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1. 61036 OI-LS-376; WOS-OI-6/1/2007

Antiviral and Antimicrobial Profiles of Selected Isoquinoline Alkaloids From Fumaria and Corydalis Species

Orhan, I. et al.

Zeitschrift Fur Naturforschung C-a Journal of Biosciences 2007. 62(1-2): 19-26


2. 61037 OI-LS-376; EMBASE-OI-6/11/2007

Oxadiazole mannich bases: Synthesis and antimycobacterial activity

Ali, Mohamed Ashraf and Shaharyar, Mohammad

Bioorganic & Medicinal Chemistry Letters 2007. 17(12): 3314-3316


3. 61038 OI-LS-376; EMBASE-OI-6/11/2007

Synthesis of Symmetrical C- and Pseudo-symmetrical O-Linked Disaccharide Analogs for Arabinosyltransferase Inhibitory Activity in Mycobacterium tuberculosis

Pathak, Ashish K, Pathak, Vibha, Riordan, James R, Suling, William J, Gurcha, Sudagar S, Besra, Gurdyal S, and Reynolds, Robert C

Bioorganic & Medicinal Chemistry Letters 2007. In Press, Accepted Manuscript: 748


4. 61039 OI-LS-376; EMBASE-OI-6/11/2007

Ligand based virtual screening and biological evaluation of inhibitors of chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv

Agrawal, Himanshu, Kumar, Ashutosh, Bal, Naresh Chandra, Siddiqi, Mohammad Imran, and Arora, Ashish

Bioorganic & Medicinal Chemistry Letters 2007. 17(11): 3053-3058


5. 61040 OI-LS-376; EMBASE-OI-6/11/2007

Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis

Bonnac, Laurent, Gao, Guang-Yao, Chen, Liqiang, Felczak, Krzysztof, Bennett, Eric M, Xu, Hua, Kim, TaeSoo, Liu, Nina, Oh, HyeWon, Tonge, Peter J, and Pankiewicz, Krzysztof W

Bioorganic & Medicinal Chemistry Letters 2007. In Press, Corrected Proof: 727


6. 61041 OI-LS-376; WOS-OI-6/1/2007

Antimycobacterial Activity From Cyanobacterial Extracts and Phytochemical Screening of Methanol Extract of Hapalosiphon

Rao, M. et al.

Pharmaceutical Biology 2007. 45(2): 88-93


7. 61042 OI-LS-376; EMBASE-OI-6/11/2007

Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis

Dias, Marcio Vinicius Bertacine, Vasconcelos, Igor Bordin, Prado, Adriane Michele Xavier, Fadel, Valmir, Basso, Luiz Augusto, de Azevedo Jr, Walter Filgueira, and Santos, Diogenes Santiago

Journal of Structural Biology 2007. In Press, Uncorrected Proof: 205


8. 61043 OI-LS-376; EMBASE-OI-6/11/2007

Newer tetracycline derivatives: Synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase

Sriram, Dharmarajan, Yogeeswari, Perumal, Senchani, Geetha, and Banerjee, Debjani

Bioorganic & Medicinal Chemistry Letters 2007. 17(8): 2372-2375


9. 61044 OI-LS-376; WOS-OI-6/1/2007

Superinfection Exclusion in Cells Infected With Hepatitis C Virus

Tscherne, D. et al.

Journal of Virology 2007. 81(8): 3693-3703


10. 61045 OI-LS-376; WOS-OI-6/1/2007

New Natural Intergenotypic (2/5) Recombinant of Hepatitis C Virus

Legrand-Abravanel, F. et al.

Journal of Virology 2007. 81(8): 4357-4362


11. 61046 OI-LS-376; EMBASE-OI-6/11/2007

Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex

Kessl, Jacques J, Moskalev, Nikolai V, Gribble, Gordon W, Nasr, Mohamed, Meshnick, Steven R, and Trumpower, Bernard L

Biochimica et Biophysica Acta (BBA) - Bioenergetics 2007. 1767(4): 319-326


12. 61047 OI-LS-376; WOS-OI-6/1/2007

Antimicrobial Activity of Marine Sponges From Uraba Gulf, Colombian Caribbean Region

Galeano, E. and Martinez, A.

Journal De Mycologie Medicale 2007. 17(1): 21-24


13. 61048 OI-LS-376; EMBASE-OI-6/11/2007

Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide

Ozbek, Neslihan, Katircioglu, Hikmet, Karacan, Nurcan, and Baykal, Tulay

Bioorganic & Medicinal Chemistry 2007. 15(15): 5105-5109


14. 61049 OI-LS-376; EMBASE-OI-6/11/2007

Design, synthesis and molecular docking studies of novel triazole antifungal compounds

He, Qiu Qin, Li, Ke, Cao, Yong Bing, Dong, Huan Wen, Zhao, Li Hua, Liu, Chao Mei, and Sheng, Chun Quan

Chinese Chemical Letters 2007. 18(6): 663-666


15. 61050 OI-LS-376; EMBASE-OI-6/11/2007

Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics

Perni, Robert B, Chandorkar, Gurudatt, Cottrell, Kevin M, Gates, Cynthia A, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, Govinda, Schairer, Wayne C, Drie, John Van, and Wei, Yunyi

Bioorganic & Medicinal Chemistry Letters 2007. 17(12): 3406-3411


16. 61051 OI-LS-376; WOS-OI-6/1/2007

Update 2006/2007 - Treatment of Hepatitis


Drugs of the Future 2007. 32(2): 187-190


17. 61052 OI-LS-376; WOS-OI-6/1/2007

Drugs Under Development for the Treatment of Hepatitis

Mealy, N., Lupone, B., and Tell, M.

Drugs of the Future 2007. 32(2): 191-200


18. 61053 OI-LS-376; WOS-OI-6/1/2007

Drugs From Academia

Borman, S.

Chemical & Engineering News 2007. 85(16): 42-47


19. 61054 OI-LS-376; WOS-OI-6/1/2007

Relationship Between Mycobacterium Avium Subspecies Paratuberculosis, Il-1 Alpha, and Traf1 in Primary Bovine Monocyte-Derived Macrophages

Chiang, S. et al.

Veterinary Immunology and Immunopathology 2007. 116(3-4 ): 131-144


20. 61055 OI-LS-376; WOS-OI-6/1/2007

Predicting Hcv Treatment Duration With an Hcv Protease Inhibitor Co-Administered With Peg-Ifn/Rbv by Modeling Both Wild-Type Virus and Low Level Resistant Variant Dynamics

Khunvichai, A. et al.

Gastroenterology 2007. 132(4): A740-A741


21. 61056 OI-LS-376; WOS-OI-6/8/2007

Inhibition of Hepatitis C Virus Replication and Expression by Small Interfering Rna Targeting Host Cellular Genes

Xue, Q. et al.

Journal of Hepatology 2007. 46: S151


22. 61057 OI-LS-376; WOS-OI-6/8/2007

Ribavirin Acts as Hepatitis C Virus Mutagen on Nonstructural 5b Quasispecies in Vitro and During Antiviral Therapy

Hofmann, W. et al.

Journal of Hepatology 2007. 46: S164


23. 61058 OI-LS-376; WOS-OI-6/8/2007

Favorable Cross-Resistance Profile of Two 432 Novel Hepatitis C Virus Inhibitors, Sch-503034 and Hcv-766, and Enhanced Anti-Replicon Activity Mediated by the Combined Use of Both Compounds

Howe, A. et al.

Journal of Hepatology 2007. 46: S165


24. 61059 OI-LS-376; WOS-OI-6/8/2007

Combinations of 2'-Methylcytidine Analogs With Interferon Alpha-2b Lead to Synergistic Inhibition of Hepatitis C Virus Replication in a Replicon System

Bassit, L. et al.

Journal of Hepatology 2007. 46: S217


25. 61060 OI-LS-376; WOS-OI-6/8/2007

Ketoprofen Plus Peg-Ifn Alpha-2a and Ribavirin as a Triple Treatment for Genotype 1 (G1) Chronic Hepatitis C (Chc): Results of a Phase Ii Randomized Controlled Trial

Gramenzi, A. et al.

Journal of Hepatology 2007. 46: S231


26. 61061 OI-LS-376; WOS-OI-6/8/2007

R1479, a Novel Hepatitis C Polymerase Inhibitor: Lack of Pre-Existing Resistance Mutation Supports the Observed in Vivo High Barrier to Resistance

Le Pogam, S. et al.

Journal of Hepatology 2007. 46: S235


27. 61062 OI-LS-376; WOS-OI-6/8/2007

Novel Mode of Viral Decline During Telaprevir (Vx-950) and Peg-Ifn Combination Treatment Predicted by a New Combined Intracellular and Cellular Hepatitis C Viral Dynamics Model

Neumann, A. et al.

Journal of Hepatology 2007. 46: S236


28. 61063 OI-LS-376; WOS-OI-6/8/2007

The Influence of Nucleoside Free Haart on the Treatment of Chronic Hepatitis C With Pegylated Interferon/Ribavirin Combination Treatment

Rockstroh, J. et al.

Journal of Hepatology 2007. 46: S240


29. 61064 OI-LS-376; WOS-OI-6/8/2007

Combination of Two Hepatitis C Virus Inhibitors, Sch 503034 and Nm107, Provides Enhanced Antireplicon Activity and Suppresses Emergence of Resistant Replicons

Ralston, R. et al.

Journal of Hepatology 2007. 46: S298-S299


30. 61065 OI-LS-376; WOS-OI-6/8/2007

Purines Bearing Phenanthroline or Bipyridine Ligands and Their Ru-Ii Complexes in Position 8 as Model Compounds for Electrochemical Dna Labeling - Synthesis, Crystal Structure, Electrochemistry, Quantum Chemical Calculations, Cytostatic and Antiviral Activity

Vrabel, M. et al.

European Journal of Inorganic Chemistry 2007.(12): 1752-1769


31. 61066 OI-LS-376; WOS-OI-6/8/2007

Inhibitory Effects of Various Type Ifn on the Hcv Rna Replication of Hcv Replicon Cells

Fei, R. et al.

Journal of Hepatology 2007. 46: S168


32. 61067 OI-LS-376; WOS-OI-6/8/2007

Novel 4-Azido-2-Deoxy-Nucleoside Analogs Are Potent Inhibitors of Ns5b-Dependent Hcv Replication

Smith, D. et al.

Journal of Hepatology 2007. 46: S190


33. 61068 OI-LS-376; WOS-OI-6/8/2007

Ach-806: a Potent Inhibitor of Hcv Replication With a Novel Mechanism of Action

Huang, M. et al.

Journal of Hepatology 2007. 46: S221


34. 61069 OI-LS-376; WOS-OI-6/8/2007

Inhibition of Hcv Replication by Psi-6130: Mechanism of Biochemical Activation and Inhibition

Furman, P. et al.

Journal of Hepatology 2007. 46: S224


35. 61070 OI-LS-376; WOS-OI-6/8/2007

Effects of Telapravir (Vx950) in a Liver Biopsy Model of Hcv Infection: Genotype 1 Virions Are Inhibited in Vitro but Other Genotypes Are Less Responsive

Hibbert, L. and Foster, G.

Journal of Hepatology 2007. 46: S227


36. 61071 OI-LS-376; WOS-OI-6/8/2007

Inhibition of Hcv Replication by Psi-6130: Characterization of Activity in the Hcv Replicon System

Jiang, W. et al.

Journal of Hepatology 2007. 46: S228


37. 61072 OI-LS-376; WOS-OI-6/8/2007

R1479, a Novel Nucleoside Analog and Potent Inhibitor of Hcv Replication, Does Not Affect Ribavirin-Induced Hemolysis and Erythrocyte Fragility in Vitro

Jiang, W. et al.

Journal of Hepatology 2007. 46: S228


38. 61073 OI-LS-376; WOS-OI-6/8/2007

Nim811, a Cyclophilin Inhibitor, and Nm107, an Hcv Polymerase Inhibitor, Synergistically Inhibits Hcv Replication and Suppresses the Emergence of Resistance in Vitro

Lin, K. et al.

Journal of Hepatology 2007. 46: S230


39. 61074 OI-LS-376; WOS-OI-6/8/2007

Characterization of Pharmacokinetic/Pharmacodynamic Parameters for the Novel Hcv Polymerase Inhibitor a-848837

Molla, A. et al.

Journal of Hepatology 2007. 46: S234-S235


40. 61075 OI-LS-376; WOS-OI-6/8/2007

Short-Term Antiviral Activity and Safety of Ach-806 (Gs-9132), an Ns4a Antagonist, in Hcv Genotype I Infected Individuals

Pottage, J. et al.

Journal of Hepatology 2007. 46: S294-S295


41. 61076 OI-LS-376; WOS-OI-6/8/2007

The Reduction of Both Cyclophilin B and Hcv-Rna by the Cyclophilin Inhibitor Debio-025 Confirms the Importance of Cyclophilin B for Hcv Replication in Man

Gallay, R. et al.

Journal of Hepatology 2007. 46: S296


42. 61077 OI-LS-376; WOS-OI-6/8/2007

In Vitro Resistance Selection to the Hcv Nucleoside Polymerase Inhibitor R1479 and to the Protease Inhibitor Vx-950

Mccown, M. et al.

Journal of Hepatology 2007. 46: S297-S298


43. 61078 OI-LS-376; WOS-OI-6/8/2007

Hcv Antiviral Activity and Resistance Analysis in Chronically Infected Chimpanzees Treated With Ns3/4a Protease and Ns513 Polymerase Inhibitors

Olsen, D. et al.

Journal of Hepatology 2007. 46: S298


44. 61079 OI-LS-376; WOS-OI-6/8/2007

Il-2-Stimulated Natural Killer Cells Inhibit Hcv Replication: a Novel Concept to Prevent the Progression of Hcv Reinfection in Liver-Transplant Recipients Infected With Hcv.

Ohira, M. et al.

American Journal of Transplantation 2007. 7: 328


45. 61080 OI-LS-376; PUBMED-OI-6/11/2007

NAD(+)-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: Novel structure-function relationship and identification of a specific inhibitor

Srivastava, SK, Dube, D, Kukshal, V, Jha, AK, Hajela, K, and Ramachandran, R

Proteins 2007.


46. 61081 OI-LS-376; PUBMED-OI-6/11/2007

Phenotypic and structural analyses of HCV NS3 protease ARG155 variants: Sensitivity to telaprevir (VX-950) and interferon alpha

Zhou, Y, Muh, U, Hanzelka, BL, Bartels, DJ, Wei, Y, Rao, BG, Brennan, DL, Tigges, AM, Swenson, L, Kwong, AD, and Lin, C

J Biol Chem 2007.


47. 61082 OI-LS-376; PUBMED-OI-6/11/2007

Synthesis, characterisation and antimicrobial activity of copper(II) and manganese(II) complexes of coumarin-6,7-dioxyacetic acid (cdoaH(2)) and 4-methylcoumarin-6,7-dioxyacetic acid (4-MecdoaH(2)): X-ray crystal structures of [Cu(cdoa)(phen)(2)].8.8H(2)O and [Cu(4-Mecdoa)(phen)(2)].13H(2)O (phen=1,10-phenanthroline)

Creaven, BS, Egan, DA, Karcz, D, Kavanagh, K, McCann, M, Mahon, M, Noble, A, Thati, B, and Walsh, M

J Inorg Biochem 2007.


48. 61083 OI-LS-376; PUBMED-OI-6/11/2007

Investigating the Metabolic Capabilities of Mycobacterium tuberculosis H37Rv Using the in silico Strain iNJ661 and Proposing Alternative Drug Targets

Jamshidi, N and Palsson, BO

BMC Syst Biol 2007. 1(1): 26


49. 61084 OI-LS-376; PUBMED-OI-6/11/2007

Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates

Gangjee, A, Zeng, Y, Talreja, T, McGuire, JJ, Kisliuk, RL, and Queener, SF

J Med Chem 2007.


50. 61085 OI-LS-376; PUBMED-OI-6/11/2007

Hepatitis C virus: Virology, diagnosis and management of antiviral therapy

Chevaliez, S and Pawlotsky, JM

World J Gastroenterol 2007. 13(17): 2461-6


51. 61086 OI-LS-376; PUBMED-OI-6/11/2007

Life and death in bovine monocytes: The fate of Mycobacterium avium subsp. paratuberculosis

Woo, SR, Heintz, JA, Albrecht, R, Barletta, RG, and Czuprynski, CJ

Microb Pathog 2007.


52. 61087 OI-LS-376; PUBMED-OI-6/11/2007

Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis

Pathak, AK, Pathak, V, Seitz, L, Gurcha, SS, Besra, GS, Riordan, JM, and Reynolds, RC

Bioorg Med Chem 2007.


53. 61088 OI-LS-376; PUBMED-OI-6/11/2007

(2R,3S)-(+)- and (2S,3R)-(-)-Halofuginone lactate: Synthesis, absolute configuration, and activity against Cryptosporidium parvum

Linder, MR, Heckeroth, AR, Najdrowski, M, Daugschies, A, Schollmeyer, D, and Miculka, C

Bioorg Med Chem Lett 2007.


54. 61089 OI-LS-376; PUBMED-OI-6/11/2007

Substrate and inhibitor specificity of Mycobacterium avium dihydrofolate reductase

Bock, RA, Soulages, JL, and Barrow, WW

FEBS J 2007.


55. 61090 OI-LS-376; PUBMED-OI-6/11/2007

C-3 Alkyl/Arylalkyl-2,3-dideoxy Hex-2-enopyranosides as Antitubercular Agents: Synthesis, Biological Evaluation, and QSAR Study

Saquib, M, Gupta, MK, Sagar, R, Prabhakar, YS, Shaw, AK, Kumar, R, Maulik, PR, Gaikwad, AN, Sinha, S, Srivastava, AK, Chaturvedi, V, Srivastava, R, and Srivastava, BS

J Med Chem 2007.


56. 61091 OI-LS-376; PUBMED-OI-6/11/2007

Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase

Borowski, P, Lang, M, Haag, A, and Baier, A

Antivir Chem Chemother 2007. 18(2): 103-9


57. 61092 OI-LS-376; PUBMED-OI-6/11/2007

Oxime and Oxime Ether Derivatives of 1,4-Benzothiazine Related to Oxiconazole

Milanese, L, Giacche, N, Schiaffella, F, Vecchiarelli, A, Macchiarulo, A, and Fringuelli, R

ChemMedChem 2007.


58. 61093 OI-LS-376; PUBMED-OI-6/11/2007

Drug susceptibility testing of Mycobacterium tuberculosis complex using a high throughput, reproducible, absolute concentration method

van Klingeren, B, Dessens-Kroon, M, van der Laan, T, Kremer, K, and van Soolingen, D

J Clin Microbiol 2007.


59. 61094 OI-LS-376; PUBMED-OI-6/11/2007

A Mycobacterium marinum Zone of Inhibition Assay as a Method for Screening Potential Antimycobacterial Compounds from Marine Extracts

Barker, LP, Lien, BA, Brun, OS, Schaak, DD, McDonough, KA, and Chang, LC

Planta Med 2007.


60. 61095 OI-LS-376; PUBMED-OI-6/11/2007

Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria

Davis, CB, Hartnell, RD, Madge, PD, Owen, DJ, Thomson, RJ, Chong, AK, Coppel, RL, and Itzstein, MV

Carbohydr Res 2007.


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