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ONLINE DATABASE SEARCH - OI-LS-344 MEMO

1. 48623 OI-LS-344; PUBMED-OI-3/20/2006

A Mechanism of Virulence: Virulent Mycobacterium tuberculosis Strain H37Rv, but Not Attenuated H37Ra, Causes Significant Mitochondrial Inner Membrane Disruption in Macrophages Leading to Necrosis

Chen, M, Gan, H, and Remold, HG

J Immunol 2006. 176(6): 3707-3716


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16517739&dopt=abstract


2. 48624 OI-LS-344; PUBMED-OI-3/20/2006

Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease

Perni, RB, Almquist, SJ, Byrn, RA, Chandorkar, G, Chaturvedi, PR, Courtney, LF, Decker, CJ, Dinehart, K, Gates, CA, Harbeson, SL, Heiser, A, Kalkeri, G, Kolaczkowski, E, Lin, K, Luong, YP, Rao, BG, Taylor, WP, Thomson, JA, Tung, RD, Wei, Y, Kwong, AD, and Lin, C

Antimicrob Agents Chemother 2006. 50(3): 899-909


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16495249&dopt=abstract


3. 48625 OI-LS-344; PUBMED-OI-3/20/2006

Synthesis and Antiviral Evaluation of Alkoxyalkyl Derivatives of 9-(S)-(3-Hydroxy-2-phosphonomethoxypropyl)adenine against Cytomegalovirus and Orthopoxviruses

Beadle, JR, Wan, WB, Ciesla, SL, Keith, KA, Hartline, C, Kern, ER, and Hostetler, KY

J Med Chem 2006. 49(6): 2010-5


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16539388&dopt=abstract


4. 48626 OI-LS-344; EMBASE-OI-3/20/2006

Structure-activity relationship for nucleoside analogs as inhibitors and substrates of adenosine kinase from Mycobacterium tuberculosis. I. Modifications to the adenine moiety

Long, Mary C and Parker, William B

Biochemical Pharmacology 2006. In Press, Accepted Manuscript


HYPERLINK:

http://www.sciencedirect.com/science/article/B6T4P-4JFH6SW-3/2/822219f9a7c508206209c160b5286c06


5. 48627 OI-LS-344; EMBASE-OI-3/20/2006

Antiviral and antituberculous activity of Helichrysum melanacme constituents

Lall, N, Hussein, AA, and Meyer, JJM

Fitoterapia 2006. In Press, Corrected Proof


HYPERLINK:

http://www.sciencedirect.com/science/article/B6VSC-4JF97B2-1/2/de53525aafbb02316a052d4fbf3f89f9



6. 48628 OI-LS-344; PUBMED-OI-3/20/2006

Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-[3-(1-adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl] acetic acids, 2-[3-(1-adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl]propionic acids and related derivatives

Al-Deeb, OA, Al-Omar, MA, El-Brollosy, NR, Habib, EE, Ibrahim, TM, and El-Emam, AA

Arzneimittelforschung 2006. 56(1): 40-47

 

HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16478004&dopt=abstract


7. 48629 OI-LS-344; PUBMED-OI-3/20/2006

Present status and future prospects of chemotherapeutics for intractable infections due to Mycobacterium avium complex

Tomioka, H

Curr Drug Discov Technol 2004. 1(4): 255-68


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16472242&dopt=abstract


8. 48630 OI-LS-344; EMBASE-OI-3/20/2006

Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis

Xu, Ze-Qi, Pupek, Krzysztof, Suling, William J, Enache, Livia, and Flavin, Michael T

Bioorganic & Medicinal Chemistry 2006. In Press, Corrected Proof


HYPERLINK:

http://www.sciencedirect.com/science/article/B6TF8-4JCSK0M-2/2/86fbdefe94dcdb1e7253fea5416b270c


9. 48631 OI-LS-344; PUBMED-OI-3/20/2006

Influenza pandemics: past, present and future

Hsieh, YC, Wu, TZ, Liu, DP, Shao, PL, Chang, LY, Lu, CY, Lee, CY, Huang, FY, and Huang, LM

J Formos Med Assoc 2006. 105(1): 1-6


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16440064&dopt=abstract


10. 48632 OI-LS-344; PUBMED-OI-3/20/2006

Viral hepatitis treatment and beyond: a review of CROI 2005

Wilson, L and Gebo, K

Hopkins HIV Rep 2005. 17(3): 10-1, 16


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16419312&dopt=abstract



11. 48633 OI-LS-344; EMBASE-OI-3/20/2006

Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus

Case, Ryan J, Franzblau, Scott G, Wang, Yuehong, Cho, Sang Hyun, Soejarto, DDoel, and Pauli, Guido F

Journal of Ethnopharmacology 2006. In Press, Corrected Proof


HYPERLINK:

http://www.sciencedirect.com/science/article/B6T8D-4J2TSK8-2/2/fbbf2c6729ee7280bf41ea0001823d0a


12. 48634 OI-LS-344; EMBASE-OI-3/20/2006

Novel Inhibitors of Hepatitis C Virus RNA-dependent RNA Polymerases

Lee, Gary, Piper, Derek E, Wang, Zhulun, Anzola, John, Powers, Jay, Walker, Nigel, and Li, Yang

Journal of Molecular Biology 2006. 357(4): 1051-1057


HYPERLINK:

http://www.sciencedirect.com/science/article/B6WK7-4J554RY-2/2/affee7a6de984abb455f78ee2f1d17d6


13. 48635 OI-LS-344; WOS-OI-3/12/2006

Synthesis and antimicrobial evaluation of some 4-or 6-chloroisatin derivatives

Pandeya, SN, Raja, AS, and Nath, G

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY 2006. 45 (2): 494-499, 6


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235555800011


14. 48636 OI-LS-344; WOS-OI-3/12/2006

The robe of antiviral agents in the management of viral hepatitis

Mutimer, D

CLINICAL MEDICINE 2006. 6(1): 29-34, 6


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235642500008


15. 48637 OI-LS-344; WOS-OI-3/12/2006

Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents

Patole, J, Shingnapurkar, D, Padhye, S, and Ratledge, C

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2006. 16(6): 1514-1517, 4


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235492800012


16. 48638 OI-LS-344; WOS-OI-3/12/2006

Depeptidization efforts on P-3-P '(2) alpha-ketoamide inhibitors of HCVNS3-4A serine protease: Effect on HCV replicon activity

Bogen, SL, Ruan, S, Liu, R, Agrawal, S, Pichardo, J, Prongay, A, Baroudy, B, Saksena, AK, Girijavallabhan, V, and Njoroge, FG

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2006. 16(6): 1621-1627, 7


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235492800034



17. 48639 OI-LS-344; WOS-OI-3/12/2006

Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis snapshots of the enzyme in action

Wang, SS and Eisenberg, D

BIOCHEMISTRY 2006. 45(6): 1554-1561, 8


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235631400003


18. 48640 OI-LS-344; WOS-OI-3/12/2006

Genomics applied to drug candidate prioritization and for identification of novel therapeutically useful properties of existing drugs

Jarnagin, K, Roter, A, Tolley, A, Lee, M, and Natsoulis, CG

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2005. 229: U156-1


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235066600269


19. 48641 OI-LS-344; WOS-OI-3/12/2006

Development of new tuberculosis drug candidates

Laughon, BE

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2005. 229: U164-1


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235066600310


20. 48642 OI-LS-344; WOS-OI-3/12/2006

Novel inhibitors of InhA, the enoyl reductase from mycobacterium tuberculosis

Tonge, PJ, Sullivan, TJ, Novichenok, P, Truglio, JJ, Kisker, C, Johnson, F, and Slayden, RA

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2005. 229: U164-1


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235066600314


21. 48643 OI-LS-344; WOS-OI-3/12/2006

Cell wall of mycobacterium tuberculosis and drug discovery

Brennan, PJ

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2005. 229: U164-U165, 2


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235066600315


22. 48644 OI-LS-344; WOS-OI-3/12/2006

Synthesis and design of 2,4-diamino-6-substituted-pyrido[3,2-D]pyrimidines as dihydrofolate reductase inhibitors from opportunistic pathogens

Gangjee, A, Ye, ZQ, Kisliuk, RL, and Queener, SF

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2005. 229: U172-1


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235066600352


23. 48645 OI-LS-344; WOS-OI-3/12/2006

Developing novel inhibitors of the enoyl reductase from mycobacterium tuberculosis (INHA) : SAR studies of triclosan congeners

Sullivan, TJ, Novichenok, P, Truglio, JJ, Kisker, C, Johnson, F, Slayden, RA, and Tonge, PJ

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2005. 229: U176-1


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235066600376



24. 48646 OI-LS-344; WOS-OI-3/19/2006

Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis

Frenois, F, Baulard, AR, and Villeret, V

TUBERCULOSIS 2006. 86(2): 110-114, 5


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235740800002


25. 48647 OI-LS-344; WOS-OI-3/19/2006

Development of a toxicogenomics in vitro assay for the efficient characterization of compounds

Yang, Y, Abel, SJ, Ciurlionis, R, and Waring, JF

PHARMACOGENOMICS 2006. 7(2): 177-186, 10


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235752500010


26. 48648 OI-LS-344; WOS-OI-3/19/2006

Academia given a helping hand in drug development

Branca, MA

NATURE REVIEWS DRUG DISCOVERY 2006. 5(3): 177-1


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235836300003


27. 48649 OI-LS-344; WOS-OI-3/19/2006

Computer-assisted analysis of the interactions of macrocyclic inhibitors with wild type and mutant D168A hepatitis C virus NS3 serine protease

da Cunha, EFF, Ramalho, TC, Taft, CA, and de Alencastro, RB

LETTERS IN DRUG DESIGN & DISCOVERY 2006. 3(1): 17-28, 12


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235724000004


28. 48650 OI-LS-344; WOS-OI-3/19/2006

On the horizon: Promising investigational antiretroviral agents

McNicholl, IR and McNicholl, JJ

CURRENT PHARMACEUTICAL DESIGN 2006. 12(9): 1091-1103, 13


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235758400007


29. 48651 OI-LS-344; WOS-OI-3/19/2006

New methods for medicinal chemistry - Universal gene cloning and expression systems for production of marine bioactive metabolites

Dunlap, WC, Jaspars, M, Hranueli, D, Battershill, CN, Peric-Concha, N, Zucko, J, Wright, SH, and Long, PF

CURRENT MEDICINAL CHEMISTRY 2006. 13(6): 697-710, 14


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235756900008


30. 48652 OI-LS-344; WOS-OI-3/19/2006

Effectiveness of fluoroquinolones against Mycobacterium abscessus in vivo

Caballero, AR, Marquart, ME, O'Callaghan, RJ, Thibodeaux, BA, Johnston, KH, and Dajcs, JJ

CURRENT EYE RESEARCH 2006. 31(1): 23-29, 7


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000234819700003



31. 48653 OI-LS-344; WOS-OI-3/19/2006

rmlB and rmlC genes are essential fair growth with mycobacteria

Li, W, Xin, Y, McNeil, MR, and Ma, YF

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006. 342(1): 170-178, 9


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235793800023


32. 48654 OI-LS-344; WOS-OI-3/19/2006

SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells

Malcolm, BA, Liu, R, Lahser, F, Agrawal, S, Belanger, B, Butkiewicz, N, Chase, R, Gheyas, F, Hart, A, Hesk, D, Ingravallo, P, Jiang, C, Kong, R, Lu, J, Pichardo, J, Prongay, A, Skelton, A, Tong, X, Venkatraman, S, Xia, E, Girijavallabhan, V, and Njoroge, FG

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2006. 50(3): 1013-1020, 8


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235786300026


33. 48655 OI-LS-344; WOS-OI-3/19/2006

Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: Identification of a novel mutation in inhA

Leung, ETY, Ho, PL, Yuen, KY, Woo, WL, Lam, TH, Kao, RY, Seto, WH, and Yam, WC

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2006. 50(3): 1075-1078, 4


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000235786300034


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