ONLINE DATABASE SEARCH - DMID-LS-123-MEMO
1. 58622 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities
Chang, KS, Cai, Z, Zhang, C, Sen, GC, Williams, BR, and Luo, G
J Virol 2006. 80(15): 7364-74
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16840317&dopt=abstract
2. 58623 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
Synthesis and antiviral activity of novel phenyl branched apiosyl nucleosides
Kim, JW and Hong, JH
Arch Pharm Res 2006. 29(6): 464-8
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16833012&dopt=abstract
3. 58624 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
Biswal, BK, Wang, M, Cherney, MM, Chan, L, Yannopoulos, CG, Bilimoria, D, Bedard, J, and James, MN
J Mol Biol 2006.
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16828488&dopt=abstract
4. 58625 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
Pivotal role of animal models in the development of new therapies for cytomegalovirus infections
Kern, ER
Antiviral Res 2006.
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16828175&dopt=abstract
5. 58626 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure
Fan, X, Zhang, X, Zhou, L, Keith, KA, Prichard, MN, Kern, ER, and Torrence, PF
J Med Chem 2006. 49(14): 4052-4
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16821766&dopt=abstract
6. 58627 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
New antiviral agents
Abdel-Haq, N, Chearskul, P, Al-Tatari, H, and Asmar, B
Indian J Pediatr 2006. 73(4): 313-21
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16816493&dopt=abstract
7. 58628 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
Antivirals for influenza: Historical perspectives and lessons learned
Hayden, FG
Antiviral Res 2006.
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16815563&dopt=abstract
8. 58629 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
Discovery of a novel series of inhibitors of human cytomegalovirus primase
Cushing, TD, Adrian, J, Chen, X, Dimaio, H, Doughan, B, Flygare, J, Liang, L, Mayorga, V, Miao, S, Mellon, H, Peterson, MG, Powers, JP, Spector, F, Stein, C, Wright, M, Xu, D, Ye, Q, and Jaen, J
Bioorg Med Chem Lett 2006.
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16814545&dopt=abstract
9. 58630 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever virus infections, including infections associated with arenaviruses
Deng, Yijun, Nitz, Theodore J, Bailey, Thomas R, Zhang, Yanming, and Laquerre, Sylvie
PATENT: WO 2006062898 ISSUE DATE: 20060615
APPLICATION: 2005 PP: 127 pp.
ASSIGNEE: (Siga Technologies, Inc. USA
10. 58631 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD
l-Nucleoside enantiomers as antivirals drugs: A mini-review
Mathe, C and Gosselin, G
Antiviral Res 2006.
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16797735&dopt=abstract
11. 58632 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Antisense, nuclease-resistant oligonucleotides targeting VP24, VP35, and L genes of filovirus for use as antiviral agents
Stein, David A, Iversen, Patrick L, and Bavari, Sina
PATENT: WO 2006050414 ISSUE DATE: 20060511
APPLICATION: 2005 PP: 81 pp.
ASSIGNEE: (Avi Biopharma, Inc. USA
12. 58633 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Preparation of ethynyl uridine derivatives as antiviral drugs against Flaviviridae, especially HCV
Aucagne, Vincent, Escuret, Vanessa, Zoulim, Fabien, Durantel, David, Trepo, Christian, Agrofoglio, Luigi, Joubert, Nicolas, and Amblard, Franck
PATENT: EP 1674104 ISSUE DATE: 20060628
APPLICATION: 2004-28527 PP: 29 pp.
ASSIGNEE: (Institut National De La Sante Et De La Recherche Medicale (Inserm), Fr. and Centre National De La Recherche Scientifique (CNRS))
13. 58634 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Preparation of cyclobutyl nucleosides for use in the treatment of infections including Retroviridae, Hepadnaviridae, or Flaviviridae in animals and humans
Liotta, Dennis C, Mao, Shuli, and Hager, Michael
PATENT: WO 2006063281 ISSUE DATE: 20060615
APPLICATION: 2005 PP: 138 pp.
ASSIGNEE: (Emory University, USA
14. 58635 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Preparation of 3-phenyl-9H-thioxanthen-9-one derivatives as inhibitors of flavivirus replication
Gilbertson, Scott R, Lory, Pedro J, Malmstrom, Robert D, Pang, Yuan-Ping, Russo, Andrew T, and Watowich, Stanley J
PATENT: WO 2006060774 ISSUE DATE: 20060608
APPLICATION: 2005 PP: 107 pp.
ASSIGNEE: (Board of Regents, The University of Texas System USA and Mayo Foundation for Medical Education and Research)
15. 58636 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Antiviral Activities of Purified Compounds From Youngia Japonica (L.) Dc (Asteraceae, Compositae)
Ooi, L. et al.
Journal of Ethnopharmacology 2006. 106(2): 187-191
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238457600006
16. 58637 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Valopicitabine - Anti-Hepatitis C Virus Drug Rna-Directed Rna Polymerase (Ns5b) Inhibitor
Sorbera, L., Castaner, J., and Leeson, P.
Drugs of the Future 2006. 31(4): 320-324
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238516600005
17. 58638 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Influenza Therapies: Vaccines and Antiviral Drugs
Quigley, E.
Drug Discovery Today 2006. 11(11-12): 478-480
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238523500002
18. 58639 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl-2-(Hydroxymethyl) Purine Bases and Nucleosides
Silhar, P. et al.
Collection of Czechoslovak Chemical Communications 2006. 71(6): 788-803
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238419500004
19. 58640 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Antiretroviral Therapy 2006: Pharmacology, Applications, and Special Situations
Samuel, R., Bettiker, R., and Suh, B.
Archives of Pharmacal Research 2006. 29(6): 431-458
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238660500001
20. 58641 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Efficient Inhibition of Hepatitis B Virus Replication by Small Interfering Rnas Targeted to the Viral X Gene in Mice
Shin, D. et al.
Virus Research 2006. 119(2): 146-153
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238438700003
21. 58642 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
A Protease Inhibitor Specifically Inhibits Growth of Hpv-Infected Keratinocytes
Drubin, D. et al.
Molecular Therapy 2006. 13(6): 1142-1148
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238402000015
22. 58643 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
N- and 6-O-Sulfated Heparan Sulfates Mediate Internalization of Coxsackievirus B3 Variant Pd Into Cho-K1 Cells
Zautner, A. et al.
Journal of Virology 2006. 80(13): 6629-6636
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238380700044
23. 58644 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Morpholino antisense drugs for human herpesvirus 8 (HHV8)
Zhang, Yan-Jin and Matson, David O
PATENT: WO 2006010041 ISSUE DATE: 20060126
APPLICATION: 2005 PP: 81 pp.
ASSIGNEE: (Eastern Virginia Medical School, USA
24. 58645 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity
Goodell, John R, Madhok, Avni A, Hiasa, Hiroshi, and Ferguson, David M
Bioorganic & Medicinal Chemistry 2006. 14(16): 5467-5480
25. 58646 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Synthesis and Biological Evaluation of 5-(Alkyn-1-Yl)-1-(P-Toluenesulfonyl)Uracil Derivatives
Janeba, Z. et al.
Canadian Journal of Chemistry-Revue Canadienne De Chimie 2006. 84(4): 580-586
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238285200016
26. 58647 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Synthesis, Characterization, and Biological Activity of Amino Acid Derivatives of the Heteropolytungstophosphoric Acid
Kuntic, Vesna, Stanojevic, Maja, Holclajtner-Antunovic, Ivanka, Uskokovic-Markovic, Snezana, Mioc, Ubavka, Todorovic, Marija, Jovanovic, Tanja, and Vukojevic, Vladana
Monatshefte fuer Chemie 2006. 137(6): 803-810
27. 58648 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Inhibition of the NF-kB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo
Jones, Jeremy O and Arvin, Ann M
Journal of Virology 2006. 80(11): 5113-5124
28. 58649 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Thiadiazole pyrimidine derivatives as antiviral agents
Xue, Sijia and Sun, Chuanwen
PATENT: CN 1771958 ISSUE DATE: 20060517
APPLICATION: 1011-27 PP: 10 pp.
ASSIGNEE: (Shanghai Normal University, Peop. Rep. China
29. 58650 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Inhibition of Measles Virus and Subacute Sclerosing Panencephalitis Virus by Rna Interference
Otaki, M. et al.
Antiviral Research 2006. 70(3): 105-111
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238397000002
30. 58651 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Combination Chemotherapy, a Potential Strategy for Reducing the Emergence of Drug-Resistant Influenza a Variants
Ilyushina, N. et al.
Antiviral Research 2006. 70(3): 121-131
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000238397000004
31. 58652 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Method for construction of hepatitis C virus-transgenic mouse model, and its application in antiviral drug screening
Zhan, Linsheng, Wang, Quanli, Rao, Lin, and Peng, Jianchun
PATENT: CN 1718731 ISSUE DATE: 20060111
APPLICATION: 1006-2739 PP: 8 pp.
ASSIGNEE: (Institute of Field Transfusion, Academy of Military Medical Sciences Pla Peop. Rep. China
32. 58653 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Baraclude (Tm) (Entecavir), a Potent and Selective Inhibitor of Hbv-Rt: Molecular Mechanism(S) of Resistance in Viruses With Pre-Existing Lamivudine Resistance Substitutions
Langley, D. et al.
Abstracts of Papers of the American Chemical Society 2005. 230: U1398-U1399
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000236797302821
33. 58654 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Molecular Modeling of Covalent Complexes and Structural-Based Design of Irreversible Inhibitors of Rhinovirus 3c Protease
Hou, X. et al.
Abstracts of Papers of the American Chemical Society 2005. 230: U1399
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000236797302822
34. 58655 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Triazoles useful as inhibitors of protein kinases and their preparation, pharmaceutical compositions, and use for treatment of various disorders
Davies, Robert J, Forster, Cornelia J, Arnost, Michael J, and Wang, Jian
PATENT: WO 2006047256 ISSUE DATE: 20060504
APPLICATION: 2005 PP: 91 pp.
ASSIGNEE: (Vertex Pharmaceuticals Inc., USA
35. 58656 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
M-Tyrosine- and Tic-Based Macrocyclic Inhibitors of Hepatitis C Virus (Hcv) Ns3 Protease: Synthesis and Biological Activity
Chen, K. et al.
Abstracts of Papers of the American Chemical Society 2005. 230: U2602-U2603
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000236797305162
36. 58657 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Design and Synthesis of Depeptidized P2-P4 Biaryl Macrocyclic Inhibitors of Hepatitis-C Ns3-4a Protease
Venkatraman, S. et al.
Abstracts of Papers of the American Chemical Society 2005. 230: U2605
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000236797305167
37. 58658 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Isatin Oximes as Inhibitors of Respiratory Syncytial Virus Fusion
Venables, B. et al.
Abstracts of Papers of the American Chemical Society 2005. 230: U2609
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000236797305171
38. 58659 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Discovery of Sch 503034, a Selective, Potent Hcvns3 Protease Inhibitor With Oral Bioavailability: Potential Therapeutic Agent for Treating Hepatitis C Viral Infection
Njoroge, F. et al.
Abstracts of Papers of the American Chemical Society 2005. 230: U2647-U2648
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000236797305241
39. 58660 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Lead Optimization of Hepatitis C Viral Polymerase Inhibitors: an Acyl Pyrrolidine Development Candidate
Slater, M.
Abstracts of Papers of the American Chemical Society 2005. 230: U2648
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000236797305242
40. 58661 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD
Highly Stereoselective Synthesis of Bicyclic-Acetal-Based Macrocyclic Inhibitors of Hepatitis C Virus
Chen, K. and Njoroge, F.
Abstracts of Papers of the American Chemical Society 2005. 230: U3341
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000236797306520
41. 58662 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Peptides for the treatment of viral infections, including herpes virus infections
Forssmann, Wolf-Georg, Kirchhoff, Frank, Muench, Jan, and Staendker, Ludger
PATENT: WO 2006018431 ISSUE DATE: 20060223
APPLICATION: 2005 PP: 13 pp.
ASSIGNEE: (IPF Pharmaceuticals G.m.b.H., Germany
42. 58663 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses
Beadle James R, Wan William B, Ciesla Stephanie L, Keith Kathy A, Hartline Caroll, Kern Earl R, and Hostetler Karl Y
Journal of medicinal chemistry 2006. 49(6): 2010-5.
43. 58664 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection
Malakhov Michael P, Aschenbrenner Laura M, Smee Donald F, Wandersee Miles K, Sidwell Robert W, Gubareva Larisa V, Mishin Vasiliy P, Hayden Frederick G, Kim Do Hyong, Ing Alice, Campbell Erin R, Yu Mang, and Fang Fang
Antimicrobial agents and chemotherapy 2006. 50(4): 1470-9.
44. 58665 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Recent advances in anti-influenza agents with neuraminidase as target
Zhang Jie and Xu Wenfang
Mini reviews in medicinal chemistry 2006. 6(4): 429-48.
45. 58666 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections
Prichard Mark N, Keith Kathy A, Quenelle Debra C, and Kern Earl R
Antimicrobial agents and chemotherapy 2006. 50(4): 1336-41.
46. 58667 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals
Soerensen, Morten Draeby, Soerensen, Brian, Gonzalez-Dosal, Regina, Melchjorsen, Connie Jenning, Weibel, Jens, Wang, Jing, Jun, Chen Wie, Yang, Huanming, and Kristensen, Peter
Annals of the New York Academy of Sciences 2006. 1067(Understanding and Modulating Aging): 500-505
47. 58668 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD
Potential antivirals and antiviral strategies against SARS coronavirus infections
De Clercq, Erik
Expert Review of Anti-Infective Therapy 2006. 4(2): 291-302