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1. 44662 OI-LS-313; PUBMED-OI-1/11/2004

Clinical utility of antifungal pharmacokinetics and pharmacodynamics

Andes, D

Curr Opin Infect Dis 2004. 17(6): 533-40


2. 44663 OI-LS-313; PUBMED-OI-1/11/2004

Antitubercular activity of triterpenoids from asteraceae flowers

Akihisa, T, Franzblau, SG, Ukiya, M, Okuda, H, Zhang, F, Yasukawa, K, Suzuki, T, and Kimura, Y

Biol Pharm Bull 2005. 28(1): 158-60


3. 44664 OI-LS-313; PUBMED-OI-1/11/2004

IFN-{alpha}{beta} Secreted during Infection Is Necessary but Not Sufficient for Negative Feedback Regulation of IFN-{alpha}{beta} Signaling by Mycobacterium tuberculosis

Prabhakar, S, Qiao, Y, Canova, A, Tse, DB, and Pine, R

J Immunol 2005. 174(2): 1003-1012


4. 44665 OI-LS-313; PUBMED-OI-1/11/2004

Evaluation of Mycograb(R), amphotericin B, caspofungin, and fluconazole in combination against Cryptococcus neoformans by checkerboard and time-kill methodologies

Nooney, L, Matthews, RC, and Burnie, JP

Diagn Microbiol Infect Dis 2005. 51(1): 19-29


5. 44666 OI-LS-313; PUBMED-OI-1/11/2004

The Crystal Structure of Mycobacterium tuberculosis Thymidylate Kinase in Complex with 3'-Azidodeoxythymidine Monophosphate Suggests a Mechanism for Competitive Inhibition(,)

Fioravanti, E, Adam, V, Munier-Lehmann, H, and Bourgeois, D

Biochemistry 2005. 44(1): 130-137


6. 44667 OI-LS-313; SCIFINDER-OI-1/5/2005

Phosphatidylinositol 3-Kinase and Frabin Mediate Cryptosporidium parvum Cellular Invasion via Activation of Cdc42

Chen, Xian-Ming, Splinter, Patrick L, Tietz, Pamela S, Huang, Bing Q, Billadeau, Daniel D, and LaRusso, Nicholas F

Journal of Biological Chemistry 2004. 279(30): 31671-31678

7. 44668 OI-LS-313; PUBMED-OI-1/11/2004

Further Acquisition of Drug-Resistance in Multidrug-Resistant Tuberculosis during Chemotherapy

Toyota, E, Sekiguchi, J, Shimizu, H, Fujino, T, Otsuka, Y, Yoshikura, H, Kuratsuji, T, Kirikae, T, and Kudo, K

Jpn J Infect Dis 2004. 57(6): 292-4


8. 44669 OI-LS-313; PUBMED-OI-1/11/2004

Antimycobacterial Compounds from Piper sanctum

Mata, R, Morales, I, Perez, O, Rivero-Cruz, I, Acevedo, L, Enriquez-Mendoza, I, Bye, R, Franzblau, S, and Timmermann, B

J Nat Prod 2004. 67(12): 1961-1968


9. 44670 OI-LS-313; SCIFINDER-OI-1/5/2005

In vitro activity on Cryptosporidium parvum oocyst of different drugs with recognized anticryptosporidial efficacy

Castro-Hermida, JA, Pors, I, Ares-Mazas, E, and Chartier, C

Revue de Medecine Veterinaire (Toulouse, France) 2004. 155(8-9): 453-456

10. 44671 OI-LS-313; SCIFINDER-OI-1/5/2005

In Vitro Antibacterial and Antifungal Activities of Extracts and Compounds from Uvaria scheffleri

Moshi, Mainen, Joseph, Cosam, Innocent, Esther, and Nkunya, Mayunga

Pharmaceutical Biology (Lisse, Netherlands) 2004. 42(4-5): 269-273

11. 44672 OI-LS-313; SCIFINDER-OI-1/5/2005

Synthesis and potent antimicrobial activity of some novel 4-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides

Oezden, Seckin, Karatas, Hacer, Yildiz, Sulhiye, and Goeker, Hakan

Archiv der Pharmazie (Weinheim, Germany) 2004. 337(10): 556-562

12. 44673 OI-LS-313; PUBMED-OI-1/11/2004

The past, present and future of antiviral drug discovery

Littler, E

IDrugs 2004. 7(12): 1104-12


13. 44674 OI-LS-313; SCIFINDER-OI-1/5/2005

Synthesis and microbiological activity of some substituted N-(2-hydroxy-4-nitrophenyl)benzamides and phenylacetamides as possible metabolites of antimicrobial active benzoxazoles

Oeren, Ilkay Yildiz, Aki-Sener, Esin, Ertas, Cengiz, Arpaci, Oezlem Temiz, Yalcin, Ismail, and Altanlar, Nurten

Turkish Journal of Chemistry 2004. 28(4): 441-449

14. 44675 OI-LS-313; PUBMED-OI-1/11/2004

Inhibitors of virus replication: recent developments and prospects

Magden, J, Kaariainen, L, and Ahola, T

Appl Microbiol Biotechnol 2004.


15. 44676 OI-LS-313; SCIFINDER-OI-1/5/2005

Synthesis and antifungal activity of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(4-substituted acyl piperazin-1-yl)-2-propanols

Liang, Shuang, Liu, Chao-mei, Zhu, Jie, He, Qiu-qin, Jiang, Yuan-ying, and Cao, Yong-bing

Journal of Medical Colleges of PLA 2004. 19(3): 142-145

16. 44677 OI-LS-313; SCIFINDER-OI-1/5/2005

Isatin-derived Antibacterial and Antifungal Compounds and their Transition Metal Complexes

Chohan, Zahid H, Pervez, Humayun, Rauf, A, Khan, Khalid M, and Supuran, Claudiu T

Journal of Enzyme Inhibition and Medicinal Chemistry 2004. 19(5): 417-423

17. 44678 OI-LS-313; SCIFINDER-OI-1/5/2005

In vitro anti-candidal activity of the essential oil of Illicium verum

Zhao, Junli, Luo, Zhicheng, Wu, Sanmao, Zhou, Xiaoli, Xue, Xiaoyun, Shi, Lei, and Li, Wenzhu

Zhonghua Pifuke Zazhi 2004. 37(8): 475-477

18. 44679 OI-LS-313; SCIFINDER-OI-1/5/2005

Synthesis and antifungal activity of cholesterol-hydrazone derivatives

Loncle, Celine, Brunel, Jean Michel, Vidal, Nicolas, Dherbomez, Michel, and Letourneux, Yves

European Journal of Medicinal Chemistry 2004. 39(12): 1067-1071

19. 44680 OI-LS-313; SCIFINDER-OI-1/5/2005

Preparation of 3-deoxyanthocyanidine compounds and their use as antimicrobial agents

George, Florian and Fellague, Toufik

PATENT: FR 2855172 ISSUE DATE: 20041126

APPLICATION: 2003-6088 PP: 60 pp.

ASSIGNEE: (Synth'e 163, Fr.

20. 44681 OI-LS-313; WOS-OI-1/2/2005

Albuferon (TM) - A novel therapeutic agent for hepatitis C: Results of a phase 1/2 study in treatment experienced subjects with chronic hepatitis C

Balan, V, Sulkowski, M, Nelson, D, Everson, G, Lambiase, L, Post, A, Redfield, R, Wiesner, R, Davis, G, Neumann, A, Recta, J, Moore, P, Osborn, B, Novello, L, Freimuth, W, and Subramanian, M

HEPATOLOGY 2004. 40(4): 280A-281A, 2


21. 44682 OI-LS-313; SCIFINDER-OI-1/5/2005

Diastereoselective Synthesis and Antifungal Activity of Glycosyl Isoxazolines

Mishra, Ram Chandra, Tewari, Neetu, Verma, Shyam Sunder, Tripathi, Rama Pati, Kumar, Manish, and Shukla, Praveen Kumar

Journal of Carbohydrate Chemistry 2004. 23(6 & 7): 353-374

22. 44683 OI-LS-313; WOS-OI-1/2/2005

Final results of ANRS HC02-RIBAVIC: A randomized controlled trial of pegylated-interferon alfa-2B plus ribavirin vs interferon alfa-2B plus ribavirin for the initial treatment of chronic hepatitis C in HIV co-infected

Pol, S, Carrat, F, Bani-Sadr, F, Rosenthal, E, Lunel, F, Morand, P, Salmon, D, Pialoux, G, Patrice, C, and Christian, P

HEPATOLOGY 2004. 40(4): 315A-1


23. 44684 OI-LS-313; WOS-OI-1/2/2005

Dynamics of HCV free-virion and immunecomplex during interferon therapy with and without ribavirin in genotype-1B chronic hepatitis C

Fujita, N, Kaito, M, Takeo, M, Sugimoto, R, Horiike, S, Tanaka, H, Konishi, M, Watanabe, S, and Adachi, Y

HEPATOLOGY 2004. 40(4): 319A-1


24. 44685 OI-LS-313; SCIFINDER-OI-1/5/2005

Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds

Cushion, Melanie T, Walzer, Peter D, Collins, Margaret S, Rebholz, Sandra, Vanden Eynde, Jean Jacques, Mayence, Annie, and Huang, Tien L

Antimicrobial Agents and Chemotherapy 2004. 48(11): 4209-4216

25. 44686 OI-LS-313; WOS-OI-1/2/2005

Molecular mechanism susceptibility profile of BILN-2061 to various hepatitis C virus genotypes and NS3-NS4A protease inhibitor mutation: D168A and D168V

Courcambeck, J, Perbost, R, Chabaud, P, Pepe, G, Bouzidi, M, Mabrouk, K, Sabatier, JM, and Halfon, P

HEPATOLOGY 2004. 40(4): 385A-1


26. 44687 OI-LS-313; WOS-OI-1/2/2005

In vitro resistance mutations against VX-950 and BILN 2061, two HCV protease inhibitor clinical candidates: Single-resistance, cross-resistance, and fitness

Lin, C, Rao, BG, Luong, YP, Fulghum, JR, Brennan, DL, Wei, YY, Frantz, JD, Lippke, J, Hsiao, HM, Ma, S, Lin, K, Maxwell, JP, Cottrell, KM, Gates, CA, Perni, RB, and Kwong, AD

HEPATOLOGY 2004. 40(4): 404A-1


27. 44688 OI-LS-313; WOS-OI-1/2/2005

High-throughput screening of anti-HCV drug candidates using an ELISA-based HCV replicon assay

Tan, H, Hong, J, Seiwert, S, and Blatt, LM

HEPATOLOGY 2004. 40(4): 407A-1


28. 44689 OI-LS-313; SCIFINDER-OI-1/5/2005

Preparation of 2,4-diaminoquinazoline, 2-amino-4-hydroxypteridine and 2,4-diaminopyrimidine ester derivatives as dihydrofolate reductase inhibitors

Boman, Arne, Lundstedt, Torbjorn, Andersson, Per, and Seifert, Elisabeth

PATENT: WO 2004020417 ISSUE DATE: 20040311

APPLICATION: 2003 PP: 41 pp.

ASSIGNEE: (Melacure Therapeutics AB, Swed. and Pett, Christopher Phineas

29. 44690 OI-LS-313; SCIFINDER-OI-1/5/2005

Discovery of Bicyclic Thymidine Analogues as Selective and High-Affinity Inhibitors of Mycobacterium tuberculosis Thymidine Monophosphate Kinase

Vanheusden, Veerle, Munier-Lehmann, Helene, Froeyen, Matheus, Busson, Roger, Rozenski, Jef, Herdewijn, Piet, and Van Calenbergh, Serge

Journal of Medicinal Chemistry 2004. 47(25): 6187-6194

30. 44691 OI-LS-313; SCIFINDER-OI-1/5/2005

Few amino acid positions in are associated with most of the rifampin resistance in Mycobacterium tuberculosis

Cummings, Michael P and Segal, Mark R

BMC Bioinformatics 2004. 5: No pp. given

31. 44692 OI-LS-313; SCIFINDER-OI-1/5/2005

<04 Article Title>

Metaferia, Belhu B and Bewley, Carole A

<10 Journal Title> 2004.(<24 Issue ID>): <25 Page(s)>

32. 44693 OI-LS-313; SCIFINDER-OI-1/5/2005

Mycobacterium tuberculosis mutants with disabled Rv3351c (NecB) and Rv3874 genes as vaccines, for producing diagnostic antibodies and for screening tuberculosis inhibitors

King, CHarold, Jacobs, William, and Okenu, Daniel

PATENT: WO 2004067718 ISSUE DATE: 20040812

APPLICATION: 2004 PP: 144 pp.

ASSIGNEE: (Emory University, USA

33. 44694 OI-LS-313; WOS-OI-1/2/2005

Selection and characterization of hepatitis C virus replicons resistant to potent NS5B polymerase inhibitors

Lu, LJ, Mo, HM, Pilot-Matias, T, Dekhtyar, T, Ng, T, Pithawalla, R, Masse, S, Pratt, J, Donner, P, Maring, C, and Molla, A

HEPATOLOGY 2004. 40(4): 694A-1


34. 44695 OI-LS-313; SCIFINDER-OI-1/5/2005

A mutant of Mycobacterium tuberculosis H37Rv that lacks expression of antigen 85A is attenuated in mice but retains vaccinogenic potential

Copenhaver, Robert H, Sepulveda, Eliud, Armitige, Lisa Y, Actor, Jeffrey K, Wanger, Audrey, Norris, Steven J, Hunter, Robert L, and Jagannath, Chinnaswamy

Infection and Immunity 2004. 72(12): 7084-7095

35. 44696 OI-LS-313; SCIFINDER-OI-1/5/2005

1,3,4-Thiadiazole Derivatives. Synthesis, Structure Elucidation, and Structure-Antituberculosis Activity Relationship Investigation

Oruc, Elcin E, Rollas, Sevim, Kandemirli, Fatma, Shvets, Nathaly, and Dimoglo, Anatholy S

Journal of Medicinal Chemistry 2004. 47(27): 6760-6767

36. 44697 OI-LS-313; WOS-OI-1/2/2005

Results of a phase I single-dose escalation study of the hepatitis C protease inhibitor VX950 in healthy volunteers

Chu, HM, McNair, L, and Purdy, S

HEPATOLOGY 2004. 40(4): 735A-1


37. 44698 OI-LS-313; SCIFINDER-OI-1/5/2005

Preparation of benzimidazolyl ureas and related compounds as gyrase inhibitors for treating bacterial infections

Charifson, Paul S, Deininger, David D, Grillot, Anne-Laure, Liao, Yusheng, Ronkin, Steven M, Stamos, Dean, Perola, Emanuele, Wang, Tiansheng, Letiran, Arnaud, and Drumm, Joseph

PATENT: US 2004235886 ISSUE DATE: 20041125

APPLICATION: 2004-46742 PP: 148 pp.


38. 44699 OI-LS-313; SCIFINDER-OI-1/5/2005

Inhibitors of mycobacterial serine/threonine protein kinases for the treatment of mycobacterial infections

Pato, Janos, Keri, Gyorgy, Orfi, Laszlo, Waczek, Frigyes, Horvath, Zoltan, Banhegyi, Peter, Szabadkai, Istavan, Marosfalvi, Jeno, Hegymegi-Barakonyi, Balint, Szekelyhidi, Zsolt, Greff, Zoltan, Choidas, Axel, Bacher, Gerald, Missio, Andrea, and Koul, Anil

PATENT: US 2004171603 ISSUE DATE: 20040902

APPLICATION: 2003-60231 PP: 51 pp., Cont.-in-part of Appl. No. PCT/EP03-03697.


39. 44700 OI-LS-313; WOS-OI-1/2/2005

Toxicogenomics in drug discovery: from preclinical studies to clinical trials

Yang, Y, Blomme, EAG, and Waring, JF



40. 44701 OI-LS-313; WOS-OI-1/2/2005

Interaction of shikimic acid with shikimate kinase

Pereira, JH, de Oliveira, JS, Canduri, F, Dias, MVB, Palma, MS, Basso, LA, de Azevedo, WF, and Santos, DS



41. 44702 OI-LS-313; WOS-OI-1/2/2005

Cell biology of Mycobacterium tuberculosis phagosome

Vergne, I, Chua, J, Singh, SB, and Deretic, V



42. 44703 OI-LS-313; WOS-OI-1/9/2005

Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates

Lenaerts, AJ, Chapman, PL, and Orme, IM

TUBERCULOSIS 2004. 84(6): 361-364, 4


43. 44704 OI-LS-313; SCIFINDER-OI-1/5/2005

A subinhibitory concentration of clarithromycin inhibits Mycobacterium avium biofilm formation

Carter, George, Young, Lowell S, and Bermudez, Luiz E

Antimicrobial Agents and Chemotherapy 2004. 48(12): 4907-4910

44. 44705 OI-LS-313; SCIFINDER-OI-1/5/2005

Heterocyclic compounds, specifically 3,6-disubstituted 3H-furo[2,3-d]pyrimidin-2-ones and 2,6-disubstituted furo[2,3-d]pyrimidines, for use as novel nucleoside analogs and antivirals in the treatment of viral infections, particularly cytomegalovirus

McGuigan, Christopher, Balzarini, Jan, and De Clercq, Erik

PATENT: WO 2004096813 ISSUE DATE: 20041111

APPLICATION: 2004 PP: 62 pp.

ASSIGNEE: (University College Cardiff Consultants Limited, UK and Rega Foundation)

45. 44706 OI-LS-313; WOS-OI-1/9/2005

Human cytomegalovirus encodes a highly specific RANTES decoy receptor

Wang, D, Bresnahan, W, and Shenk, T



46. 44707 OI-LS-313; SCIFINDER-OI-1/5/2005

Synthesis and antiviral activities of 1'-carbon-substituted 4'-thiothymidines

Haraguchi, Kazuhiro, Takahashi, Haruhiko, Tanaka, Hiromichi, Hayakawa, Hiroyuki, Ashida, Noriyuki, Nitanda, Takao, and Baba, Masanori

Bioorganic & Medicinal Chemistry 2004. 12(20): 5309-5316

47. 44708 OI-LS-313; WOS-OI-1/9/2005

Screening of antibacterial and antifungal activities of ten medicinal plants from Ghana

Hoffman, BR, DelasAlas, H, Blanco, K, Wiederhold, N, Lewis, RE, and Williams, L

PHARMACEUTICAL BIOLOGY 2004. 42(1): 13-17, 5


48. 44709 OI-LS-313; SCIFINDER-OI-1/5/2005

Suppression of hepatitis C virus replicon by TGF-b

Murata, Takayuki, Ohshima, Takayuki, Yamaji, Masashi, Hosaka, Masahiro, Miyanari, Yusuke, Hijikata, Makoto, and Shimotohno, Kunitada

Virology 2005. 331(2): 407-417

49. 44710 OI-LS-313; SCIFINDER-OI-1/5/2005

A strategy for obtaining near full-length HCV cDNA clones (assemblicons) by assembly PCR

Sheehy, P, Scallan, M, Kenny-Walsh, E, Shanahan, F, and Fanning, LJ

Journal of Virological Methods 2005. 123(2): 115-124

50. 44711 OI-LS-313; WOS-OI-1/9/2005

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Vanheusden, V, Munier-Lehmann, H, Froeyen, M, Busson, R, Rozenski, J, Herdewijn, P, and Van, Calenbergh S

JOURNAL OF MEDICINAL CHEMISTRY 2004. 47(25): 6187-6194, 8


51. 44712 OI-LS-313; WOS-OI-1/9/2005

Three-dimensional quantitative structure-activity and structure-selectivity relationships of dihydrofolate reductase inhibitors

Sutherland, JJ and Weaver, DF



52. 44713 OI-LS-313; WOS-OI-1/9/2005

Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability

Nassar, AEF, Kamel, AM, and Clarimont, C

DRUG DISCOVERY TODAY 2004. 9(23): 1020-1028, 9


53. 44714 OI-LS-313; WOS-OI-1/9/2005

Synthesis of trehalose-based compounds and their inhibitory activities against Mycobacterium smegmatis

Wang, J, Elchert, B, Hui, Y, Takemoto, JY, Bensaci, M, Wennergren, J, Chang, H, Rai, R, and Chang, CWT

BIOORGANIC & MEDICINAL CHEMISTRY 2004. 12(24): 6397-6413, 17


54. 44715 OI-LS-313; WOS-OI-1/9/2005

Crystallographic and NMR studies of antiinfective tricyclic guanidine alkaloids from the sponge Monanchora unguifera

Hua, HM, Peng, JN, Fronczek, FR, Kelly, M, and Hamann, MT

BIOORGANIC & MEDICINAL CHEMISTRY 2004. 12(24): 6461-6464, 4


55. 44716 OI-LS-313; WOS-OI-1/9/2005

Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues

Monga, V, Nayyar, A, Vaitilingam, B, Palde, PB, Jhamb, SS, Kaur, S, Singh, PP, and Jain, R

BIOORGANIC & MEDICINAL CHEMISTRY 2004. 12(24): 6465-6472, 8


56. 44717 OI-LS-313; WOS-OI-1/9/2005

Synthesis and study of antibacterial and antifungal activities of novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino]thiazoles

Kaplancikli, ZA, Turan-Zitouni, G, Revial, G, and Guven, K

ARCHIVES OF PHARMACAL RESEARCH 2004. 27(11): 1081-1085, 5


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