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1. 48565 OI-LS-343; PUBMED-OI-3/6/2006

Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis

Xu, ZQ, Pupek, K, Suling, WJ, Enache, L, and Flavin, MT

Bioorg Med Chem 2006.


2. 48566 OI-LS-343; PUBMED-OI-3/6/2006

Telbivudine: A Novel Nucleoside Analog for Chronic Hepatitis B (March)

Kim, JW, Park, SH, and Louie, SG

Ann Pharmacother 2006.


3. 48567 OI-LS-343; SCIFINDER-OI-2/27/2006

Effects of albendazole, fumagillin, and TNP-470 on microsporidial replication in vitro

Didier, Elizabeth S

Antimicrobial Agents and Chemotherapy 1997. 41(7): 1541-1546

4. 48568 OI-LS-343; PUBMED-OI-3/6/2006

The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis

Lemieux, MJ, Ference, C, Cherney, MM, Wang, M, Garen, C, and James, MN

J Struct Funct Genomics 2006.


5. 48569 OI-LS-343; SCIFINDER-OI-2/27/2006

Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects

Charvalos, Ekatherina, Tzatzarakis, Manolis N, Van Bambeke, Francoise, Tulkens, Paul M, Tsatsakis, Aristidis M, Tzanakakis, George N, and Mingeot-Leclercq, Marie-Paule

Journal of Antimicrobial Chemotherapy 2006. 57(2): 236-244

6. 48570 OI-LS-343; SCIFINDER-OI-2/27/2006

Preparation of arylamidine derivatives as antifungal agents

Hayashi, Kazuya, Kunitani, Kazuto, Uehara, Sayuri, and Morita, Teiichi

PATENT: WO 2006003881 ISSUE DATE: 20060112

APPLICATION: 2005 PP: 85 pp.

ASSIGNEE: (Toyama Chemical Co., Ltd. Japan

7. 48571 OI-LS-343; PUBMED-OI-3/6/2006

Potent Inhibition of Macrophage Responses to IFN-{gamma} by Live Virulent Mycobacterium tuberculosis Is Independent of Mature Mycobacterial Lipoproteins but Dependent on TLR2

Banaiee, N, Kincaid, EZ, Buchwald, U, Jacobs, WR Jr, and Ernst, JD

J Immunol 2006. 176(5): 3019-27


8. 48572 OI-LS-343; PUBMED-OI-3/6/2006

Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

Lin, TW, Melgar, MM, Kurth, D, Swamidass, SJ, Purdon, J, Tseng, T, Gago, G, Baldi, P, Gramajo, H, and Tsai, SC

Proc Natl Acad Sci U S A 2006.


9. 48573 OI-LS-343; PUBMED-OI-3/6/2006

Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase

Loregian, A and Coen, DM

Chem Biol 2006. 13(2): 191-200


10. 48574 OI-LS-343; PUBMED-OI-3/6/2006

Synthesis and antimicrobial activity of some new 1-alkyl-2-alkylthio-1,2,4-triazolobenzimidazole derivatives

Mohamed, BG, Hussein, MA, Abdel-Alim, AA, and Hashem, M

Arch Pharm Res 2006. 29(1): 26-33


11. 48575 OI-LS-343; SCIFINDER-OI-2/27/2006

Antibacterial and antifungal ferrocene incorporated dithiothione and dithioketone compounds

Chohan, Zahid H

Applied Organometallic Chemistry 2006. 20(2): 112-116

12. 48576 OI-LS-343; SCIFINDER-OI-2/27/2006

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048, and the discovery of posaconazole (Sch 56592)

Bennett, Frank, Saksena, Anil K, Lovey, Raymond G, Liu, Yi-Tsung, Patel, Naginbhai M, Pinto, Patrick, Pike, Russel, Jao, Edwin, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, Loebenberg, David, Wang, Haiyan, Cacciapuoti, Anthony, Moss, Eugene, Menzel, Fred, Hare, Roberta S, and Nomeir, Amin

Bioorganic & Medicinal Chemistry Letters 2006. 16(1): 186-190

13. 48577 OI-LS-343; SCIFINDER-OI-2/27/2006

Aerosolised antibiotics: a critical appraisal of their use

Hagerman, Jennifer K, Hancock, Kim E, and Klepser, Michael E

Expert Opinion on Drug Delivery 2006. 3(1): 71-86

14. 48578 OI-LS-343; SCIFINDER-OI-2/27/2006

Oxazolidinone derivatives as antimicrobials

Das Biswajit, Ahmed, Shahadat, Yadav, Ajay Singh, Ghosh, Soma, and Rattan, Ashok

PATENT: WO 2006018682 ISSUE DATE: 20060223


ASSIGNEE: (Ranbaxy Laboratories Limited, India

15. 48579 OI-LS-343; WOS-OI-2/26/2006

Genomic analysis of the Mycobacterium tuberculosis complex: applications to laboratory diagnosis and genotyping

Driscoll, JR, Parsons, LA, Salfinger, M, and Taber, HW



16. 48580 OI-LS-343; SCIFINDER-OI-2/27/2006

Methods of screening for inhibitors of m. tuberculosis, assays for use therein, and methods and compositions for treating of preventing m. tuberculosis infection

Derbyshire, Keith M and Kowalski, Joseph C

PATENT: WO 2006020898 ISSUE DATE: 20060223


ASSIGNEE: (Health Research, Inc. USA

17. 48581 OI-LS-343; SCIFINDER-OI-2/27/2006

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG

Anderton, Matthew C, Bhakta, Sanjib, Besra, Gurdyal S, Jeavons, Peter, Eltis, Lindsay D, and Sim, Edith

Molecular Microbiology 2006. 59(1): 181-192

18. 48582 OI-LS-343; SCIFINDER-OI-2/27/2006

High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis

Sullivan, Todd J, Truglio, James J, Boyne, Melissa E, Novichenok, Polina, Zhang, Xujie, Stratton, Christopher F, Li, Huei-Jiun, Kaur, Tejinder, Amin, Amol, Johnson, Francis, Slayden, Richard A, Kisker, Caroline, and Tonge, Peter J

ACS Chemical Biology 2006. 1(1): 43-53

19. 48583 OI-LS-343; SCIFINDER-OI-2/27/2006

Pyridinylamines and their preparations, pharmaceutical compositions and use for prophylaxis or treatment of various diseases

Eickhoff, Jan Eike, Hafenbradl, Doris, Schwab, Wilfried, Cotton, Matthew, Klebl, Bert Matthias, Zech, Birgit, Mueller, Stefan, Harris, John, Savic, Vladimir, Macritchie, Jackie, Sherborne, Brad, and Le, Joelle

PATENT: WO 2006010637 ISSUE DATE: 20060202

APPLICATION: 2005 PP: 177 pp.

ASSIGNEE: (Gpc Biotech AG, Germany

20. 48584 OI-LS-343; SCIFINDER-OI-2/27/2006

Concurrent antiviral and immunosuppressive activities of leflunomide in vivo

Chong, AS, Zeng, H, Knight, DA, Shen, J, Meister, GT, Williams, JW, and Waldman, WJ

American Journal of Transplantation 2006. 6(1): 69-75

21. 48585 OI-LS-343; SCIFINDER-OI-2/27/2006

Antiviral methods and compositions

Coen, Donald M and Loregian, Arianna

PATENT: WO 2006019955 ISSUE DATE: 20060223


ASSIGNEE: (President and Fellows of Harvard College, USA

22. 48586 OI-LS-343; SCIFINDER-OI-2/27/2006

Synthesis and screening of bicyclic carbohydrate-based compounds: A novel type of antivirals

Van Hoof, Steven, Ruttens, Bart, Hubrecht, Idzi, Smans, Gert, Blom, Petra, Sas, Benedikt, Van Hemel, Johan, Vandenkerckhove, Jan, and Van der Eycken, Johan

Bioorganic & Medicinal Chemistry Letters 2006. 16(6): 1495-1498

23. 48587 OI-LS-343; SCIFINDER-OI-2/27/2006

Agents with leukotriene B4-like antiviral (enveloped RNA) activities

Gosselin, Jean and Borgeat, Pierre

PATENT: US 2006025479 ISSUE DATE: 20060202

APPLICATION: 2004-11016 PP: 28 pp., Cont.-in-part of U.S. Ser. No. 683,882, abandoned.


24. 48588 OI-LS-343; SCIFINDER-OI-2/27/2006

Synthesis and Antiviral Evaluation of Cyclic and Acyclic 2-Methyl-3-hydroxy-4-pyridinone Nucleoside Derivatives

Barral, Karine, Balzarini, Jan, Neyts, Johan, De Clercq, Erik, Hider, Robert C, and Camplo, Michel

Journal of Medicinal Chemistry 2006. 49(1): 43-50

25. 48589 OI-LS-343; SCIFINDER-OI-2/27/2006

N-Substituted-sulfamoylbenzoic acid derivatives, particularly 4-[N-[4-(4-morpholino)phenyl]sulfamoyl]benzoic acid derivatives, method for preparing them, and antiviral pharmaceutical compositions comprising them, for treatment of hepatitis C virus infection

Kim, Jong Woo, Lee, Sang Wook, Lee, Geun Hyung, Han, Jae Jin, Park, Sang Jin, Park, Eul Yong, and Shin, Joong Chul

PATENT: WO 2006011719 ISSUE DATE: 20060202

APPLICATION: 2005 PP: 20 pp.

ASSIGNEE: (B & C Biopharm Co., Ltd. S. Korea

26. 48590 OI-LS-343; SCIFINDER-OI-2/27/2006

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery, SAR, Modeling, and Mutagenesis

Koch, Uwe, Attenni, Barbara, Malancona, Savina, Colarusso, Stefania, Conte, Immacolata, Di Filippo, Marcello, Harper, Steven, Pacini, Barbara, Giomini, Claudia, Thomas, Steven, Incitti, Ilario, Tomei, Licia, De Francesco, Raffaele, Altamura, Sergio, Matassa, Victor G, and Narjes, Frank

Journal of Medicinal Chemistry 2006. 49(5): 1693-1705

27. 48591 OI-LS-343; SCIFINDER-OI-2/27/2006

Preparation of peptide analogs as hepatitis C inhibitors

Bailey, Murray D, Bhardwaj, Punit, Ghiro, Elise, Goudreau, Nathalie, Halmos, Teddy, Llinas-Brunet, Montse, Poupart, Marc-Andre, and Rancourt, Jean

PATENT: WO 2006007708 ISSUE DATE: 20060126

APPLICATION: 2005 PP: 112 pp.

ASSIGNEE: (Boehringer Engelheim International GmbH, Germany and Boehringer Ingelheim Pharma Gmbh & Co KG)

28. 48592 OI-LS-343; SCIFINDER-OI-2/27/2006

Fused imidazole and thiazole derivatives as antiviral agents, their preparation, pharmaceutical compositions, and use for inhibiting hepatitis C virus polymerase

Conte, Immacolata, Hernando, Jose Ignacio Martin, Malancona, Savina, Ontoria Ontoria, Jesus Maria, and Stansfield, Ian

PATENT: WO 2006008556 ISSUE DATE: 20060126

APPLICATION: 2005 PP: 34 pp.

ASSIGNEE: (Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA, Italy

29. 48593 OI-LS-343; SCIFINDER-OI-2/27/2006

Heterocyclic antiviral compounds

Blake, James F, Fell, Jay Bradford, Fischer, John P, Hendricks, Robert Than, Robinson, John E, Spencer, Stacey Renee, and Stengel, Peter J

PATENT: US 2006040927 ISSUE DATE: 20060223

APPLICATION: 2005-12354 PP: 50 pp., which

ASSIGNEE: (Roche Palo Alto LLC, USA

30. 48594 OI-LS-343; SCIFINDER-OI-2/27/2006

Anti-viral nucleosides

Martin, Joseph Armstrong, Sarma, Keshab, and Smith, David Bernard

PATENT: US 2006040890 ISSUE DATE: 20060223

APPLICATION: 2005-11902 PP: 22 pp.

ASSIGNEE: (Roche Palo Alto LLC, USA

31. 48595 OI-LS-343; SCIFINDER-OI-2/27/2006

Cyanoacetic acid hydrazones of 3-(and 4-)acetylpyridine and some derived ring systems as potential antitumor and anti-HCV agents

El-Hawash, Soad AM, Abdel Wahab, Abeer E, and El-Demellawy, Maha A

Archiv der Pharmazie (Weinheim, Germany) 2006. 339(1): 14-23

32. 48596 OI-LS-343; SCIFINDER-OI-2/27/2006

Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidine and purine nucleoside analogs via condensation of the lactone to nucleosides as potential antiviral agents

Wang, Peiyuan, Stec, Wojciech, Clark, Jeremy, Chun, Byoung-Kwon, Shi, Junxing, and Du, Jinfa

PATENT: WO 2006012440 ISSUE DATE: 20060202

APPLICATION: 2005 PP: 34 pp.

ASSIGNEE: (Pharmasset, Inc. USA

33. 48597 OI-LS-343; SCIFINDER-OI-2/27/2006

Preparation of nucleoside aryl phosphoramidates for use as an inhibitor of hepatitis C virus NS5B polymerase, RNA-dependent RNA polymerase, RNA viral replication and treating RNA-dependent RNA viral infections

Maccoss, Malcolm and Olsen, David B

PATENT: WO 2006012078 ISSUE DATE: 20060202

APPLICATION: 2005 PP: 40 pp.

ASSIGNEE: (Merck & Co., Inc. USA

34. 48598 OI-LS-343; SCIFINDER-OI-2/27/2006

Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Roenn, Robert, Sabnis, Yogesh A, Gossas, Thomas, Aakerblom, Eva, Danielson, UHelena, Hallberg, Anders, and Johansson, Anja

Bioorganic & Medicinal Chemistry 2006. 14(2): 544-559

35. 48599 OI-LS-343; WOS-OI-2/26/2006

Fluoroquinolones: An important class of antibiotics against tuberculosis

De Souzaa, MVN, Vasconcelos, TRA, de Almeida, MV, and Cardoso, SH

CURRENT MEDICINAL CHEMISTRY 2006. 13(4): 455-463, 9


36. 48600 OI-LS-343; WOS-OI-2/26/2006

Novel yeast cell-based assay to screen for inhibitors of human cytomegalovirus protease in a high-throughput format

Cottier, V, Barberis, A, and Luthi, U



37. 48601 OI-LS-343; WOS-OI-3/5/2006

Structural characterization and antimicrobial activity of 2- 5-H/methyl-1H-benzimidazol-2-yl)-4-bromo/nitro-phenol ligands and their Fe(NO3)(3) complexes

Tavman, A, Agh-Atabay, NM, Neshat, A, Gucin, F, Dulger, B, and Haciu, D

TRANSITION METAL CHEMISTRY 2006. 31(2): 194-200, 7


38. 48602 OI-LS-343; WOS-OI-3/5/2006

Application and utilization of chemoinformatics tools in lead generation and optimization

Fotouhi, N, Gillespie, P, Goodnow, RA, So, SS, Han, Y, and Babiss, LE



39. 48603 OI-LS-343; WOS-OI-3/5/2006

Synthesis and biological evaluation of (E)-3-(nitrophenyl)-1-(pyrazin-2-yl)prop-2-en-1-ones

Opletalova, V, Pour, M, Kunes, J, Buchta, V, Silva, L, Kralova, K, Chlupacava, M, Meltrova, D, Peterka, M, and Poslednikova, M



40. 48604 OI-LS-343; WOS-OI-3/5/2006

Understanding the RNA-specificity of HCV RdRp: Implications for anti-HCV drug discovery

Kim, J and Chong, YH



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