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1. 58918 DMID-LS-127; PUBMED-DMID-9/11/2006

Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes

Kudchodkar, SB, Yu, Y, Maguire, TG, and Alwine, JC

Proc Natl Acad Sci U S A 2006.


2. 58919 DMID-LS-127; PUBMED-DMID-9/11/2006

Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis

Yee, NK, Farina, V, Houpis, IN, Haddad, N, Frutos, RP, Gallou, F, Wang, XJ, Wei, X, Simpson, RD, Feng, X, Fuchs, V, Xu, Y, Tan, J, Zhang, L, Xu, J, Smith-Keenan, LL, Vitous, J, Ridges, MD, Spinelli, EM, Johnson, M, Donsbach, K, Nicola, T, Brenner, M, Winter, E, Kreye, P, and Samstag, W

J Org Chem 2006. 71(19): 7133-45


3. 58920 DMID-LS-127; SCIFINDER-DMID-9/11/2006

N-halogenated and N,N-dihalogenated amino acids in combination with hypohalous acids for use as antimicrobial agents

Najafi, Ramin, Bassiri, Mansour, Wang, Lu, and Khosrovi, Behzad

PATENT: WO 2006081392 ISSUE DATE: 20060803

APPLICATION: 2006 PP: 72pp.

ASSIGNEE: (Novacal Pharmaceuticals, Inc. USA

4. 58921 DMID-LS-127; PUBMED-DMID-9/11/2006

Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions

Klingstrom, J, Akerstrom, S, Hardestam, J, Stoltz, M, Simon, M, Falk, KI, Mirazimi, A, Rottenberg, M, and Lundkvist, A

Eur J Immunol 2006.


5. 58922 DMID-LS-127; PUBMED-DMID-9/11/2006

Antiviral effect of octyl gallate against DNA and RNA viruses

Uozaki, M, Yamasaki, H, Katsuyama, Y, Higuchi, M, Higuti, T, and Koyama, AH

Antiviral Res 2006.


6. 58923 DMID-LS-127; PUBMED-DMID-9/11/2006

Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay

Shaneyfelt, ME, Burke, AD, Graff, JW, Jutila, MA, and Hardy, ME

Virol J 2006. 3(1): 68


7. 58924 DMID-LS-127; PUBMED-DMID-9/11/2006

Molecular modeling studies of peptide drug candidates against SARS

Zhang, R, Wei, DQ, Du, QS, and Chou, KC

Med Chem 2006. 2(3): 309-14


8. 58925 DMID-LS-127; PUBMED-DMID-9/11/2006

Antiviral Targets of a Chromene Derivative from Sargassum micracanthum in the Replication of Human Cytomegalovirus

Hayashi, K, Mori, J, Saito, H, and Hayashi, T

Biol Pharm Bull 2006. 29(9): 1843-7


9. 58926 DMID-LS-127; PUBMED-DMID-9/11/2006

Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents

Varaprasad, CV, Ramasamy, KS, Girardet, JL, Gunic, E, Lai, V, Zhong, W, An, H, and Hong, Z

Bioorg Chem 2006.


10. 58927 DMID-LS-127; PUBMED-DMID-9/11/2006

Inhibition of the replication of hepatitis B virus in vitro by emodin

Shuangsuo, D, Zhengguo, Z, Yunru, C, Xin, Z, Baofeng, W, Lichao, Y, and Yan'an, C

Med Sci Monit 2006. 12(9): BR302-306


11. 58928 DMID-LS-127; PUBMED-DMID-9/11/2006

NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon

Ma, S, Boerner, JE, Tiongyip, C, Weidmann, B, Ryder, NS, Cooreman, MP, and Lin, K

Antimicrob Agents Chemother 2006. 50(9): 2976-82


12. 58929 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Antiviral activity from medicinal mushrooms

Stamets, Paul

PATENT: US 2006171958 ISSUE DATE: 20060803

APPLICATION: 2006-58722 PP: 14pp., Cont.-in-part of U.S. Ser. No. 145,679.


13. 58930 DMID-LS-127; PUBMED-DMID-9/11/2006

Natural variation can significantly alter sensitivity to oseltamivir of Influenza A(H5N1) viruses

Rameix-Welti, MA, Agou, F, Buchy, P, Mardy, S, Aubin, JT, Veron, M, van, der Werf S, and Naffakh, N

Antimicrob Agents Chemother 2006.


14. 58931 DMID-LS-127; PUBMED-DMID-9/11/2006

Synergistic effect of a novel oxymatrine-baicalin combination against hepatitis B virus replication, alpha smooth muscle actin expression and type I collagen synthesis in vitro

Cheng, Y, Ping, J, Xu, HD, Fu, HJ, and Zhou, ZH

World J Gastroenterol 2006. 12(32): 5153-9


15. 58932 DMID-LS-127; PUBMED-DMID-9/11/2006

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors

Yan, S, Appleby, T, Larson, G, Wu, JZ, Hamatake, R, Hong, Z, and Yao, N

Bioorg Med Chem Lett 2006.


16. 58933 DMID-LS-127; PUBMED-DMID-9/11/2006

Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes

Dalton, RM, Mullin, AE, Amorim, MJ, Medcalf, E, Tiley, LS, and Digard, P

Virol J 2006. 3(1): 58


17. 58934 DMID-LS-127; PUBMED-DMID-9/11/2006

CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch

Brown, DM, Dilzer, AM, Meents, DL, and Swain, SL

J Immunol 2006. 177(5): 2888-98


18. 58935 DMID-LS-127; PUBMED-DMID-9/11/2006

Improving anti-hepatitis C virus therapy

Pol, S and Mallet, VO

Expert Opin Biol Ther 2006. 6(9): 923-33


19. 58936 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Synthesis of 2-bromo-6-octylamino-1-b-D-ribofuranosylimidazo[4,5-e][1,3]diazepine-4,8-dione: A Ring-expanded nucleoside analog with a therapeutic promise against Flaviviridae

Zhang, Peng, Zhang, Ning, and Hosmane, Ramachandra S

Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006 2006.: MEDI-231

20. 58937 DMID-LS-127; PUBMED-DMID-9/11/2006

Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses

Yen, HL, Hoffmann, E, Taylor, G, Scholtissek, C, Monto, AS, Webster, RG, and Govorkova, EA

J Virol 2006. 80(17): 8787-95


21. 58938 DMID-LS-127; PUBMED-DMID-9/11/2006

West Nile virus 5'-cap structure is formed by sequential guanine N-7 and ribose 2'-O methylations by nonstructural protein 5

Ray, D, Shah, A, Tilgner, M, Guo, Y, Zhao, Y, Dong, H, Deas, TS, Zhou, Y, Li, H, and Shi, PY

J Virol 2006. 80(17): 8362-70


22. 58939 DMID-LS-127; PUBMED-DMID-9/11/2006

Corneal toxicity of cell-penetrating peptides that inhibit Herpes simplex virus entry

Akkarawongsa, R, Cullinan, AE, Zinkel, A, Clarin, J, and Brandt, CR

J Ocul Pharmacol Ther 2006. 22(4): 279-89


23. 58940 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Anticancer and antiviral activities of organotin polyether amines derived from the antiviral acyclovir

Roner, Michael R, Carraher, Charles E, Sabir, Theodore S, Shahi, Kim, Roehr, Joanne L, and Bassett, Kelly D

Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006 2006.: PMSE-303

24. 58941 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Isoindolylureas a new group of antiviral compounds

Verma, Manjusha and Singh, Krishna Nand

Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006 2006.: MEDI-226

25. 58942 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Pyrroloquinolines as human cytomegalovirus polymerase inhibitors: SAR of arylethanolamine side-chain at C-8

Nair, Sajiv K, Schultz, Brenda L, Nieman, James A, Heasley, Steven E, Vaillancourt, Valerie A, and Brammer, Carolyn A

Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006 2006.: MEDI-224

26. 58943 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use

Monto Arnold S, McKimm-Breschkin Jennifer L, Macken Catherine, Hampson Alan W, Hay Alan, Klimov Alexander, Tashiro Masato, Webster Robert G, Aymard Michelle, Hayden Frederick G, and Zambon Maria

Antimicrobial agents and chemotherapy 2006. 50(7): 2395-402.

27. 58944 DMID-LS-127; WOS-DMID-9/11/2006

Practical Synthesis of 2-(2-Isopropylaminothiazol-4-Yl)-7-Methoxy-1h-Quinolin-4-One: Key Intermediate for the Synthesis of Potent Hcvns3 Protease Inhibitor Biln 2061

Frutos, R. et al.

Synthesis-Stuttgart 2006.(15): 2563-2567


28. 58945 DMID-LS-127; WOS-DMID-9/11/2006

The Structure of the Endoribonuclease Xendou: From Small Nucleolar Rna Processing to Severe Acute Respiratory Syndrome Coronavirus Replication

Renzi, F. et al.

Proceedings of the National Academy of Sciences of the United States of America 2006. 103(33): 12365-12370


29. 58946 DMID-LS-127; WOS-DMID-9/11/2006

Inhibition of Viral Proteases by Zingiberaceae Extracts and Flavones Isolated From Kaempferia Parviflora

Sookkongwaree, K. et al.

Pharmazie 2006. 61(8): 717-721


30. 58947 DMID-LS-127; SCIFINDER-DMID-9/11/2006

8-Azabicyclo[3.2.1]octane derivatives with an activity on chemokine CCR5 receptors and their preparation, pharmaceutical compositions and use for treatment of inflammatory diseases and infection caused by HIV and genetically related retroviruses

Pryde, David Cameron and Stupple, Paul Anthony

PATENT: WO 2006067584 ISSUE DATE: 20060629

APPLICATION: 2005 PP: 67 pp.

ASSIGNEE: (Pfizer Limited, UK

31. 58948 DMID-LS-127; WOS-DMID-9/11/2006

A 5 ' Rna Element Promotes Dengue Virus Rna Synthesis on a Circular Genome

Filomatori, C. et al.

Genes & Development 2006. 20(16): 2238-2249


32. 58949 DMID-LS-127; WOS-DMID-9/11/2006

Bk Virus Infection in Transplant Recipients: an Overview and Update

Randhawa, P. and Brennan, D.

American Journal of Transplantation 2006. 6(9): 2000-2005


33. 58950 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics

Balzarini, Jan, Keyaerts, Els, Vijgen, Leen, Egberink, Herman, De Clercq, Erik, Van Ranst, Marc, Printsevskaya, Svetlana S, Olsufyeva, Eugenia N, Solovieva, Svetlana E, and Preobrazhenskaya, Maria N

Antiviral Research 2006. 72(1): 20-33

34. 58951 DMID-LS-127; WOS-DMID-9/11/2006

Utilization of Ribozymes as Antiviral Agents

Benitez-Hess, M. and Alvarez-Salas, L.

Letters in Drug Design & Discovery 2006. 3(6): 390-404


35. 58952 DMID-LS-127; WOS-DMID-9/11/2006

Antiviral Defense: Interferons and Beyond

Stetson, D. and Medzhitov, R.

Journal of Experimental Medicine 2006. 203(8): 1837-1841


36. 58953 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Antiviral effects of saikosaponins on human coronavirus 229E in vitro

Cheng, Pei-Win, Ng, Lean-Teik, Chiang, Lien-Chai, and Lin, Chun-Ching

Clinical and Experimental Pharmacology and Physiology 2006. 33(7): 612-616

37. 58954 DMID-LS-127; WOS-DMID-9/11/2006

The Anti-Viral Effects of Interferon-Alpha on Varicella-Zoster Virus (Vzv).

Ku, C., Schaap, A., and Arvin, A.

Clinical Immunology 2006. 119: S181


38. 58955 DMID-LS-127; WOS-DMID-9/11/2006

Alkoxyakl Esters of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy)Propyl] Adenine Are Potent Inhibitors of the Replication of Wild-Type and Drug-Resistant Human Immunodeficiency Virus Type 1 in Vitro

Hostetler, K. et al.

Antimicrobial Agents and Chemotherapy 2006. 50(8): 2857-2859


39. 58956 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Furin inhibitors and a-defensins for the treatment or prevention of papillomavirus infection

Day, Patricia M, Richards, Rebecca, Buck, Christopher, Schiller, John T, and Lowy, Douglas R

PATENT: WO 2006084131 ISSUE DATE: 20060810

APPLICATION: 2006 PP: 94pp.

ASSIGNEE: (The Government of the United States of America, As Represented by the Secretary Department of Health and Human Services USA

40. 58957 DMID-LS-127; SCIFINDER-DMID-9/11/2006

Carrageenan is a potent inhibitor of papillomavirus infection

Buck, Christopher B, Thompson, Cynthia D, Roberts, Jeffrey N, Muller, Martin, Lowy, Douglas R, and Schiller, John T

PLoS Pathogens 2006. 2(7): 671-680

41. 58958 DMID-LS-127; WOS-DMID-9/11/2006

Role of T Cells, Cytokines and Antibody in Dengue Fever and Dengue Haemorrhagic Fever

Fink, J., Gu, F., and Vasudevan, S.

Reviews in Medical Virology 2006. 16(4): 263-275


42. 58959 DMID-LS-127; WOS-DMID-9/11/2006

Decision Analysis in Planning for a Polio Outbreak in the United States

Jenkins, P. and Modlin, J.

Pediatrics 2006. 118(2): 611-618


43. 58960 DMID-LS-127; WOS-DMID-9/11/2006

Synthesis of 2-Bromomethyl-3-Hydroxy-2-Hydroxymethyl-Propyl Pyrimidine and Theophylline Nucleosides Under Microwave Irradiation. Evaluation of Their Activity Against Hepatitis B Virus

El Ashry, E. et al.

Nucleosides Nucleotides & Nucleic Acids 2006. 25(8): 925-939


44. 58961 DMID-LS-127; WOS-DMID-9/11/2006

A Nutritional Supplement Formula for Influenza a (H5n1) Infection in Humans

Friel, H. and Lederman, H.

Medical Hypotheses 2006. 67(3): 578-587


45. 58962 DMID-LS-127; WOS-DMID-9/11/2006

The Hcvns3 Protease Inhibitor Sch 503034 in Combination With Peg-Ifn Alpha-2b in the Treatment of Hcv-1peg-Ifn Alpha-2b Non-Responders: Antiviral Activity and Hcv Variant Analysis

Zeuzem, S. et al.

Journal of Hepatology 2006. 44: S35


46. 58963 DMID-LS-127; WOS-DMID-9/11/2006

Telbivudine Displays Consistent Antiviral Efficacy Across Patient Subgroups for the Treatment of Chronic Hepatitis B: Results From the Globe Study

Thongsawat, S. et al.

Journal of Hepatology 2006. 44: S49


47. 58964 DMID-LS-127; WOS-DMID-9/11/2006

Inhibitory Effects of 10-23 Dnazyme on the Expression of Hepatitis B Virus

Ren, N. et al.

Journal of Hepatology 2006. 44: S150


48. 58965 DMID-LS-127; WOS-DMID-9/11/2006

Emergence of Dual-Resistance Hbv Mutations to Adefovir-Dipivoxil and Lamivudine in a Hepatitis B Patient With Combination Therapy for Adefovir Resistance

Kwon, S. et al.

Journal of Hepatology 2006. 44: S273-S274


49. 58966 DMID-LS-127; WOS-DMID-9/11/2006

Is Combination Antiviral Therapy for Cmv Superior to Monotherapy?

Drew, W.

Journal of Clinical Virology 2006. 35(4): 485-488


50. 58967 DMID-LS-127; WOS-DMID-9/11/2006

Early Viral Response to Cpg 10101, a New Investigational Antiviral Tlr9 Agonist, in Combination With Pegylated Interferon and/or Ribavirin, in Prior Relapse Hcv Responders: Preliminary Report of a Randomized Phase 1 Study

Mchutchison, J. et al.

Gastroenterology 2006. 130(4): A784


51. 58968 DMID-LS-127; WOS-DMID-9/11/2006

Exogenous Nitric Oxide Inhibits Crimean Congo Hemorrhagic Fever Virus

Simon, M. et al.

Virus Research 2006. 120(1-2): 184-190


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