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1. 58219 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Tetrahydro-b-carboline derivatives useful for the treatment of human papillomavirus infection

Gudmundsson, Kristjan, Miller, John Franklin, Sherrill, Ronald George, and Turner, Elizabeth Madalena

PATENT: WO 2006015035 ISSUE DATE: 20060209

APPLICATION: 2005 PP: 51 pp.

ASSIGNEE: (Smithkline Beecham Corporation, USA

2. 58220 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Cidofovir peptide conjugates as prodrugs, their preparation, and therapeutic use thereof

McKenna, Charles E

PATENT: WO 2006014429 ISSUE DATE: 20060209

APPLICATION: 2005 PP: 30 pp.

ASSIGNEE: (University of Southern California (LA), USA

3. 58221 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Microwave-Assisted Synthesis and Anti-Yfv Activity of 2,3-Diaryl-1,3-Thiazolidin-4-Ones

Sriram, D., Yogeeswari, P., and Kumar, T.

Journal of Pharmacy and Pharmaceutical Sciences 2005. 8(3 ): 426-429


4. 58222 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine

Jacquard, AC, Brunelle, MN, Pichoud, C, Durantel, D, Carrouee-Durantel, S, Trepo, C, and Zoulim, F

Antimicrob Agents Chemother 2006. 50(3): 955-61


5. 58223 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease

Perni, RB, Almquist, SJ, Byrn, RA, Chandorkar, G, Chaturvedi, PR, Courtney, LF, Decker, CJ, Dinehart, K, Gates, CA, Harbeson, SL, Heiser, A, Kalkeri, G, Kolaczkowski, E, Lin, K, Luong, YP, Rao, BG, Taylor, WP, Thomson, JA, Tung, RD, Wei, Y, Kwong, AD, and Lin, C

Antimicrob Agents Chemother 2006. 50(3): 899-909


6. 58224 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Agents with leukotriene B4-like antiviral (enveloped RNA) activities

Gosselin, Jean and Borgeat, Pierre

PATENT: US 2006025479 ISSUE DATE: 20060202

APPLICATION: 2004-11016 PP: 28 pp., Cont.-in-part of U.S. Ser. No. 683,882, abandoned.


7. 58225 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase

Loregian, A and Coen, DM

Chem Biol 2006. 13(2): 191-200


8. 58226 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Pyridinylamines and their preparations, pharmaceutical compositions and use for prophylaxis or treatment of various diseases

Eickhoff, Jan Eike, Hafenbradl, Doris, Schwab, Wilfried, Cotton, Matthew, Klebl, Bert Matthias, Zech, Birgit, Mueller, Stefan, Harris, John, Savic, Vladimir, Macritchie, Jackie, Sherborne, Brad, and Le, Joelle

PATENT: WO 2006010637 ISSUE DATE: 20060202

APPLICATION: 2005 PP: 177 pp.

ASSIGNEE: (Gpc Biotech AG, Germany

9. 58227 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Identification of compounds that inhibit the interaction between core and surface protein of hepatitis B virus

Asif-Ullah, M, Choi, KJ, Choi, KI, Jeong, YJ, and Yu, YG

Antiviral Res 2006.


10. 58228 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Inhibition of cell proliferation by SARS-CoV infection in Vero E6 cells

Mizutani, T, Fukushi, S, Iizuka, D, Inanami, O, Kuwabara, M, Takashima, H, Yanagawa, H, Saijo, M, Kurane, I, and Morikawa, S

FEMS Immunol Med Microbiol 2006. 46(2): 236-43


11. 58229 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Preparation of 5-aza-7-deazadeazapurine and C-branched nucleosides as antiviral agents for treating Flaviviridae

Gosselin, Gilles, La Colla, Paolo, Seela, Frank, Storer, Richard, Dukhan, David, and Leroy, Frederic

PATENT: WO 2006000922 ISSUE DATE: 20060105

APPLICATION: 2005 PP: 115 pp.

ASSIGNEE: (Idenix (Cayman) Limited, Cayman I.

12. 58230 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Synthesis and biological evaluation of phosphonated dihydroisoxazole nucleosides

Romeo, G, Iannazzo, D, Piperno, A, Romeo, R, Saglimbeni, M, Chiacchio, MA, Balestrieri, E, Macchi, B, and Mastino, A

Bioorg Med Chem 2006.


13. 58231 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase

Gopalsamy, A, Shi, M, Ciszewski, G, Park, K, Ellingboe, JW, Orlowski, M, Feld, B, and Howe, AY

Bioorg Med Chem Lett 2006.


14. 58232 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

P1 and P1 ' Optimization of [3,4]-Bicycloproline P2 Incorporated Tetrapeptidyl Alpha-Ketoamide Based Hcv Protease Inhibitors

Chen, S. et al.

Letters in Drug Design & Discovery 2005. 2(2): 118-123


15. 58233 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Anti-Viral Therapies for Hepatitis C Virus Infection: Current Options and Evolving Candidate Drugs

Fanning, L.

Letters in Drug Design & Discovery 2005. 2(2): 150-161


16. 58234 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Phenyldihydroxypyrimidines as Hcvns5b Rna Dependent Rna Polymerase Inhibitors. Part 1: Amides and Ureas

Crescenzi, B. et al.

Letters in Drug Design & Discovery 2005. 2(6): 451-455


17. 58235 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Comparative Activities of Oseltamivir and A-322278 in Immunocompetent and Immunocompromised Murine Models of Influenza Virus Infection

Ison, MG, Mishin, VP, Braciale, TJ, Hayden, FG, and Gubareva, LV

J Infect Dis 2006. 193(6): 765-772


18. 58236 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Phenyldihydroxypyrimidines as Hcvns5b Rna Dependent Rna Polymerase Inhibitors. Part Ii: Sulfonamides

Ponzi, S. et al.

Letters in Drug Design & Discovery 2005. 2(6): 456-461


19. 58237 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Novel Inhibitors of Hepatitis C Virus RNA-dependent RNA Polymerases

Lee, G, Piper, DE, Wang, Z, Anzola, J, Powers, J, Walker, N, and Li, Y

J Mol Biol 2006.


20. 58238 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Inhibitors of Hepatitis C Virus Ns3 Center Dot 4a Protease: P-2 Proline Variants

Farmer, L. et al.

Letters in Drug Design & Discovery 2005. 2(7): 497-502


21. 58239 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Antiviral Activity of Transiently Expressed Ifn-Kappa Is Cell-Associated

Buontempo, P. et al.

Journal of Interferon and Cytokine Research 2006. 26(1): 40-52


22. 58240 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Characterization of the antiviral effects of interferon-alpha against a SARS-like coronoavirus infection in vitro

Zorzitto, J, Galligan, CL, Ueng, JJ, and Fish, EN

Cell Res 2006. 16(2): 220-229


23. 58241 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Development of Antiviral Drugs Targeting the Flaviviruses Fusion Mechanism

Kampmann, T. et al.

Febs Journal 2005. 272: 553


24. 58242 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

Hammerhead ribozymes with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells

Gonzalez-Carmona, MA, Schussler, S, Serwe, M, Alt, M, Ludwig, J, Sproat, BS, Steigerwald, R, Hoffmann, P, Quasdorff, M, Schildgen, O, and Caselmann, WH

J Hepatol 2005.


25. 58243 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Peroxisome Proliferator-Activated Receptor Alpha Antagonism Inhibits Hepatitis C Virus Replication

Rakic, B. et al.

Chemistry & Biology 2006. 13(1): 23-30


26. 58244 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

ent-epiafzelechin-(4a->8)-epiafzelechin extracted from Cassia javanica inhibits herpes simplex virus type 2 replication

Cheng, Hua-Yew, Yang, Chien-Min, Lin, Ta-Chen, Shieh, Den-En, and Lin, Chun-Ching

Journal of Medical Microbiology 2006. 55(2): 201-206

27. 58245 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

2-Substituted Furans from the Roots of Polyalthia evecta

Kanokmedhakul, Somdej, Kanokmedhakul, Kwanjai, Kantikeaw, Itsara, and Phonkerd, Nutchanat

Journal of Natural Products 2006. 69(1): 68-72

28. 58246 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD

The protein phosphatase 2A represents a novel cellular target for hepatitis C virus NS5A protein

Georgopoulou, U, Tsitoura, P, Kalamvoki, M, and Mavromara, P

Biochimie 2006.


29. 58247 DMID-LS-113; PUBMED-DMID-2/27/2006 ; DMID-LSLOAD


Moore, ZS, Seward, JF, and Lane, JM

Lancet 2006. 367(9508): 425-35


30. 58248 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Owl monkey polynucleotide encoding a TRIM5-cyclophilin A fusion protein, and its use in treating HIV-1 and other viral infections

Luban, Jeremy and Sayah, David

PATENT: WO 2006014422 ISSUE DATE: 20060209

APPLICATION: 2005 PP: 62 pp.

ASSIGNEE: (The Trustees of Columbia University In the City of New York, USA

31. 58249 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Inhibition of the Hepatitis B Virus Replication in Vitro by an Oligodeoxynucleotide Containing Cytidine-Guano Sine Motifs

Ning, L. et al.

Immunology Letters 2006. 102(1): 60-66


32. 58250 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation

Zhou, Longhu, Amer, Adel, Korn, Michael, Burda, Robert, Balzarini, Jan, De Clercq, Erik, Kern, Earl R, and Torrence, Paul F

Antiviral Chemistry & Chemotherapy 2005. 16(6): 375-383

33. 58251 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Aromatic Polycationic Molecules With Restricted Conformations: an Alternative Approach to Antiherpes Agents

Tsotinis, A. et al.

Letters in Drug Design & Discovery 2005. 2(5): 424-427


34. 58252 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

RNA-dependent RNA polymerase from SARS CoV and its homologs from other coronaviruses and their use in molecular biology and drug screening

Imbert, Isabelle, Guillemot, Jean-Claude, Canard, Bruno, and Ferron, Francois-Patrice

PATENT: EP 1619246 ISSUE DATE: 20060125

APPLICATION: 2004-29735 PP: 27 pp.

ASSIGNEE: (Universite de la Mediterranee, Aix-Marseille II Fr.

35. 58253 DMID-LS-113; LR-14709-LWC; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture

Balzarini, Jan, Keyaerts, Els, Vijgen, Leen, Vandermeer, Frank, Stevens, Miguel, De Clercq, Erik, Egberink, Herman, and Van Ranst, Marc

Journal of Antimicrobial Chemotherapy 2006. 57(3): 472-481

36. 58254 DMID-LS-113; SCIFINDER-DMID-2/27/2006 ; DMID-LSLOAD

Therapeutic agents for human papilloma virus disease and anti human immunodeficiency virus medicine

Sakagami, Hiroshi, Kawazoe, Yutaka, Otsuki, Mamitarou, Inaba, Youichi, Sai, Bun, Horiuchi, Akira, Nakajima, Hideki, and Aratsu, Chiaki

PATENT: WO 2006001364 ISSUE DATE: 20060105

APPLICATION: 2005 PP: 28 pp.

ASSIGNEE: (Nihonsyouyaku Laboratory Corporation, Japan

37. 58255 DMID-LS-113; WOS-DMID-2/27/2006 ; DMID-LSLOAD

Avian Influenza Virus Infections in Humans

Wong, S. and Yuen, K.

Chest 2006. 129(1): 156-168


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