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1. 57888 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Antiviral cyclic D, L-a-peptides: Targeting a general biochemical pathway in virus infections

Horne, WSeth, Wiethoff, Christopher M, Cui, Chunli, Wilcoxen, Keith M, Amorin, Manuel, Ghadiri, MReza, and Nemerow, Glen R

Bioorganic & Medicinal Chemistry 2005. 13(17): 5145-5153

2. 57889 DMID-LS-103; WOS-DMID-10/11/2005 ; DMID-LSLOAD

Development of a Homogeneous Screening Assay for Automated Detection of Antiviral Agents Active Against Severe Acute Respiratory Syndrome-Associated Coronavirus

Ivens, T. et al.

Journal of Virological Methods 2005. 129(1): 56-63


3. 57890 DMID-LS-103; WOS-DMID-10/11/2005 ; DMID-LSLOAD

Antisense Phosphorothioate Oligonucleotide Inhibition of Hepatitis C Virus Genotype 4 Replication in Hepg2 Cells

El Awady, M.

Journal of Biotechnology 2005. 118: S79


4. 57891 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Broad-spectrum inhibitor of viruses in the Flaviviridae family

Ojwang, JO, Ali, S, Smee, DF, Morrey, JD, Shimasaki, CD, and Sidwell, RW

Antiviral Res 2005.


5. 57892 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern

Bright, RA, Medina, MJ, Xu, X, Perez-Oronoz, G, Wallis, TR, Davis, XM, Povinelli, L, Cox, NJ, and Klimov, AI

Lancet 2005. 366(9492): 1175-81


6. 57893 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Avian influenza A (H5N1) infection in humans

Beigel, JH, Farrar, J, Han, AM, Hayden, FG, Hyer, R, de, Jong MD, Lochindarat, S, Nguyen, TK, Nguyen, TH, Tran, TH, Nicoll, A, Touch, S, and Yuen, KY

N Engl J Med 2005. 353(13): 1374-85


7. 57894 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Neuraminidase inhibitors for influenza

Moscona, A

N Engl J Med 2005. 353(13): 1363-73


8. 57895 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Synthesis and Structure-Activity Relationship of the First Nonpeptidergic Inverse Agonists for the Human Cytomegalovirus Encoded Chemokine Receptor US28

Hulshof, JW, Casarosa, P, Menge, WM, Kuusisto, LM, van, der Goot H, Smit, MJ, de, Esch IJ, and Leurs, R

J Med Chem 2005. 48(20): 6461-71


9. 57896 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Antiviral random sequence oligonucleotides targeting viral families

Vaillant, Andrew and Juteau, Jean-Marc

PATENT: US 2005196382 ISSUE DATE: 20050908

APPLICATION: 2004-52308 PP: 100 pp., Cont.-in-part of U.S. Ser. No. 661,402.

ASSIGNEE: (Replicor, Inc. Can.

10. 57897 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Synthesis and Structure-Activity Relationships of Novel Anti-hepatitis C Agents: N(3),5'-Cyclo-4-(beta-d-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one Derivatives

Wang, P, Du, J, Rachakonda, S, Chun, BK, Tharnish, PM, Stuyver, LJ, Otto, MJ, Schinazi, RF, and Watanabe, KA

J Med Chem 2005. 48(20): 6454-60


11. 57898 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Simple but Highly Effective Three-Dimensional Chemical-Feature-Based Pharmacophore Model for Diketo Acid Derivatives as Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors

Di Santo, R, Fermeglia, M, Ferrone, M, Paneni, MS, Costi, R, Artico, M, Roux, A, Gabriele, M, Tardif, KD, Siddiqui, A, and Pricl, S

J Med Chem 2005. 48(20): 6304-6314


12. 57899 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease

Chen, KX, Njoroge, FG, Pichardo, J, Prongay, A, Butkiewicz, N, Yao, N, Madison, V, and Girijavallabhan, V

J Med Chem 2005. 48(20): 6229-35


13. 57900 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks

Casey, J, Cote, PJ, Toshkov, IA, Chu, CK, Gerin, JL, Hornbuckle, WE, Tennant, BC, and Korba, BE

Antimicrob Agents Chemother 2005. 49(10): 4396-9


14. 57901 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Inhibition of hepatitis C virus replication by antimonial compounds

Hwang, DR, Lin, RK, Leu, GZ, Lin, TY, Lien, TW, Yu, MC, Yeh, CT, and Hsu, JT

Antimicrob Agents Chemother 2005. 49(10): 4197-202


15. 57902 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility

Yen, HL, Herlocher, LM, Hoffmann, E, Matrosovich, MN, Monto, AS, Webster, RG, and Govorkova, EA

Antimicrob Agents Chemother 2005. 49(10): 4075-84


16. 57903 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Preparation of nucleosides as prodrugs and antiviral agents

Roberts, Christopher D, Keicher, Jesse D, and Dyatkina, Natalia B

PATENT: US 20050215511 ISSUE DATE: 20050929

APPLICATION: 2004-53973 PP: 58 pp., Cont.-in-part of U.S. Ser. No. 861,311.

ASSIGNEE: (Genelabs Technologies, Inc. USA

17. 57904 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Methods for preparing 7-(2'-substituted-b-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives as antiviral agents

Roberts, Christopher D, Keicher, Jesse D, and Dyatkina, Natalia B

PATENT: US 20050215510 ISSUE DATE: 20050929

APPLICATION: 2004-53137 PP: 28 pp., Cont.-in-part of U.S. Ser. No. 861,311.

ASSIGNEE: (Genelabs Technologies, Inc. USA

18. 57905 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge

Yang, G, Pevear, DC, Davies, MH, Collett, MS, Bailey, T, Rippen, S, Barone, L, Burns, C, Rhodes, G, Tohan, S, Huggins, JW, Baker, RO, Buller, RL, Touchette, E, Waller, K, Schriewer, J, Neyts, J, DeClercq, E, Jones, K, Hruby, D, and Jordan, R

J Virol 2005. 79(20): 13139-49


19. 57906 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Use of heterogeneous nuclear ribonucleoprotein K to inhibit the replication of hepatitis viruses B and C by binding to cis-regulatory elements

Poh, Lisa Ng Fong and Ren, Ee Chee

PATENT: WO 2005059138 ISSUE DATE: 20050630

APPLICATION: 2004 PP: 82 pp.

ASSIGNEE: (Agency for Science, Technology and Research Singapore

20. 57907 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Binding-site characterization and resistance to a class of non-nucleoside inhibitors of the HCV NS5B polymerase

Kukolj, G, McGibbon, GA, McKercher, G, Marquis, M, Lefebvre, S, Thauvette, L, Gauthier, J, Goulet, S, Poupart, MA, and Beaulieu, PL

J Biol Chem 2005.


21. 57908 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Human cytomegalovirus-inhibitory flavonoids: Studies on antiviral activity and mechanism of action

Evers, DL, Chao, CF, Wang, X, Zhang, Z, Huong, SM, and Huang, ES

Antiviral Res 2005.


22. 57909 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Ectromelia virus: the causative agent of mousepox

Esteban, DJ and Buller, RM

J Gen Virol 2005. 86(Pt 10): 2645-59


23. 57910 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Preparation of phosphonated isoxazolidinyl nucleoside analogs with antiviral activity

Chiacchio, Ugo, Corsaro, Antonino, Iannazzo, Daniela, Macchi, Beatrice, Mastino, Antonio, Piperno, Anna, Rescifina, Antonio, Romeo, Giovanni, and Romeo, Roberto

PATENT: WO 2005082896 ISSUE DATE: 20050909

APPLICATION: 2005 PP: 29 pp.

ASSIGNEE: (Universita' Degli Studi di Catania, Italy and Universita' Degli Studi di Messina)

24. 57911 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

High-Throughput Cell-Based Screening for Hepatitis C Virus NS3/4A Protease Inhibitors

Lee, JC, Yu, MC, Lien, TW, Chang, CF, and Hsu, JT

Assay Drug Dev Technol 2005. 3(4): 385-392


25. 57912 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

New approaches and therapeutic modalities for the treatment of patients with chronic hepatitis C

Cornberg, M and Manns, MP

Ann Hepatol 2005. 4(3): 144-50


26. 57913 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as Non-Nucleoside Inhibitors of Human Cytomegalovirus and Related Herpesvirus Polymerases

Schnute, Mark E, Cudahy, Michele M, Brideau, Roger J, Homa, Fred L, Hopkins, Todd A, Knechtel, Mary L, Oien, Nancee L, Pitts, Thomas W, Poorman, Roger A, Wathen, Michael W, and Wieber, Janet L

Journal of Medicinal Chemistry 2005. 48(18): 5794-5804

27. 57914 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Both antigen optimization and lysosomal targeting are required for enhanced anti-tumour protective immunity in a human papillomavirus E7-expressing animal tumour model

Kim, MS and Sin, JI

Immunology 2005. 116(2): 255-66


28. 57915 DMID-LS-103; PUBMED-DMID-10/11/2005 ; DMID-LSLOAD

Capsid-targeted viral inactivation can destroy dengue 2 virus from within in vitro

Qin, CF and Qin, ED

Arch Virol 2005.


29. 57916 DMID-LS-103; WOS-DMID-10/11/2005 ; DMID-LSLOAD

Potential Impact of Antiviral Drug Use During Influenza Pandemic

Gani, R. et al.

Emerging Infectious Diseases 2005. 11(9): 1355-1362


30. 57917 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Cytotoxicity and antiviral activity of a lignan extracted from Larrea divaricata

Konigheim, BS, Goleniowski, ME, and Contigiani, MS

Drug Design Reviews--Online 2005. 2(1): 81-83

31. 57918 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Studies on the antiviral and cytotoxic activity of Schiff bases derived from 1,2-bis-(o- and p-aminophenoxy)ethane and salicylaldehyde

Bulut, Hakan, Karatepe, Mustafa, Temel, Hamdi, Sekerc, Memet, and Koparir, Metin

Asian Journal of Chemistry 2005. 17(4): 2793-2796

32. 57919 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Screening of antiviral drugs, and pharmaceutical compositions containing 2-thioxothiazolidinone derivatives

Gregor, Paul, Harris, Nicholas, and Zhuk, Regina

PATENT: WO 2005089067 ISSUE DATE: 20050929

APPLICATION: 2005 PP: 52 pp.

ASSIGNEE: (Rimonyx Pharmaceuticals Ltd., Israel

33. 57920 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

CycloSal-pronucleotides of brivudine monophosphate - highly active antiviral agents

Meier, Chris, Meerbach, Astrid, and Wutzler, Peter

Current Medicinal Chemistry: Anti-Infective Agents 2005. 4(4): 317-335

34. 57921 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Antiviral agents from traditional Chinese medicine against herpes simplex virus

Cheng, Chuen-Lung and Xu, Hong-Xi

Journal of Traditional Medicines 2005. 22(Suppl. 1): 133-137

35. 57922 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Antiviral compositions comprising CCL5 (RANTES) fragments or mimetics, or CC chemokine receptor antagonists for inhibiting paramyxovirus infection

Hancock, Gerald Ervin and Tebbey, Paul William

PATENT: WO 2005066205 ISSUE DATE: 20050721

APPLICATION: 2004 PP: 82 pp.

ASSIGNEE: (Wyeth, John and Brother Ltd. USA

36. 57923 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Synthesis of N4-substituted derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, cidofovir, vistide)

Chalupova, Sarka and Holy, Antonin

Collection Symposium Series 2005. 7(Chemistry of Nucleic Acid Components): 387-388

37. 57924 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases

Cheng, Xiaqin, Cook, Gary P, Desai, Manoj C, Doerffler, Edward, He, Gong-Xin, Kim, Choung U, Lee, William A, Rohloff, John C, Wang, Jianying, and Yang, Zheng-Yu

PATENT: WO 2005066189 ISSUE DATE: 20050721

APPLICATION: 2004 PP: 161 pp.

ASSIGNEE: (Gilead Sciences, Inc. USA

38. 57925 DMID-LS-103; SCIFINDER-DMID-10/11/2005 ; DMID-LSLOAD

Murine polyomavirus-VP1 virus-like particles immunize against some polyomavirus-induced tumors

Franzen, Andrea Vlastos, Tegersted, Karin, Hollaenderova, Dana, Forstova, Jitka, Ramqvist, Torbjoern, and Dalianis, Tina

In Vivo 2005. 19(2): 323-326

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