HIV_10_2017.
10. Expression of an RNA Glycosidase Inhibits HIV-1 Transactivation of Transcription. Kutky, M. and K.A. Hudak. The Biochemical Journal, 2017. 474(20): p. 3471-3483. PMID[28864671].
[PubMed]. HIV_10_2017.
11. HLA-B*14:02-restricted Env-specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection. Leitman, E.M., C.B. Willberg, M.H. Tsai, H. Chen, S. Buus, F. Chen, L. Riddell, D. Haas, J. Fellay, J.J. Goedert, A. Piechocka-Trocha, B.D. Walker, J. Martin, S. Deeks, S.M. Wolinsky, J. Martinson, M. Martin, Y. Qi, A. Saez-Cirion, O.O. Yang, P.C. Matthews, M. Carrington, and P.J.R. Goulder. Journal of Virology, 2017. 91(22): e00544-00517. PMID[28878089]. PMCID[PMC5660483].
[PubMed]. HIV_10_2017.
12. Inhibition of HIV-1 Infection in Humanized Mice and Metabolic Stability of Protein Phosphatase-1-targeting Small Molecule 1E7-03. Lin, X.H., N. Kumari, C. DeMarino, Y.S. Kont, T. Ammosova, A. Kulkarni, M. Jerebtsova, G. Vazquez-Meves, A. Ivanov, D. Kovalskyy, A. Uren, F. Kashanchi, and S. Nekhai. Oncotarget, 2017. 8(44): p. 76749-76769. ISI[000412066700079].
[WOS]. HIV_10_2017.
13. Host microRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor. Lodge, R., J.A. Ferreira Barbosa, F. Lombard-Vadnais, J.C. Gilmore, A. Deshiere, A. Gosselin, T.R. Wiche Salinas, M.G. Bego, C. Power, J.P. Routy, P. Ancuta, M.J. Tremblay, and E.A. Cohen. Cell Reports, 2017. 21(1): p. 141-153. PMID[28978468].
[PubMed]. HIV_10_2017.
14. Synthesis, Crystal Structure, anti-HIV, and Antiproliferative Activity of New Pyrazolylthiazole Derivatives. Madni, M., S. Hameed, M.N. Ahmed, M.N. Tahir, N.A. Al-Masoudi, and C. Pannecouque. Medicinal Chemistry Research, 2017. 26(10): p. 2653-2665. ISI[000412416600037].
[WOS]. HIV_10_2017.
15. Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-associated Kinase Regulates HIV-1 Motility and Uncoating. Malikov, V. and M.H. Naghavi. Cell Reports, 2017. 20(12): p. 2792-2799. PMID[28930676].
[PubMed]. HIV_10_2017.
16. Role of Angiopoietin-2, Endoglin, and Placental Growth Factor in HIV-associated Preeclampsia. Mbhele, N., J. Moodley, and T. Naicker. Hypertension in Pregnancy, 2017. 36(3): p. 240-246. PMID[28627965].
[PubMed]. HIV_10_2017.
17. Crystal Structure of an Engineered, HIV-specific Recombinase for Removal of Integrated Proviral DNA. Meinke, G., J. Karpinski, F. Buchholz, and A. Bohm. Nucleic Acids Research, 2017. 45(16): p. 9726-9740. PMID[28934476].
[PubMed]. HIV_10_2017.
18. Dimerization Regulates Both Deaminase-dependent and Deaminase-independent HIV-1 Restriction by APOBEC3G. Morse, M., R. Huo, Y.Q. Feng, I. Rouzina, L. Chelico, and M.C. Williams. Nature Communications, 2017. 8: p. 597. PMID[28928403]. PMCID[PMC5605669].
[PubMed]. HIV_10_2017.
19. The Potential of Moringa oleifera Lam. To Manage HIV-1 Infections and Its Positive Pharmaco-synergy with Antiretroviral Therapies. Ndhlala, A.R., K. Cele, R. Mulaudzi, P.C.P. du, S. Venter, P.W. Mashela, and H.A. Abdelgadir. Planta Medica, 2016. 82. ISI[000411789300155].
[WOS]. HIV_10_2017.
20. Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata. Nothias, L.F., S. Boutet-Mercey, X. Cachet, E. De La Torre, L. Laboureur, J.F. Gallard, P. Retailleau, A. Brunelle, P.C. Dorrestein, J. Costa, L.M. Bedoya, F. Roussi, P. Leyssen, J. Alcami, J. Paolini, M. Litaudon, and D. Touboul. Journal of Natural Products, 2017. 80(10): p. 2620-2629. PMID[28925702].
[PubMed]. HIV_10_2017.
21. The Role of the Glycosyl Moiety of Myricetin Derivatives in anti-HIV-1 Activity in Vitro. Ortega, J.T., A.I. Suarez, M.L. Serrano, J. Baptista, F.H. Pujol, and H.R. Rangel. AIDS Research and Therapy, 2017. 14: p. 57. PMID[29025433]. PMCID[PMC5639754].
[PubMed]. HIV_10_2017.
22. Antiviral Screening of Microbial Natural Products. Overacker, R.D. and S. Loesgen. Planta Medica, 2016. 82. ISI[000411789300112].
[WOS]. HIV_10_2017.
23. A Search for Dual Action HIV-1 Reverse Transcriptase, Bacterial RNA Polymerase Inhibitors. Paneth, A., T. Fraczek, A. Grzegorczyk, D. Janowska, A. Malm, and P. Paneth. Molecules, 2017. 22(11): E1808. PMID[29068373].
[PubMed]. HIV_10_2017.
24. Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and their anti-HIV Activities. Pang, X., J.Y. Zhao, X.M. Fang, T. Zhang, D.W. Zhang, H.Y. Liu, J. Su, S. Cen, and L.Y. Yu. Journal of Natural Products, 2017. 80(10): p. 2595-2601. PMID[29016131].
[PubMed]. HIV_10_2017.
25. Chemical Optimization of Macrocyclic HIV-1 Inactivators for Improving Potency and Increasing the Structural Diversity at the Triazole Ring. Rashad, A.A., K. Acharya, A. Haftl, R. Aneja, A. Dick, A.P. Holmes, and I. Chaiken. Organic & Biomolecular Chemistry, 2017. 15(37): p. 7770-7782. PMID[28770939]. PMCID[PMC5614861].
[PubMed]. HIV_10_2017.
26. Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection. Schaller, T., L. Bulli, D. Pollpeter, G. Betancor, J. Kutzner, L. Apolonia, N. Herold, R. Burk, and M.H. Malim. Journal of Virology, 2017. 91(19): e00463-00417. PMID[28747499]. PMCID[PMC5599759].
[PubMed]. HIV_10_2017.
27. Unique Binding Modes for the Broad Neutralizing Activity of Single-chain Variable Fragments (SCFV) Targeting CD4-induced Epitopes. Tanaka, K., T. Kuwata, M. Alam, G. Kaplan, S. Takahama, K.P.R. Valdez, A. Roitburd-Berman, J.M. Gershoni, and S. Matsushita. Retrovirology, 2017. 14: p. 44. PMID[28938888]. PMCID[PMC5610415].
[PubMed]. HIV_10_2017.
28. Multipurpose Tenofovir disoproxil fumarate Electrospun Fibers for the Prevention of HIV-1 and HSV-2 Infections in Vitro. Tyo, K.M., H.R. Vuong, D.A. Malik, L.B. Sims, H. Alatassi, J. Duan, W.H. Watson, and J.M. Steinbach-Rankins. International Journal of Pharmaceutics, 2017. 531(1): p. 118-133. PMID[28797967].
[PubMed]. HIV_10_2017.
29. Anti-HIV Natural Products (28): Preparation of Conjugate for 3-O-Acyl betulin Derivative and AZT as anti-HIV Agents. Wada, S., N. Tanaka, C.H. Chen, S.L. Morris-Natschke, K.H. Lee, and Y. Kashiwada. Planta Medica, 2016. 82. ISI[000411789300606].
[WOS]. HIV_10_2017.
30. Human SMOOTHENED Inhibits Human Immunodeficiency Virus Type 1 Infection. Yoshida, T., A. Hamano, A. Ueda, H. Takeuchi, and S. Yamaoka. Biochemical and Biophysical Research Communications, 2017. 493(1): p. 132-138. PMID[28917838].
[PubMed]. HIV_10_2017.
31. Krishnolides A-D: New 2-Ketokhayanolides from the Krishna Mangrove, Xylocarpus moluccensis. Zhang, Q., T. Satyanandamurty, L. Shen, and J. Wu. Marine Drugs, 2017. 15(11): E333. PMID[29077062].
[PubMed]. HIV_10_2017.
32. Crosstalk between Histone Modifications Indicates that Inhibition of Arginine methyltransferase CARM1 Activity Reverses HIV Latency. Zhang, Z., B.C. Nikolai, L.A. Gates, S.Y. Jung, E.B. Siwak, B. He, A.P. Rice, B.W. O'Malley, and Q. Feng. Nucleic Acids Research, 2017. 45(16): p. 9348-9360. PMID[28637181].
[PubMed]. HIV_10_2017.
33. Bioactive Steroids and Sorbicillinoids Isolated from the Endophytic Fungus Trichoderma sp. Xy24. Zhao, J.L., M. Zhang, J.M. Liu, Z. Tan, R.D. Chen, K.B. Xie, and J.G. Dai. Journal of Asian Natural Products Research, 2017. 19(10): p. 1028-1035. PMID[28145126].
[PubMed]. HIV_10_2017.
Patent Citations
This month, no relevant HIV patents were identified.