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Other Viruses Citation List: March 14 - March 27, 2014

Hepatitis C Virus

1. Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors. Belema, M., O.D. Lopez, J.A. Bender, J.L. Romine, D.R. St Laurent, D.R. Langley, J.A. Lemm, D.R. O'Boyle, 2nd, J.H. Sun, C. Wang, R.A. Fridell, and N.A. Meanwell. Journal of Medicinal Chemistry, 2014. 57(5): p. 1643-1672; PMID[24621191].

[PubMed]. OV_0314-032714.


2. Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir. Belema, M., V.N. Nguyen, C. Bachand, D.H. Deon, J.T. Goodrich, C.A. James, R. Lavoie, O.D. Lopez, A. Martel, J.L. Romine, E.H. Ruediger, L.B. Snyder, D.R. Laurent, F. Yang, J. Zhu, H.S. Wong, D.R. Langley, S.P. Adams, G.H. Cantor, A. Chimalakonda, A. Fura, B.M. Johnson, J.O. Knipe, D.D. Parker, K.S. Santone, R.A. Fridell, J.A. Lemm, D.R. O'Boyle, 2nd, R.J. Colonno, M. Gao, N.A. Meanwell, and L.G. Hamann. Journal of Medicinal Chemistry, 2014. 57(5): p. 2013-2032; PMID[24521299].

[PubMed]. OV_0314-032714.


3. Up-regulation of the ATP-binding Cassette Transporter A1 Inhibits Hepatitis C Virus Infection. Bocchetta, S., P. Maillard, M. Yamamoto, C. Gondeau, F. Douam, S. Lebreton, S. Lagaye, S. Pol, F. Helle, W. Plengpanich, M. Guerin, M. Bourgine, M.L. Michel, D. Lavillette, P. Roingeard, W. le Goff, and A. Budkowska. Plos One, 2014. 9(3): p. e92140; PMID[24646941].

[PubMed]. OV_0314-032714.


4. Design and Synthesis of Imidazo[1,2-α][1,8]naphthyridine Derivatives as anti-HCV Agents via Direct C-H Arylation. Huang, S., J. Qing, S. Wang, H. Wang, L. Zhang, and Y. Tang. Organic & Biomolecular Chemistry, 2014. 12(15): p. 2344-2348; PMID[24595428].

[PubMed]. OV_0314-032714.


5. Molecular Dynamics Simulations and Structure-based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. Hucke, O., R. Coulombe, P. Bonneau, M. Bertrand-Laperle, C. Brochu, J. Gillard, M.A. Joly, S. Landry, O. Lepage, M. Llinas-Brunet, M. Pesant, M. Poirier, M. Poirier, G. McKercher, M. Marquis, G. Kukolj, P.L. Beaulieu, and T.A. Stammers. Journal of Medicinal Chemistry, 2014. 57(5): p. 1932-1943; PMID[23773186].

[PubMed]. OV_0314-032714.


6. Chemical Genetics-based Discovery of Indole Derivatives as HCV NS5B Polymerase Inhibitors. Jin, G., S. Lee, M. Choi, S. Son, G.W. Kim, J.W. Oh, C. Lee, and K. Lee. European Journal of Medicinal Chemistry, 2014. 75: p. 413-425; PMID[24561671].

[PubMed]. OV_0314-032714.


7. Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives. Kakarla, R., J. Liu, D. Naduthambi, W. Chang, R.T. Mosley, D. Bao, H.M. Steuer, M. Keilman, S. Bansal, A.M. Lam, W. Seibel, S. Neilson, P.A. Furman, and M.J. Sofia. Journal of Medicinal Chemistry, 2014. 57(5): p. 2136-2160; PMID[24476391].

[PubMed]. OV_0314-032714.


8. Novel Spiroketal Pyrrolidine GSK2336805 Potently Inhibits Key Hepatitis C Virus Genotype 1b Mutants: From Lead to Clinical Compound. Kazmierski, W.M., A. Maynard, M. Duan, S. Baskaran, J. Botyanszki, R. Crosby, S. Dickerson, M. Tallant, R. Grimes, R. Hamatake, M. Leivers, C.D. Roberts, and J. Walker. Journal of Medicinal Chemistry, 2014. 57(5): p. 2058-2073; PMID[24568313].

[PubMed]. OV_0314-032714.


9. Discovery of Selective Small Molecule Type III Phosphatidylinositol 4-Kinase Alpha (PI4kIIIα) Inhibitors as Anti Hepatitis C (HCV) Agents. Leivers, A.L., M. Tallant, J.B. Shotwell, S. Dickerson, M.R. Leivers, O.B. McDonald, J. Gobel, K.L. Creech, S.L. Strum, A. Mathis, S. Rogers, C.B. Moore, and J. Botyanszki. Journal of Medicinal Chemistry, 2014. 57(5): p. 2091-2106; PMID[23944386].

[PubMed]. OV_0314-032714.


10. Hepatitis C Virus NS5A Inhibitors and Drug Resistance Mutations. Nakamoto, S., T. Kanda, S. Wu, H. Shirasawa, and O. Yokosuka. World Journal of Gastroenterology, 2014. 20(11): p. 2902-2912; PMID[24659881].

[PubMed]. OV_0314-032714.


11. Synthesis of New 1,2,3-Triazol-4-yl-quinazoline nucleoside and Acyclonucleoside Analogues. Ouahrouch, A., M. Taourirte, J.W. Engels, S. Benjelloun, and H.B. Lazrek. Molecules, 2014. 19(3): p. 3638-3653; PMID[24662079].

[PubMed]. OV_0314-032714.


12. Highly Potent HCV NS4B Inhibitors with Activity against Multiple Genotypes. Phillips, B., R. Cai, W. Delaney, Z. Du, M. Ji, H. Jin, J. Lee, J. Li, A. Niedziela-Majka, M. Mish, H.J. Pyun, J. Saugier, N. Tirunagari, J. Wang, H. Yang, Q. Wu, C. Sheng, and C. Zonte. Journal of Medicinal Chemistry, 2014. 57(5): p. 2161-2166; PMID[24512292].

[PubMed]. OV_0314-032714.


13. The Discovery of Asunaprevir (BMS-650032), an Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. Scola, P.M., L.Q. Sun, A.X. Wang, J. Chen, N. Sin, B.L. Venables, S.Y. Sit, Y. Chen, A. Cocuzza, D.M. Bilder, S.V. D'Andrea, B. Zheng, P. Hewawasam, Y. Tu, J. Friborg, P. Falk, D. Hernandez, S. Levine, C. Chen, F. Yu, A.K. Sheaffer, G. Zhai, D. Barry, J.O. Knipe, Y.H. Han, R. Schartman, M. Donoso, K. Mosure, M.W. Sinz, T. Zvyaga, A.C. Good, R. Rajamani, K. Kish, J. Tredup, H.E. Klei, Q. Gao, L. Mueller, R.J. Colonno, D.M. Grasela, S.P. Adams, J. Loy, P.C. Levesque, H. Sun, H. Shi, L. Sun, W. Warner, D. Li, J. Zhu, N.A. Meanwell, and F. McPhee. Journal of Medicinal Chemistry, 2014. 57(5): p. 1730-1752; PMID[24564672].

[PubMed]. OV_0314-032714.


14. Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. Scola, P.M., A.X. Wang, A.C. Good, L.Q. Sun, K.D. Combrink, J.A. Campbell, J. Chen, Y. Tu, N. Sin, B.L. Venables, S.Y. Sit, Y. Chen, A. Cocuzza, D.M. Bilder, S. D'Andrea, B. Zheng, P. Hewawasam, M. Ding, J. Thuring, J. Li, D. Hernandez, F. Yu, P. Falk, G. Zhai, A.K. Sheaffer, C. Chen, M.S. Lee, D. Barry, J.O. Knipe, W. Li, Y.H. Han, S. Jenkins, C. Gesenberg, Q. Gao, M.W. Sinz, K.S. Santone, T. Zvyaga, R. Rajamani, H.E. Klei, R.J. Colonno, D.M. Grasela, E. Hughes, C. Chien, S. Adams, P.C. Levesque, D. Li, J. Zhu, N.A. Meanwell, and F. McPhee. Journal of Medicinal Chemistry, 2014. 57(5): p. 1708-1729; PMID[24555570].

[PubMed]. OV_0314-032714.


15. Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase. Talamas, F.X., S.C. Abbot, S. Anand, K.A. Brameld, D.S. Carter, J. Chen, D. Davis, J. de Vicente, A.D. Fung, L. Gong, S.F. Harris, P. Inbar, S.S. Labadie, E.K. Lee, R. Lemoine, S. Le Pogam, V. Leveque, J. Li, J. McIntosh, I. Najera, J. Park, A. Railkar, S. Rajyaguru, M. Sangi, R.C. Schoenfeld, L.R. Staben, Y. Tan, J.P. Taygerly, A.G. Villasenor, and P.E. Weller. Journal of Medicinal Chemistry, 2014. 57(5): p. 1914-1931; PMID[24195700].

[PubMed]. OV_0314-032714.


16. Discovery and Structure-Activity Relationships Study of Novel Thieno[2,3-b]pyridine Analogues as Hepatitis C Virus Inhibitors. Wang, N.Y., W.Q. Zuo, Y. Xu, C. Gao, X.X. Zeng, L.D. Zhang, X.Y. You, C.T. Peng, Y. Shen, S.Y. Yang, Y.Q. Wei, and L.T. Yu. Bioorganic & Medicinal Chemistry Letters, 2014. 24(6): p. 1581-1588; PMID[24529869].

[PubMed]. OV_0314-032714.

Human Cytomegalovirus

17. Sinugyrosanolide A, an Unprecedented C-4 Norcembranoid, from the Formosan Soft Coral Sinularia gyrosa. Cheng, S.Y., N.L. Shih, C.T. Chuang, S.F. Chiou, C.N. Yang, S.K. Wang, and C.Y. Duh. Bioorganic & Medicinal Chemistry Letters, 2014. 24(6): p. 1562-1564; PMID[24529868].

[PubMed]. OV_0314-032714.

Citations from the ISI Web of Knowledge Listings for O.V.

18. Modulation of PI3K-LXR alpha-Dependent Lipogenesis Mediated by Oxidative/Nitrosative Stress Contributes to Inhibition of HCV Replication by Quercetin. Pisonero-Vaquero, S., M.V. Garcia-Mediavilla, F. Jorquera, P.L. Majano, M. Benet, R. Jover, J. Gonzalez-Gallego, and S. Sanchez-Campos. Laboratory Investigation, 2014. 94(3): p. 262-274; ISI[000332091200002].

[WOS]. OV_0314-032714.


19. Kaempferol Derivatives as Antiviral Drugs against the 3a Channel Protein of Coronavirus. Schwarz, S., D. Sauter, K. Wang, R.H. Zhang, B. Sun, A. Karioti, A.R. Bilia, T. Efferth, and W. Schwarz. Planta Medica, 2014. 80(2-3): p. 177-182; ISI[000331441100010].

[WOS]. OV_0314-032714.


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