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1. 48817 OI-LS-347; PUBMED-OI-5/2/2006

Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid

Argyrou, A, Vetting, MW, Aladegbami, B, and Blanchard, JS

Nat Struct Mol Biol 2006.


2. 48818 OI-LS-347; PUBMED-OI-5/2/2006

VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells

Lin, K, Perni, RB, Kwong, AD, and Lin, C

Antimicrob Agents Chemother 2006. 50(5): 1813-22


3. 48819 OI-LS-347; PUBMED-OI-5/2/2006

The potential of azole antifungals against latent/persistent tuberculosis

Ahmad, Z, Sharma, S, and Khuller, GK

FEMS Microbiol Lett 2006. 258(2): 200-3


4. 48820 OI-LS-347; PUBMED-OI-5/2/2006

Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells

von, Hahn T, Lindenbach, BD, Boullier, A, Quehenberger, O, Paulson, M, Rice, CM, and McKeating, JA

Hepatology 2006. 43(5): 932-942


5. 48821 OI-LS-347; PUBMED-OI-5/2/2006

Drugs for preventing tuberculosis in people at risk of multiple-drug-resistant pulmonary tuberculosis

Fraser, A, Paul, M, Attamna, A, and Leibovici, L

Cochrane Database Syst Rev 2006.(2): CD005435


6. 48822 OI-LS-347; SCIFINDER-OI-4/24/2006

Synthesis, antibacterial and antifungal activity of some new pyridazinone metal complexes

Soenmez, Mehmet, Berber, Ismet, and Akbas, Esvet

European Journal of Medicinal Chemistry 2006. 41(1): 101-105

7. 48823 OI-LS-347; PUBMED-OI-5/2/2006

Significant improvement of antifungal activity of polyene macrolides by bisalkylation of the mycosamine

Paquet, V and Carreira, EM

Org Lett 2006. 8(9): 1807-9


8. 48824 OI-LS-347; PUBMED-OI-5/2/2006

Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosis

Tufariello, JM, Mi, K, Xu, J, Manabe, YC, Kesavan, AK, Drumm, J, Tanaka, K, Jacobs, WR Jr, and Chan, J

Infect Immun 2006. 74(5): 2985-95


9. 48825 OI-LS-347; PUBMED-OI-5/2/2006

Protein Splicing of SufB Is Crucial for the Functionality of the Mycobacterium tuberculosis SUF Machinery

Huet, G, Castaing, JP, Fournier, D, Daffe, M, and Saves, I

J Bacteriol 2006. 188(9): 3412-4


10. 48826 OI-LS-347; PUBMED-OI-5/2/2006

Antiviral activity of cyclosaligenyl prodrugs of the nucleoside analogue bromovinyldeoxyuridine against herpes viruses

Meerbach, A, Meier, C, Sauerbrei, A, Meckel, HM, and Wutzler, P

Int J Antimicrob Agents 2006.


11. 48827 OI-LS-347; PUBMED-OI-5/2/2006

In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb

Rukayadi, Y, Yong, D, and Hwang, JK

J Antimicrob Chemother 2006.


12. 48828 OI-LS-347; SCIFINDER-OI-4/24/2006

Antimicrobial peptides enhance the candidacidal activity of antifungal drugs by promoting the efflux of ATP from Candida cells

Tanida Toyohiro, Okamoto Tetsuro, Ueta Eisaku, Yamamoto Tetsuya, and Osaki Tokio

The Journal of antimicrobial chemotherapy 2006. 57(1): 94-103.

13. 48829 OI-LS-347; PUBMED-OI-5/2/2006

Benzofuro[3,2-f][1]benzopyrans: A new class of antitubercular agents

Prado, S, Ledeit, H, Michel, S, Koch, M, Darbord, JC, Cole, ST, Tillequin, F, and Brodin, P

Bioorg Med Chem 2006.


14. 48830 OI-LS-347; PUBMED-OI-5/2/2006

Molecular Virology of Hepatitis C Virus (HCV): 2006 Update

Brass, V, Moradpour, D, and Blum, HE

Int J Med Sci 2006. 3(2): 29-34


15. 48831 OI-LS-347; SCIFINDER-OI-4/24/2006

Synthesis and evaluation of antimicrobial and anticonvulsant activities of some new 3-[2- (5-aryl-1,3,4-oxadiazol-2-yl/4-carbethoxymethylthiazol-2-yl) imino-4-thiazolidinon-5-ylidene]-5-substituted/nonsubstituted 1H-indole-2-ones and investigation of their structure-activity relationships

Altintas Handan, Ates Oznur, Uyde-Dogan B Sonmez, Alp F Ilkay, Kaleli Deniz, Ozdemir Osman, Birteksoz Seher, Otuk Gulten, Atana Dilek, and Uzun Meltem

Arzneimittel-Forschung 2006. 56(3): 239-48.

16. 48832 OI-LS-347; PUBMED-OI-5/2/2006

Recent advances in antiviral agents: antiviral drug discovery for hepatitis viruses

Tanikawa, K

Curr Pharm Des 2006. 12(11): 1371-7


17. 48833 OI-LS-347; SCIFINDER-OI-4/24/2006

Synthesis of New 3-(Substituted Phenacyl)-5-[3'-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones and their Antimicrobial Activity

Tuncbilek Meral and Altanlar Nurten

Archiv der Pharmazie 2006. 339(4): 213-6.

18. 48834 OI-LS-347; SCIFINDER-OI-4/24/2006

Antimicrobial principle from Aframomum longifolius

Tatsimo Simplice Joel Ndendoung, Tane Pierre, Melissa Jacob, Sondengam Beibam L, Okunji Christopher O, Schuster Brian M, Iwu Maurice M, and Khan Ikhlas A

Planta medica 2006. 72(2): 132-5.

19. 48835 OI-LS-347; PUBMED-OI-5/2/2006

Oligonucleotide-based antiviral strategies

Schubert, S and Kurreck, J

Handb Exp Pharmacol 2006.(173): 261-87


20. 48836 OI-LS-347; PUBMED-OI-5/2/2006

Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans

Navarro-Martinez, MD, Garcia-Canovas, F, and Rodriguez-Lopez, JN

J Antimicrob Chemother 2006.


21. 48837 OI-LS-347; PUBMED-OI-5/2/2006

Stepwise decrease in moxifloxacin susceptibility amongst clinical isolates of multidrug-resistant Mycobacterium tuberculosis: correlation with ofloxacin susceptibility

Kam, KM, Yip, CW, Cheung, TL, Tang, HS, Leung, OC, and Chan, MY

Microb Drug Resist 2006. 12(1): 7-11


22. 48838 OI-LS-347; WOS-OI-4/23/2006

Antimicrobials: targeting virulence genes necessary for intracellular multiplication

Liautard, JP, Jubier-Maurin, W, Boigegrain, RA, and Kohler, S

TRENDS IN MICROBIOLOGY 2006. 14(3): 109-113, 5


23. 48839 OI-LS-347; SCIFINDER-OI-4/24/2006

Antimicrobial and antimycobacterial activity of cyclostellettamine alkaloids from sponge Pachychalina sp

de Oliveira, Jaine HHL, Seleghim, Mirna HR, Timm, Christoph, Grube, Achim, Kock, Matthias, Nascimento, Gislene GF, Martins, Ana Claudia T, Silva, Elissa GO, de Souza, Ana Olivia, Minarini, Paulo RR, Galetti, Fabio CS, Silva, Celio L, Hajdu, Eduardo, and Berlinck, Roberto GS

Marine Drugs 2006. 4(1): 1-8

24. 48840 OI-LS-347; WOS-OI-4/23/2006

Tissue predilection sites and effect of dose on Mycobacterium avium subs. paratuberculosis organism recovery in a short-term bovine experimental oral infection model

Sweeney, RW, Uzonna, J, Whitlock, RH, Habecker, PL, Chilton, P, and Scott, P

RESEARCH IN VETERINARY SCIENCE 2006. 80(3): 253-259, 7


25. 48841 OI-LS-347; SCIFINDER-OI-4/24/2006

Synthesis and antiviral evaluation of novel 4'-hydroxymethyl branched apiosyl nucleosides

Kim Jin Woo and Hong Joon Hee

Nucleosides, nucleotides & nucleic acids 2006. 25(1): 109-17.

26. 48842 OI-LS-347; SCIFINDER-OI-4/24/2006

Use of [d-meala]3-[etval]4-cyclosporin for the treatment of hepatitis c infection and pharmaceutical composition comprising said [d-meala]3-[etval]4-cyclosporin

Scalfaro, Pietro, Dumont, Jean-Maurice, Vuagniaux, Gregoire, and Mauvernay, Rolland-Yves

PATENT: WO 2006038088 ISSUE DATE: 20060413

APPLICATION: 2005 PP: 34 pp.

ASSIGNEE: (Debiopharm SA, Switz.

27. 48843 OI-LS-347; SCIFINDER-OI-4/24/2006

Preparation of nucleoside analogs as antiviral agents for treating flaviviruses, pestiviruses and hepacivirus

Sommadossi, Jean-Pierre, Gosselin, Gilles, Storer, Richard, and Egan, James

PATENT: WO 2006037028 ISSUE DATE: 20060406

APPLICATION: 2005 PP: 73 pp.

ASSIGNEE: (Idenix (Cayman) Limited, Cayman I. and Centre National de la Recherche Scientifique)

28. 48844 OI-LS-347; SCIFINDER-OI-4/24/2006

Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication

Bogen, Stephane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Venkatraman, Srikanth, Pan, Weidong, Parekh, Tajel, Pike, Russel E, Ruan, Sumei, Liu, Rong, Baroudy, Bahige, Agrawal, Sony, Chase, Robert, Ingravallo, Paul, Pichardo, John, Prongay, Andrew, Brisson, Jean-Marc, Hsieh, Tony Y, Cheng, Kuo-Chi, Kemp, Scott J, Levy, Odile E, Lim-Wilby, Marguerita, Tamura, Susan Y, Saksena, Anil K, Girijavallabhan, Viyyoor, and Njoroge, FGeorge

Journal of Medicinal Chemistry 2006. 49(9): 2750-2757

29. 48845 OI-LS-347; SCIFINDER-OI-4/24/2006

Preparation of indoleacetamides as antivirals for treatment of hepatitis C infection

Colarusso, Stefania, Conte, Immacolata, Habermann, Joerg, Narjes, Frank, and Ponzi, Simona

PATENT: WO 2006029912 ISSUE DATE: 20060323

APPLICATION: 2005 PP: 58 pp.

ASSIGNEE: (Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A., Italy

30. 48846 OI-LS-347; SCIFINDER-OI-4/24/2006

Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidine and purine nucleoside analogs via condensation of the lactone to nucleosides as potential antiviral agents

Chun, Byoung-Kwon and Wang, Peiyuan

PATENT: WO 2006031725 ISSUE DATE: 20060323

APPLICATION: 2005 PP: 74 pp.

ASSIGNEE: (Pharmasset, Inc. USA

31. 48847 OI-LS-347; SCIFINDER-OI-4/24/2006

Synthesis and biological properties of 5'-methyl modified 3-deazaaristeromycin analogs

Ye, Wei, Liu, Chong, and Schneller, Stewart W

Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006 2006.: MEDI-373

32. 48848 OI-LS-347; SCIFINDER-OI-4/24/2006

Preparation of naphthalimide derivatives as antiviral agents

Carroll, Steve, Hernando, Jose Ignacio Martin, Malancona, Savina, Migliaccio, Giovanni, Narjes, Frank, Olsen, David, Ontoria Ontoria, Jesus Maria, Rowley, Michael, and Summa, Vincenzo

PATENT: WO 2006027628 ISSUE DATE: 20060316

APPLICATION: 2005 PP: 55 pp.

ASSIGNEE: (Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A., Italy and Merck & Co., Inc.

33. 48849 OI-LS-347; SCIFINDER-OI-4/24/2006

Imidazo[4,5-d]pyrimidines as antiviral agents and their methods of preparation, pharmaceutical compositions, and use for treatment of Flaviviridae and Picornaviridae, in particular HCV infections

Kim, Choung U, Neyts, Johan, Oare, David A, and Puerstinger, Gerhard

PATENT: US 2006052602 ISSUE DATE: 20060309

APPLICATION: 2005-59679 PP: 62 pp.

ASSIGNEE: (Gilead Sciences, Inc. USA

34. 48850 OI-LS-347; SCIFINDER-OI-4/24/2006

Preparation of pyrimidine nucleoside derivs. and use as antiviral agent against Hepatitis C Virus

Martin, Joseph Armstrong, Sarma, Keshab, and Smith, David Bernard

PATENT: US 2006040890 ISSUE DATE: 20060223

APPLICATION: 2005-11902 PP: 22 pp.

ASSIGNEE: (Roche Palo Alto LLC, USA

35. 48851 OI-LS-347; SCIFINDER-OI-4/24/2006

Preparation of indolecarboxylic acid derivatives as inhibitors of HCV replication

Hudyma, Thomas W, Zheng, Xiaofan, He, Feng, Ding, Min, Bergstrom, Carl P, Hewawasam, Piyasena, Martin, Scott W, and Gentles, Robert G

PATENT: WO 2006020082 ISSUE DATE: 20060223

APPLICATION: 2005 PP: 353 pp.

ASSIGNEE: (Bristol-Myers Squibb Company, USA

36. 48852 OI-LS-347; WOS-OI-4/23/2006

Antimicrobial activity of 1,2-Bis-[2-(5-R)-1H-benzimidazolyl]-1,2-ethanediols, 1,4-Bis-[2-(5-R)1H-benzimidazolyl]-1,2,3,4-butanetet aols and their Fe-III, Cu-II, and Ag-I complexes

Tavman, A, Birteksoz, S, and Otuk, G

FOLIA MICROBIOLOGICA 2005. 50(6): 467-472, 6


37. 48853 OI-LS-347; WOS-OI-4/23/2006

New antimycobacterial S-alkyllsothiosemicarbazones

Waisser, K, Heinisch, L, Slosarek, M, and Janota, J

FOLIA MICROBIOLOGICA 2005. 50(6): 479-481, 3


38. 48854 OI-LS-347; WOS-OI-4/23/2006

3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledion derivatives as new lead compounds for antibacterially active substances

Mahboobi, S, Eichhorn, E, Popp, A, Sellmer, A, Elz, S, and Mollmann, U



39. 48855 OI-LS-347; WOS-OI-4/23/2006

Synthesis and evaluation of new quinazolone derivatives of nalidixic acid as potential antibacterial and antifungal agents

Grover, G and Kini, SG



40. 48856 OI-LS-347; WOS-OI-4/23/2006

Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides

Sriram, D, Yogeeswari, P, and Devakaram, RV

BIOORGANIC & MEDICINAL CHEMISTRY 2006. 14(9): 3113-3118, 6


41. 48857 OI-LS-347; WOS-OI-4/23/2006

The membrane-active regions of the hepatitis C virus E1 and E2 envelope glycoproteins

Perez-Berna, AJ, Moreno, MR, Guillen, J, Bernabeu, A, and Villalain, J

BIOCHEMISTRY 2006. 45(11): 3755-3768, 14


42. 48858 OI-LS-347; WOS-OI-4/23/2006

Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant

Zhao, XB, Yu, H, Yu, SW, Wang, F, Sacchettini, JC, and Magliozzo, RS

BIOCHEMISTRY 2006. 45(13): 4131-4140, 10


43. 48859 OI-LS-347; WOS-OI-4/30/2006

Antiparasite and antimycobacterial activity of passifloricin analogues

Cardona, W, Quinones, W, Robledo, S, Velez, ID, Murga, J, Garcia-Fortanet, J, Carda, M, Cardona, D, and Echeverri, F

TETRAHEDRON 2006. 62(17): 4086-4092, 7


44. 48860 OI-LS-347; WOS-OI-4/30/2006

Structures of S-aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding

Kotaka, M, Dhaliwal, B, Ren, JS, Nichols, CE, Angell, R, Lockyer, M, Hawkins, AR, and Stammers, DK

PROTEIN SCIENCE 2006. 15(4): 774-784, 11


45. 48861 OI-LS-347; WOS-OI-4/30/2006

Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator

Fol, M, Chauhan, A, Nair, NK, Maloney, E, Moomey, M, Jagannath, C, Madiraju, MVVS, and Rajagopalan, M

MOLECULAR MICROBIOLOGY 2006. 60(3): 643-657, 15


46. 48862 OI-LS-347; WOS-OI-4/30/2006

Activity of novel non-amphipathic cationic antimicrobial peptides against Candida species

Burrows, LL, Stark, M, Chan, C, Glukhov, E, Sinnadurai, S, and Deber, CM



47. 48863 OI-LS-347; WOS-OI-4/30/2006

FR209602 and related compounds, novel antifungal lipopeptides from Coleophoma crateriformis no. 738 - II. In vitro and in vivo antifungal activity

Kanasaki, R, Abe, F, Furukawa, S, Yoshikawa, K, Fujie, A, Hino, M, Hashimoto, S, and Hori, Y

JOURNAL OF ANTIBIOTICS 2006. 59(3): 145-148, 4


48. 48864 OI-LS-347; WOS-OI-4/30/2006

FR220897 and FR220899, novel antifungal upopeptides from Coleophoma empetri no. 14573

Kanasaki, R, Abe, F, Kobayashi, M, Katsuoka, M, Hashimoto, M, Takase, S, Tsurumi, Y, Fujie, A, Hino, M, Hashimoto, S, and Hori, Y

JOURNAL OF ANTIBIOTICS 2006. 59(3): 149-157, 9


49. 48865 OI-LS-347; WOS-OI-4/30/2006

FR227673 and FR190293, novel antifungal lipopeptides from Chalara sp no. 22210 and Tolypociadium parasiticum no. 16616

Kanasaki, R, Kobayashi, M, Fujine, K, Sato, I, Hashimoto, M, Takase, S, Tsurumi, Y, Fujie, A, Hino, M, Hashimoto, S, and Hori, Y

JOURNAL OF ANTIBIOTICS 2006. 59(3): 158-167, 10


50. 48866 OI-LS-347; WOS-OI-4/30/2006

Simultaneous ethambutol & isoniazid resistance in clinical isolates of Mycobacterium tuberculosis

Gupta, P, Jadaun, GPS, Das, R, Gupta, UD, Srivastava, K, Chauhan, A, Sharma, VD, Chauhan, DS, and Katoch, VM



51. 48867 OI-LS-347; WOS-OI-4/30/2006

Back to the future: Where now for antituberculosis drugs?

Villarino, ME and Bliven, EE



52. 48868 OI-LS-347; WOS-OI-4/30/2006

Triaryl pyrazoline compound inhibits flavivirus RNA replication

Puig-Basagoiti, F, Tilgner, M, Forshey, BM, Philpott, SM, Espina, NG, Wentworth, DE, Goebel, SJ, Masters, PS, Falgout, B, Ren, P, Ferguson, DM, and Shi, PY



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