HIV Citations List: May 2025

Literature Citations

1. Integrating Different Approaches for the Identification of New Disruptors of HIV-1 Capsid Multimerization. Artía, Z., C. Guillon, X. Robert, M. Granzella, A.C. Segovia, H.H. Truong, G. Álvarez, I. Corvo, and L. Randall-Carlevaro. Biochemical and Biophysical Research Communications, 2025. 763: p. 151572. PMID[40239540].
[PubMed]. HIV_05_2025.

2. Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir. Briganti, L., A.S. Annamalai, S.M. Bester, G. Wei, J.R. Andino-Moncada, S.P. Singh, A.B. Kleinpeter, M. Tripathi, B. Nguyen, R. Radhakrishnan, P.K. Singh, J. Greenwood, L.I. Schope, R. Haney, S.W. Huang, E.O. Freed, A.N. Engelman, A.C. Francis, and M. Kvaratskhelia. mBio, 2025. 16(5): p. e0361324. PMID[40231850]. PMCID[PMC12077090].
[PubMed]. HIV_05_2025.

3. CPSF6 Promotes HIV-1 Preintegration Complex Function. Chaudhuri, E., S. Jang, R. Chakraborty, R. Radhakrishnan, B. Arnarson, P. Prakash, D. Cornish, N. Rohlfes, P.K. Singh, J. Shi, C. Aiken, E. Campbell, J. Hultquist, M. Balsubramaniam, A.N. Engelman, and C. Dash. Journal of Virology, 2025. 99(5): p. e0049025. PMID[40202316]. PMCID[PMC12090733].
[PubMed]. HIV_05_2025.

4. Potent HIV‑1 Protease Inhibitors Containing Oxabicyclo Octanol-Derived P2-Ligands: Design, Synthesis, and X‑Ray Structural Studies of Inhibitor-HIV-1 Protease Complexes. Ghosh, A.K., M. Yadav, A. Sharma, M. Johnson, A.K. Ghosh, R. Prasad, M. Amano, O. Gerlits, A. Kovalevsky, and H. Mitsuya. Bioorganic Medicinal Chemistry Letters, 2025. 120: p. 130109. PMID[39848476]. PMCID[PMC11956850].
[PubMed]. HIV_05_2025.

5. EZH2 Inhibition Mitigates HIV Immune Evasion, Reduces Reservoir Formation, and Promotes Skewing of CD8(+) T Cells toward Less-Exhausted Phenotypes. Gramatica, A., I.G. Miller, A.R. Ward, F. Khan, T.J. Kemmer, J. Weiler, T.T. Huynh, P. Zumbo, A.P. Kurland, L. Leyre, Y. Ren, T. Klevorn, D.C. Copertino, U. Chukwukere, C. Levinger, T.R. Dilling, N. Linden, N.L. Board, E. Falling Iversen, S. Terry, T.M. Mota, S. Bedir, K.L. Clayton, A. Bosque, L. MacLaren Ehui, C. Kovacs, D. Betel, J.R. Johnson, M. Paiardini, A. Danesh, and R.B. Jones. Cell Reports, 2025. 44(5): p. 115652. PMID[40333189].
[PubMed]. HIV_05_2025.

6. Impact of HIV-1 Capsid Polymorphisms on Viral Infectivity and Susceptibility to Lenacapavir. Hansen, D., M.R. Hendricks, S. Chang, A. Cai, J.K. Perry, T. Aeschbacher, R. Martin, T. Cihlar, and S.R. Yant. mBio, 2025. 16(5): p. e0018725. PMID[40243329]. PMCID[PMC12077089].
[PubMed]. HIV_05_2025.

7. ABT-263, a BCL-2 Inhibitor, Selectively Eliminates Latently HIV-1-Infected Cells without Viral Reactivation. Kang, J.E., H.W. Seo, D.E. Kim, Y.H. Shin, S. Bae, and C.H. Yoon. PLoS One, 2025. 20(5): p. e0322962. PMID[40392781]. PMCID[PMC12091775].
[PubMed]. HIV_05_2025.

8. The Synthesis and Investigation of Novel 3-Benzoylbenzofurans and Pyrazole Derivatives for Anti-HIV Activity. Khuzwayo, S.S., M.A. Selepe, D. Meyer, and N.H. Gama. RSC Medicinal Chemistry, 2025. 16(5): p. 2142-2158. PMID[40060998]. PMCID[PMC11883425].
[PubMed]. HIV_05_2025.

9. Suppression of HIV-1 Transcription and Latency Reversal Via Ectopic Expression of the Viral Antisense Transcript AST. Li, R., K. Daneshvar, X. Ji, M. Pleet, G. Igbinosun, M.S. Iqbal, F. Kashanchi, A.C. Mullen, and F. Romerio. Science Advances, 2025. 11(19): p. eadu8014. PMID[40344061]. PMCID[PMC12063652].
[PubMed]. HIV_05_2025.

10. Single-Cell Multi-Omics Profiling Uncovers the Immune Heterogeneity in HIV-Infected Immunological Non-Responders. Liu, X., L. Zhang, X. Li, L. Chen, L. Lu, Y. Yang, Y. Wu, L. Zheng, J. Tang, F. Wang, Y. Han, X. Song, W. Cao, and T. Li. eBioMedicine, 2025. 115: p. 105667. PMID[40184908]. PMCID[PMC12002939].
[PubMed]. HIV_05_2025.

11. BRD9 Functions as an HIV-1 Latency Regulatory Factor. Luk, T.Y., L.Y. Yim, R. Zhou, Y. Mo, H. Huang, M. Zhao, J. Dai, T.T. Lau, X. Huang, G.C. Lui, K.Y. Yuen, J.F. Chan, A.S. Cheng, Z. Chen, and H. Chu. Proceedings of the National Academy of Sciences of the United States of America, 2025. 122(21): p. e2418467122. PMID[40402245]. PMCID[PMC12130862].
[PubMed]. HIV_05_2025.

12. Higher Proportions of Circulating CXCR3+ CCR6- Tfh Cells as a Hallmark of Impaired CD4+ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders. Nagaraju, R., P.S. Gowda, D.M. Gunasekaran, A.S. Desai, U. Ranga, R.N.R. Masthi, and M.M. Venkataswamy. mBio, 2025. 16(5): p. e0057525. PMID[40130906]. PMCID[PMC12077124].
[PubMed]. HIV_05_2025.

13. BRD4 Modulator ZL0580 and Ledgins Additively Block and Lock HIV-1 Transcription. Pellaers, E., J. Janssens, L. Wils, A. Denis, A. Bhat, S. Van Belle, D. Feng, F. Christ, P. Zhan, and Z. Debyser. Nature Communications, 2025. 16(1): p. 4226. PMID[40335477]. PMCID[PMC12059001].
[PubMed]. HIV_05_2025.

14. Potent HIV-1 Miniprotein Inhibitors Targeting Highly Conserved gp41 Epitopes. Polo-Megías, D., M. Cano-Muñoz, P. Gantner, G. Laumond, T. Decoville, J. Grezzani, I. La Rocchia, M.C. Salinas-Garcia, A. Cámara-Artigas, J.A. Gavira, F. Conejero-Lara, and C. Moog. International Journal of Biological Macromolecules, 2025. 310(Pt 1): p. 143157. PMID[40239787].
[PubMed]. HIV_05_2025.

15. Ex Vivo and in Vivo Hiv-1 Latency Reversal by "Mukungulu," a Protein Kinase C-Activating African Medicinal Plant Extract. Richard, K., Z. Yuan, H.Y. Tang, A.R. Goldman, R. Kuthu, B. Raphane, E.T. Register, P. Sharma, B.N. Ross, J. Morris, D.E. Williams, C. Cheney, G. Wu, K. Mounzer, G.M. Laird, P. Zuck, R.J. Andersen, S. Simonambango, K. Andrae-Marobela, I. Tietjen, and L.J. Montaner. mBio, 2025. 16(5): p. e0381624. PMID[40265896]. PMCID[PMC12077168].
[PubMed]. HIV_05_2025.

16. Analysis of Raltegravir Analogs to Enhance Inhibitory Efficiency against HIV Integrase. Sabaghian, H. and M. Yoosefian. Scientific Reports, 2025. 15(1): p. 16665. PMID[40360594]. PMCID[PMC12075693].
[PubMed]. HIV_05_2025.

17. Development of Enhanced HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Resistance and Pharmacokinetic Profiles. Wang, Z., S. Rumrill, D. Kang, S.D. Guma, D. Feng, E. De Clercq, C. Pannecouque, C.H. Chen, E. Arnold, F.X. Ruiz, X. Liu, and P. Zhan. Science Advances, 2025. 11(22): p. eadt8916. PMID[40446037]. PMCID[PMC12124364].
[PubMed]. HIV_05_2025.

18. Afucosylated Broadly Neutralizing Antibodies Targeting the HIV Envelope Elicit Enhanced NK-Cell-Mediated Cytotoxicity against HIV-Infected CD4+ T-Cell and Macrophage Targets. Wilhelm, O., C. Jordan, H. Kek, M.M. Brunton-O'Sullivan, L. Rikard-Bell, P. Ramanathan, A.W. Chung, P. Poumbourios, B.D. Wines, A. Jaworowski, and A.C. Hearps. Journal of Leukocyte Biology, 2025. 117(5). PMID[40086815]. PMCID[PMC12080361].
[PubMed]. HIV_05_2025.

19. RYBP Promotes HIV-1 Latency through Promoting H2AK119ub and Decreasing H3K4me3. Yang, X., Y. Zhu, X. Zhao, J. Xun, X. Wang, Y. Cheng, S. Xiong, X. Yu, S. Li, D. Wang, Z. Hu, Y. Shen, S. Jiang, H. Lu, G. Wang, and H. Zhu. Cell Communication and Signaling, 2025. 23(1): p. 222. PMID[40361117]. PMCID[PMC12070685].
[PubMed]. HIV_05_2025.

20. Structure-Based Design of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent HIV-1 NNRTIs by Exploiting the Tolerant Regions in NNRTIs Binding Pocket. Zhou, Z., M. Xie, Z. Zhuo, Y. Wang, F. Zhao, S. Tao, Z. Liang, E. De Clercq, C. Pannecouque, P. Zhan, D. Kang, and X. Liu. European Journal of Medicinal Chemistry, 2025. 289: p. 117464. PMID[40048799].
[PubMed]. HIV_05_2025.

Patent Citations

This month, no relevant HIV patents were identified.