1. Pyromellitic dianhydride Crosslinked Soluble Cyclodextrin Polymers: Synthesis, Lopinavir Release from Sub-micron Sized Particles and anti-HIV-1 Activity. Adeoye, O., I. Bartolo, J. Conceicao, A.B. da Silva, N. Duarte, A.P. Francisco, N. Taveira, and H. Cabral-Marques. International Journal of Pharmaceutics, 2020. 583: 119356. PMID[32325245].
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2. The Inhibitor of Apoptosis Proteins Antagonist Debio 1143 Promotes the PD-1 Blockade-mediated HIV Load Reduction in Blood and Tissues of Humanized Mice. Bobardt, M., J. Kuo, U. Chatterji, N. Wiedemann, G. Vuagniaux, and P. Gallay. Plos One, 2020. 15(1): e0227715. PMID[31978106]. PMCID[PMC6980394].
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3. Single Atom Changes in Newly Synthesized HIV Protease Inhibitors Reveal Structural Basis for Extreme Affinity, High Genetic Barrier, and Adaptation to the HIV Protease Plasticity. Bulut, H., S.I. Hattori, H. Aoki-Ogata, H. Hayashi, D. Das, M. Aoki, D.A. Davis, K.V. Rao, P.R. Nyalapatla, A.K. Ghosh, and H. Mitsuya. Scientific Reports, 2020. 10(1): 10664. PMID[32606378]. PMCID[PMC7326966].
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4. A Class of Potent Inhibitors of the HIV-1 Nucleocapsid Protein Based on Aminopyrrolic Scaffolds. Ciaco, S., N. Humbert, E. Real, C. Boudier, O. Francesconi, S. Roelens, C. Nativi, C. Seguin-Devaux, M. Mori, and Y. Mely. ACS Medicinal Chemistry Letters, 2020. 11(5): p. 698-705. PMID[32435373]. PMCID[PMC7236033].
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5. Identification of Combinations of Protein Kinase C Activators and Histone Deacetylase Inhibitors That Potently Reactivate Latent HIV. Curreli, F., S. Ahmed, S.M.B. Victor, and A.K. Debnath. Viruses, 2020. 12(6): E609. PMID[32503121].
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6. PF74 and Its Novel Derivatives Stabilize Hexameric Lattice of HIV-1 Mature-like Particles. Dostalkova, A., K. Skach, F. Kaufman, I. Krizova, R. Hadravova, M. Flegel, T. Ruml, R. Hrabal, and M. Rumlova. Molecules, 2020. 25(8): 1895. PMID[32325987]. PMCID[PMC7221806].
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7. Multiple in Vitro Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA. Gamba, E., A. Sosic, I. Saccone, E. Magli, F. Frecentese, and B. Gatto. ACS Medicinal Chemistry Letters, 2020. 11(5): p. 949-955. PMID[32435410]. PMCID[PMC7236229].
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8. A Trispecific anti-HIV Chimeric Antigen Receptor Containing the CCR5 N-Terminal Region. Hajduczki, A., D.T. Danielson, D.S. Elias, V. Bundoc, A.W. Scanlan, and E.A. Berger. Frontiers in Cellular and Infection Microbiology, 2020. 10: 242. PMID[32523897]. PMCID[PMC7261873].
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9. Design, Synthesis and Biological Evaluation of Novel 5-((Substituted Quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 Fusion Inhibitors. Ibrahim, T.S., R.M. Bokhtia, A.M.M. Al-Mahmoudy, E.S. Taher, M.A. AlAwadh, M. Elagawany, E.H. Abdel-Aal, S. Panda, A.M. Gouda, H.Z. Asfour, N.A. Alhakamy, and B.G.M. Youssif. Bioorganic Chemistry, 2020. 99: 103782. PMID[32229348].
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10. Anti-HIV-active Nucleoside Triphosphate Prodrugs. Jia, X., D. Schols, and C. Meier. Journal of Medicinal Chemistry, 2020. 63(11): p. 6003-6027. PMID[32421343].
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11. Exploring the Hydrophobic Channel of NNIBP Leads to the Discovery of Novel Piperidine-substituted Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs. Kang, D.W., D. Feng, T. Ginex, J.M. Zou, F.J. Wei, T. Zhao, B.S. Huang, Y.Y. Sun, S. Desta, E. De Clercq, C. Pannecouque, P. Zhan, and X.Y. Liu. Acta Pharmaceutica Sinica B, 2020. 10(5): p. 878-894. PMID[32528834]. PMCID[PMC7280082].
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12. Structure-based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-resistance Profiles and Favorable Pharmacokinetic Properties. Kang, D.W., D. Feng, Y.Y. Sun, Z.J. Fang, F.J. Wei, E. De Clercq, C. Pannecouque, X.Y. Liu, and P. Zhan. Journal of Medicinal Chemistry, 2020. 63(9): p. 4837-4848. PMID[32293182].
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13. Quantifying the Antiviral Effect of APOBEC3 on HIV-1 Infection in Humanized Mouse Model. Kurusu, T., K.S. Kim, Y. Koizumi, S. Nakaoka, K. Ejima, N. Misawa, Y. Koyanagi, K. Sato, and S. Iwami. Journal of Theoretical Biology, 2020. 498: 110295. PMID[32335137].
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14. Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle. Le, N.T., D.V. Ho, T.Q. Doan, A.T. Le, A. Raal, D. Usai, G. Sanna, A. Carta, P. Rappelli, N. Diaz, P. Cappuccinelli, S. Zanetti, H.T. Nguyen, and M.G. Donadu. Antibiotics, 2020. 9(4): 207. PMID[32344551]. PMCID[PMC7235712].
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15. A Novel lncRNA, AK130181, Contributes to HIV-1 Latency by Regulating Viral Promoter-driven Gene Expression in Primary CD4(+) T Cells. Li, H.Y., X.B. Chi, R. Li, J. Ouyang, and Y.K. Chen. Molecular Therapy-Nucleic Acids, 2020. 20: p. 754-763. PMID[32408053]. PMCID[PMC7225600].
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16. Bioactive Ent-Isopimarane Diterpenoids from Euphorbia neriifolia. Li, J.C., W.F. Dai, D. Liu, M.Y. Jiang, Z.J. Zhang, X.Q. Chen, C.H. Chen, R.T. Li, and H.M. Li. Phytochemistry, 2020. 175: 112373. PMID[32305684].
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17. Design, Synthesis, and Evaluation of Novel CXCR4 Antagonists Based on an Aminoquinoline Template. Lin, Y., Z. Li, C. Xu, K. Xia, S. Wu, Y. Hao, Q. Yang, H. Ma, J. Zheng, L. Luo, F. Zhu, S. He, and X. Zhang. Bioorganic Chemistry, 2020. 99: 103824. PMID[32334192].
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18. Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines. Lin, Y., Z.H. Li, H.K. Ma, Y.J. Wang, X. Wang, S.W. Song, L. Zhao, S.W. Wu, S. Tian, C.Y. Fu, L.S. Luo, F. Zhu, S.D. He, J.Y. Zheng, and X.H. Zhang. ChemMedChem, 2020. 15(13):1150-1162. PMID[32391652].
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19. 5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein. Malancona, S., M. Mori, P. Fezzardi, M. Santoriello, A. Basta, M. Nibbio, L. Kovalenko, R. Speziale, M.R. Battista, A. Cellucci, N. Gennari, E. Monteagudo, A. Di Marco, A. Giannini, R. Sharma, M. Pires, E. Real, M. Zazzi, M.C.D. Lang, D. De Forni, F. Saladini, Y. Mely, V. Summa, S. Harper, and M. Botta. ACS Medicinal Chemistry Letters, 2020. 11(5): p. 766-772. PMID[32435383]. PMCID[PMC7236274].
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20. Inhibition of Human Immunodeficiency Virus Type 1 by Niclosamide through MTORC1 Inhibition. Niyomdecha, N., O. Suptawiwat, C. Boonarkart, K. Jitobaom, and P. Auewarakul. Heliyon, 2020. 6(6): e04050. PMID[32529067]. PMCID[PMC7276449].
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21. Inhibition of HIV-1 Protease by Carpobrotus edulis (L.). Omoruyi, B.E., D.I. Ighodaro, A.J. Afolayan, and G. Bradley. Evidence-Based Complementary and Alternative Medicine, 2020. 2020: 9648056. PMID[32595755]. [PMC7298281].
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22. Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts. Sanna, G., S. Madeddu, G. Murgia, G. Serreli, M. Begala, P. Caboni, A. Incani, G. Franci, M. Galdiero, and G. Giliberti. Viruses, 2020. 12(6): E664. PMID[32575585].
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23. Inhibition of Human Immunodeficiency Virus-1 Integrase by beta-Diketo acid Coated Gold Nanoparticles. Sanna, V., M.F. Youssef, N. Pala, D. Rogolino, M. Carcelli, P.K. Singh, T. Sanchez, N. Neamati, and M. Sechi. ACS Medicinal Chemistry Letters, 2020. 11(5): p. 857-861. PMID[32435396]. PMCID[PMC7236234].
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24. N-P-tosyl-L-Phenylalanine chloromethyl ketone (TPCK) Inhibits HIV-1 by Suppressing the Activity of Viral Protease. Trivedi, J., P. Ghosh, and D. Mitra. Biochemical and Biophysical Research Communications, 2020. 527(1): p. 167-172. PMID[32446362].
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25. Exploratory Studies on CA-15L, an anti-HIV Active HIV-1 Capsid Fragment. Tsuji, K., K.B. Owusu, T. Kobayakawa, R. Wang, M. Fujino, M. Kaneko, N. Yamamoto, T. Murakami, and H. Tamamura. Bioorganic & Medicinal Chemistry, 2020. 28(11): 115488. PMID[32305183].
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26. An Amphipathic Peptide Targeting the GP41 Cytoplasmic Tail Kills HIV-1 Virions and Infected Cells. Wang, Q., S. Su, J. Xue, F. Yu, J. Pu, W. Bi, S. Xia, Y. Meng, C. Wang, W. Yang, W. Xu, Y. Zhu, Q. Zheng, C. Qin, S. Jiang, and L. Lu. Science Translational Medicine, 2020. 12(546): eaaz2254. PMID[32493792].
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27. Privileged Scaffold Inspired Design of Novel Oxime-biphenyl-DAPYs in Treatment of HIV-1. Yang, Y., C. Pannecouque, E. Clercq, C. Zhuang, and F.E. Chen. Bioorganic Chemistry, 2020. 99: 103825. PMID[32334191].
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28. Discovery of Ethyl Ketone-based HDACs 1, 2, and 3 Selective Inhibitors for HIV Latency Reactivation. Yu, W.S., J. Liu, Y.N. Yu, V. Zhang, D. Clausen, J. Kelly, S. Wolkenberg, D. Beshore, J.L. Duffy, C.C. Chung, R.W. Myers, D.J. Klein, J. Fells, K. Holloway, J. Wu, G.X. Wu, B.J. Howell, R.J.O. Barnard, and J. Kozlowski. Bioorganic & Medicinal Chemistry Letters, 2020. 30(13): 127197. PMID[32331932].
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