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1. 58622 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities

Chang, KS, Cai, Z, Zhang, C, Sen, GC, Williams, BR, and Luo, G

J Virol 2006. 80(15): 7364-74


2. 58623 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

Synthesis and antiviral activity of novel phenyl branched apiosyl nucleosides

Kim, JW and Hong, JH

Arch Pharm Res 2006. 29(6): 464-8


3. 58624 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition

Biswal, BK, Wang, M, Cherney, MM, Chan, L, Yannopoulos, CG, Bilimoria, D, Bedard, J, and James, MN

J Mol Biol 2006.


4. 58625 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

Pivotal role of animal models in the development of new therapies for cytomegalovirus infections

Kern, ER

Antiviral Res 2006.


5. 58626 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure

Fan, X, Zhang, X, Zhou, L, Keith, KA, Prichard, MN, Kern, ER, and Torrence, PF

J Med Chem 2006. 49(14): 4052-4


6. 58627 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

New antiviral agents

Abdel-Haq, N, Chearskul, P, Al-Tatari, H, and Asmar, B

Indian J Pediatr 2006. 73(4): 313-21


7. 58628 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

Antivirals for influenza: Historical perspectives and lessons learned

Hayden, FG

Antiviral Res 2006.


8. 58629 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

Discovery of a novel series of inhibitors of human cytomegalovirus primase

Cushing, TD, Adrian, J, Chen, X, Dimaio, H, Doughan, B, Flygare, J, Liang, L, Mayorga, V, Miao, S, Mellon, H, Peterson, MG, Powers, JP, Spector, F, Stein, C, Wright, M, Xu, D, Ye, Q, and Jaen, J

Bioorg Med Chem Lett 2006.


9. 58630 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever virus infections, including infections associated with arenaviruses

Deng, Yijun, Nitz, Theodore J, Bailey, Thomas R, Zhang, Yanming, and Laquerre, Sylvie

PATENT: WO 2006062898 ISSUE DATE: 20060615

APPLICATION: 2005 PP: 127 pp.

ASSIGNEE: (Siga Technologies, Inc. USA

10. 58631 DMID-LS-123; PUBMED-DMID-7/17/2006 ; DMID-LSLOAD

l-Nucleoside enantiomers as antivirals drugs: A mini-review

Mathe, C and Gosselin, G

Antiviral Res 2006.


11. 58632 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Antisense, nuclease-resistant oligonucleotides targeting VP24, VP35, and L genes of filovirus for use as antiviral agents

Stein, David A, Iversen, Patrick L, and Bavari, Sina

PATENT: WO 2006050414 ISSUE DATE: 20060511

APPLICATION: 2005 PP: 81 pp.

ASSIGNEE: (Avi Biopharma, Inc. USA

12. 58633 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Preparation of ethynyl uridine derivatives as antiviral drugs against Flaviviridae, especially HCV

Aucagne, Vincent, Escuret, Vanessa, Zoulim, Fabien, Durantel, David, Trepo, Christian, Agrofoglio, Luigi, Joubert, Nicolas, and Amblard, Franck

PATENT: EP 1674104 ISSUE DATE: 20060628

APPLICATION: 2004-28527 PP: 29 pp.

ASSIGNEE: (Institut National De La Sante Et De La Recherche Medicale (Inserm), Fr. and Centre National De La Recherche Scientifique (CNRS))

13. 58634 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Preparation of cyclobutyl nucleosides for use in the treatment of infections including Retroviridae, Hepadnaviridae, or Flaviviridae in animals and humans

Liotta, Dennis C, Mao, Shuli, and Hager, Michael

PATENT: WO 2006063281 ISSUE DATE: 20060615

APPLICATION: 2005 PP: 138 pp.

ASSIGNEE: (Emory University, USA

14. 58635 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Preparation of 3-phenyl-9H-thioxanthen-9-one derivatives as inhibitors of flavivirus replication

Gilbertson, Scott R, Lory, Pedro J, Malmstrom, Robert D, Pang, Yuan-Ping, Russo, Andrew T, and Watowich, Stanley J

PATENT: WO 2006060774 ISSUE DATE: 20060608

APPLICATION: 2005 PP: 107 pp.

ASSIGNEE: (Board of Regents, The University of Texas System USA and Mayo Foundation for Medical Education and Research)

15. 58636 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Antiviral Activities of Purified Compounds From Youngia Japonica (L.) Dc (Asteraceae, Compositae)

Ooi, L. et al.

Journal of Ethnopharmacology 2006. 106(2): 187-191


16. 58637 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Valopicitabine - Anti-Hepatitis C Virus Drug Rna-Directed Rna Polymerase (Ns5b) Inhibitor

Sorbera, L., Castaner, J., and Leeson, P.

Drugs of the Future 2006. 31(4): 320-324


17. 58638 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Influenza Therapies: Vaccines and Antiviral Drugs

Quigley, E.

Drug Discovery Today 2006. 11(11-12): 478-480


18. 58639 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Synthesis of 6-Amino-, 6-Methyl- and 6-Aryl-2-(Hydroxymethyl) Purine Bases and Nucleosides

Silhar, P. et al.

Collection of Czechoslovak Chemical Communications 2006. 71(6): 788-803


19. 58640 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Antiretroviral Therapy 2006: Pharmacology, Applications, and Special Situations

Samuel, R., Bettiker, R., and Suh, B.

Archives of Pharmacal Research 2006. 29(6): 431-458


20. 58641 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Efficient Inhibition of Hepatitis B Virus Replication by Small Interfering Rnas Targeted to the Viral X Gene in Mice

Shin, D. et al.

Virus Research 2006. 119(2): 146-153


21. 58642 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

A Protease Inhibitor Specifically Inhibits Growth of Hpv-Infected Keratinocytes

Drubin, D. et al.

Molecular Therapy 2006. 13(6): 1142-1148


22. 58643 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

N- and 6-O-Sulfated Heparan Sulfates Mediate Internalization of Coxsackievirus B3 Variant Pd Into Cho-K1 Cells

Zautner, A. et al.

Journal of Virology 2006. 80(13): 6629-6636


23. 58644 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Morpholino antisense drugs for human herpesvirus 8 (HHV8)

Zhang, Yan-Jin and Matson, David O

PATENT: WO 2006010041 ISSUE DATE: 20060126

APPLICATION: 2005 PP: 81 pp.

ASSIGNEE: (Eastern Virginia Medical School, USA

24. 58645 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity

Goodell, John R, Madhok, Avni A, Hiasa, Hiroshi, and Ferguson, David M

Bioorganic & Medicinal Chemistry 2006. 14(16): 5467-5480

25. 58646 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Synthesis and Biological Evaluation of 5-(Alkyn-1-Yl)-1-(P-Toluenesulfonyl)Uracil Derivatives

Janeba, Z. et al.

Canadian Journal of Chemistry-Revue Canadienne De Chimie 2006. 84(4): 580-586


26. 58647 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Synthesis, Characterization, and Biological Activity of Amino Acid Derivatives of the Heteropolytungstophosphoric Acid

Kuntic, Vesna, Stanojevic, Maja, Holclajtner-Antunovic, Ivanka, Uskokovic-Markovic, Snezana, Mioc, Ubavka, Todorovic, Marija, Jovanovic, Tanja, and Vukojevic, Vladana

Monatshefte fuer Chemie 2006. 137(6): 803-810

27. 58648 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Inhibition of the NF-kB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo

Jones, Jeremy O and Arvin, Ann M

Journal of Virology 2006. 80(11): 5113-5124

28. 58649 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Thiadiazole pyrimidine derivatives as antiviral agents

Xue, Sijia and Sun, Chuanwen

PATENT: CN 1771958 ISSUE DATE: 20060517

APPLICATION: 1011-27 PP: 10 pp.

ASSIGNEE: (Shanghai Normal University, Peop. Rep. China

29. 58650 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Inhibition of Measles Virus and Subacute Sclerosing Panencephalitis Virus by Rna Interference

Otaki, M. et al.

Antiviral Research 2006. 70(3): 105-111


30. 58651 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Combination Chemotherapy, a Potential Strategy for Reducing the Emergence of Drug-Resistant Influenza a Variants

Ilyushina, N. et al.

Antiviral Research 2006. 70(3): 121-131


31. 58652 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Method for construction of hepatitis C virus-transgenic mouse model, and its application in antiviral drug screening

Zhan, Linsheng, Wang, Quanli, Rao, Lin, and Peng, Jianchun

PATENT: CN 1718731 ISSUE DATE: 20060111

APPLICATION: 1006-2739 PP: 8 pp.

ASSIGNEE: (Institute of Field Transfusion, Academy of Military Medical Sciences Pla Peop. Rep. China

32. 58653 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Baraclude (Tm) (Entecavir), a Potent and Selective Inhibitor of Hbv-Rt: Molecular Mechanism(S) of Resistance in Viruses With Pre-Existing Lamivudine Resistance Substitutions

Langley, D. et al.

Abstracts of Papers of the American Chemical Society 2005. 230: U1398-U1399


33. 58654 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Molecular Modeling of Covalent Complexes and Structural-Based Design of Irreversible Inhibitors of Rhinovirus 3c Protease

Hou, X. et al.

Abstracts of Papers of the American Chemical Society 2005. 230: U1399


34. 58655 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Triazoles useful as inhibitors of protein kinases and their preparation, pharmaceutical compositions, and use for treatment of various disorders

Davies, Robert J, Forster, Cornelia J, Arnost, Michael J, and Wang, Jian

PATENT: WO 2006047256 ISSUE DATE: 20060504

APPLICATION: 2005 PP: 91 pp.

ASSIGNEE: (Vertex Pharmaceuticals Inc., USA

35. 58656 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

M-Tyrosine- and Tic-Based Macrocyclic Inhibitors of Hepatitis C Virus (Hcv) Ns3 Protease: Synthesis and Biological Activity

Chen, K. et al.

Abstracts of Papers of the American Chemical Society 2005. 230: U2602-U2603


36. 58657 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Design and Synthesis of Depeptidized P2-P4 Biaryl Macrocyclic Inhibitors of Hepatitis-C Ns3-4a Protease

Venkatraman, S. et al.

Abstracts of Papers of the American Chemical Society 2005. 230: U2605


37. 58658 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Isatin Oximes as Inhibitors of Respiratory Syncytial Virus Fusion

Venables, B. et al.

Abstracts of Papers of the American Chemical Society 2005. 230: U2609


38. 58659 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Discovery of Sch 503034, a Selective, Potent Hcvns3 Protease Inhibitor With Oral Bioavailability: Potential Therapeutic Agent for Treating Hepatitis C Viral Infection

Njoroge, F. et al.

Abstracts of Papers of the American Chemical Society 2005. 230: U2647-U2648


39. 58660 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Lead Optimization of Hepatitis C Viral Polymerase Inhibitors: an Acyl Pyrrolidine Development Candidate

Slater, M.

Abstracts of Papers of the American Chemical Society 2005. 230: U2648


40. 58661 DMID-LS-123; WOS-DMID-7/17/2006 ; DMID-LSLOAD

Highly Stereoselective Synthesis of Bicyclic-Acetal-Based Macrocyclic Inhibitors of Hepatitis C Virus

Chen, K. and Njoroge, F.

Abstracts of Papers of the American Chemical Society 2005. 230: U3341


41. 58662 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Peptides for the treatment of viral infections, including herpes virus infections

Forssmann, Wolf-Georg, Kirchhoff, Frank, Muench, Jan, and Staendker, Ludger

PATENT: WO 2006018431 ISSUE DATE: 20060223

APPLICATION: 2005 PP: 13 pp.

ASSIGNEE: (IPF Pharmaceuticals G.m.b.H., Germany

42. 58663 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses

Beadle James R, Wan William B, Ciesla Stephanie L, Keith Kathy A, Hartline Caroll, Kern Earl R, and Hostetler Karl Y

Journal of medicinal chemistry 2006. 49(6): 2010-5.

43. 58664 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection

Malakhov Michael P, Aschenbrenner Laura M, Smee Donald F, Wandersee Miles K, Sidwell Robert W, Gubareva Larisa V, Mishin Vasiliy P, Hayden Frederick G, Kim Do Hyong, Ing Alice, Campbell Erin R, Yu Mang, and Fang Fang

Antimicrobial agents and chemotherapy 2006. 50(4): 1470-9.

44. 58665 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Recent advances in anti-influenza agents with neuraminidase as target

Zhang Jie and Xu Wenfang

Mini reviews in medicinal chemistry 2006. 6(4): 429-48.

45. 58666 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections

Prichard Mark N, Keith Kathy A, Quenelle Debra C, and Kern Earl R

Antimicrobial agents and chemotherapy 2006. 50(4): 1336-41.

46. 58667 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals

Soerensen, Morten Draeby, Soerensen, Brian, Gonzalez-Dosal, Regina, Melchjorsen, Connie Jenning, Weibel, Jens, Wang, Jing, Jun, Chen Wie, Yang, Huanming, and Kristensen, Peter

Annals of the New York Academy of Sciences 2006. 1067(Understanding and Modulating Aging): 500-505

47. 58668 DMID-LS-123; SCIFINDER-DMID-7/17/2006 ; DMID-LSLOAD

Potential antivirals and antiviral strategies against SARS coronavirus infections

De Clercq, Erik

Expert Review of Anti-Infective Therapy 2006. 4(2): 291-302

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