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ONLINE DATABASE SEARCH - DMID-LS-131-MEMO

1. 59321 DMID-LS-131; PUBMED-DMID-11/7/2006

Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

Rao, JR, Schinazi, RF, and Chu, CK

Bioorg Med Chem 2006.


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17085053&dopt=abstract


2. 59322 DMID-LS-131; PUBMED-DMID-11/7/2006

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: From anti-pestivirus to anti-hepatitis C virus activity

Puerstinger, G, Paeshuyse, J, De, Clercq E, and Neyts, J

Bioorg Med Chem Lett 2006.


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17084081&dopt=abstract


3. 59323 DMID-LS-131; PUBMED-DMID-11/7/2006

Fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-2-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine

Manta, S, Agelis, G, Botic, T, Cencic, A, and Komiotis, D

Bioorg Med Chem 2006.


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17079149&dopt=abstract


4. 59324 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Antiviral drug combinations using a glycosylation modulator and a membrane fusion inhibitor

Nash, Robert James, Slingsby, Jason H, and Carroll, Miles William

PATENT: WO 2006077427 ISSUE DATE: 20060727

APPLICATION: 2006 PP: 85 pp.

ASSIGNEE: (MNL Pharma Limited, UK


5. 59325 DMID-LS-131; PUBMED-DMID-11/7/2006

New therapeutic options for hepatitis C

Waters, L and Nelson, M

Curr Opin Infect Dis 2006. 19(6): 615-22


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17075339&dopt=abstract



6. 59326 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Thienyl compounds for treating virus-related conditions

Olivo, Paul D, Buscher, Benjamin A, Dyall, Julie, Jockel-Balsarotti, Jennifer I, O'Guin, Andrew K, Roth, Robert M, Franklin, Gary W, and Starkey, Gale W

PATENT: WO 2006093518 ISSUE DATE: 20060908

APPLICATION: 2005 PP: 343pp.

ASSIGNEE: (Apath, LLC USA


7. 59327 DMID-LS-131; PUBMED-DMID-11/7/2006

Activities of oseltamivir and ribavirin used alone and in combination against infections in mice with recent isolates of influenza A (H1N1) and B viruses

Smee, DF, Wong, MH, Bailey, KW, and Sidwell, RW

Antivir Chem Chemother 2006. 17(4): 185-192


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17066897&dopt=abstract


8. 59328 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Inhibitors of enveloped virus infectivity

Cunningham, James and Chandran, Kartik

PATENT: WO 2006091610 ISSUE DATE: 20060831

APPLICATION: 2006 PP: 65pp.

ASSIGNEE: (The Brigham and Women's Hospital, Inc. USA


9. 59329 DMID-LS-131; PUBMED-DMID-11/7/2006

Peptide Inhibitors of West Nile NS3 Protease: SAR Study of Tetrapeptide Aldehyde Inhibitors

Knox, JE, Ma, NL, Yin, Z, Patel, SJ, Wang, WL, Chan, WL, Ranga, Rao KR, Wang, G, Ngew, X, Patel, V, Beer, D, Lim, SP, Vasudevan, SG, and Keller, TH

J Med Chem 2006. 49(22): 6585-90


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17064076&dopt=abstract


10. 59330 DMID-LS-131; PUBMED-DMID-11/7/2006

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design

El Omari, K, Solaroli, N, Karlsson, A, Balzarini, J, and Stammers, DK

BMC Struct Biol 2006. 6(1): 22


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17062140&dopt=abstract



11. 59331 DMID-LS-131; PUBMED-DMID-11/7/2006

Antiviral activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of inosine monophosphate dehydrogenase

Sun, Y, Chung, DH, Chu, YK, Jonsson, CB, and Parker, WB

Antimicrob Agents Chemother 2006.


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17060520&dopt=abstract


12. 59332 DMID-LS-131; PUBMED-DMID-11/7/2006

Synthesis and antiviral activity against tobacco mosaic virus and 3D-QSAR of alpha-substituted-1,2,3-thiadiazoleacetamides

Zhao, WG, Wang, JG, Li, ZM, and Yang, Z

Bioorg Med Chem Lett 2006.


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17055269&dopt=abstract


13. 59333 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Preparation of tricyclic nucleoside prodrugs for treating viral infections

Keicher, Jesse Daniel and Roberts, Christopher Don

PATENT: US 2006194749 ISSUE DATE: 20060831

APPLICATION: 2006-37490 PP: 63pp.

ASSIGNEE: (Genelabs Technologies, Inc. USA


14. 59334 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Preparation of heteroarylindolecarboxylates as antivirals

Botyanszki, Janos, Roberts, Christopher Don, Schmitz, Franz Ulrich, Gralapp, Joshua Michael, Griffith, Ronald Conrad, Shi, Dong-Fang, Leivers, Martin Robert, and Brewster, Rachel Elizabeth

PATENT: WO 2006076529 ISSUE DATE: 20060720

APPLICATION: 2006 PP: 203 pp.

ASSIGNEE: (Genelabs Technologies, Inc. USA


15. 59335 DMID-LS-131; WOS-DMID-11/7/2006

Potent Inhibition of Human Hepatitis B Virus Replication by a Host Factor Vps4

Chua, P., Lin, M., and Shih, C.

Virology 2006. 354(1): 1-6


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000241178500001


16. 59336 DMID-LS-131; PUBMED-DMID-11/7/2006

Comparison of the inhibitory effects of interferon alfacon-1 and ribavirin on yellow fever virus infection in a hamster model

Julander, JG, Morrey, JD, Blatt, LM, Shafer, K, and Sidwell, RW

Antiviral Res 2006.


HYPERLINK:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17049380&dopt=abstract


17. 59337 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Diketo acids on nucleobase scaffolds as inhibitors of Flaviviridae

Nair, Vasu, Chi, Guochen, and Uchil, Vinod R

PATENT: US 2006223834 ISSUE DATE: 20061005

APPLICATION: 2005-32589 PP: 36pp.

ASSIGNEE: (USA)


18. 59338 DMID-LS-131; WOS-DMID-11/7/2006

Substituted 5-Benzyl-2-Phenyl-5h-Imidazo[4,5-C]Pyridines: a New Class of Pestivirus Inhibitors

Puerstinger, G. et al.

Bioorganic & Medicinal Chemistry Letters 2006. 16(20): 5345-5349


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000241344400019


19. 59339 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Medicine composition containing thymopentin and interferon as antiviral and antitumor agents

Wang, Shujuan, Jia, Zhidan, Piao, Zhisong, and Wang, Zhenguo

PATENT: CN 1833721 ISSUE DATE: 20060920

APPLICATION: 1007-6271 PP: 8pp.

ASSIGNEE: (Beijing Guodan Medicine Technological Development Co., Ltd. Peop. Rep. China and Jilin Yixin Pharmaceutical Co., Ltd.


20. 59340 DMID-LS-131; WOS-DMID-11/7/2006

Structure-Guided Design of a Novel Class of Benzyl-Sulfonate Inhibitors for Influenza Virus Neuraminidase

Platis, D. et al.

Biochemical Journal 2006. 399: 215-223


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000241348600005


21. 59341 DMID-LS-131; WOS-DMID-11/7/2006

A Simple and Efficient Synthesis of 2-Deoxy-L-Ribose From 2-Deoxy-D-Ribose

Ji, Q. et al.

Synlett 2006.(15): 2498-2500


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000241175500034


22. 59342 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Drug compositions containing tetrahydro-2H-thiopyran-4-carboxamide derivatives, and anti-herpesvirus agent containing the same

Kontani, Toru, Miyata, Junji, Hamaguchi, Wataru, Kamikawa, Akio, Kono, Tomoaki, Suzuki, Hiroshi, and Sudo, Kenji

PATENT: JP 2006241144 ISSUE DATE: 20060914

APPLICATION: 2006-24024 PP: 21pp.

ASSIGNEE: (Astellas Pharma Inc., Japan and Soyaku Gijutsu Kenkyusho K. K.)



23. 59343 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Curative-prophylactic pomade eliciting antiviral activity

Prokop'eva, LA, Vinogradov, AK, Kungurtseva, NV, Lesnykh, OA, Mitrofanova, EG, and Gavinskii, YuV

PATENT: RU 2282473 ISSUE DATE: 20060827

APPLICATION: 2002-37587 PP: 9pp.

ASSIGNEE: (ZAO \"Evalar\", Russia


24. 59344 DMID-LS-131; WOS-DMID-11/7/2006

Synthesis of Trifluoromethyl Ketone-Containing Glutamic Acid and Glutamine Peptides as Severe Acute Respiratory Syndrome Coronavirus 3cl Protease Inhibitors

Sydnes, M. et al.

Journal of Peptide Science 2006. 12: 109


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000239905600102


25. 59345 DMID-LS-131; WOS-DMID-11/7/2006

An Efficient Method for the Synthesis of Peptide Aldehyde Libraries Employed in the Discovery of Sars Corona Virus Main Protease Inhibitors

Schmidt, M. et al.

Journal of Peptide Science 2006. 12: 168


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000239905600337


26. 59346 DMID-LS-131; WOS-DMID-11/7/2006

Picornaviral 3cp Inhibitors. Multiple-Peptide Synthesis in Parallel and Biological Evaluation

Minchev, I. et al.

Journal of Peptide Science 2006. 12: 217


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000239905600531


27. 59347 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Anti-alpha-herpesvirus drugs

Coen, Donald M

Alpha Herpesviruses 2006.: 361-381


28. 59348 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Pharmaceutical preparation of N -[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl] acetamide for use as antiviral agent

Laich, Tobias and Liebelt, Katrin

PATENT: WO 2006103011 ISSUE DATE: 20061005

APPLICATION: 2006 PP: 25pp.

ASSIGNEE: (Aicuris G.m.b.H. & Co. K.-G., Germany


29. 59349 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Method of screening for inhibitors of IRES-mediated translation and identification of antiviral peptides targeted to hepatitis C virus

Fear, Mark

PATENT: WO 2006102720 ISSUE DATE: 20061005

APPLICATION: 2006 PP: 197pp.

ASSIGNEE: (Telethon Institute for Child Health Research, Australia


30. 59350 DMID-LS-131; WOS-DMID-11/7/2006

Effects of Cidofovir Treatment on Cytokine Induction in Murine Models of Cowpox and Vaccinia Virus Infection

Knorr, C. et al.

Antiviral Research 2006. 72(2): 125-133


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000241092900006


31. 59351 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Influenza virus NS1 protein protects against lymphohematopoietic pathogenesis in an in vivo mouse model

Hyland Lisa, Webby Richard, Sandbulte Matthew R, Clarke Ben, and Hou Sam

Virology 2006. 349(1): 156-163


32. 59352 DMID-LS-131; WOS-DMID-11/7/2006

Antiviral-Resistant Hbv: Can We Prevent This Monster From Growing?

Lok, A.

Journal of Clinical Virology 2006. 36: S22


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000239067300066


33. 59353 DMID-LS-131; WOS-DMID-11/7/2006

New Hcv Antiviral Therapies

Zeuzem, S.

Journal of Clinical Virology 2006. 36: S49-S50


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000239067300143


34. 59354 DMID-LS-131; WOS-DMID-11/7/2006

A Cell-Based Assay for Evaluating Potential Antiviral Agents Against Hcv

Aviel, S. et al.

Journal of Clinical Virology 2006. 36: S116


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000239067300350


35. 59355 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Dithiocarbamate antiviral compounds for production of an agent for the treatment or prevention of a viral infection in the respiratory tract, and for a disinfecting agent

Gaudernak, Elisabeth, Grassauer, Andreas, Kuchler, Ernst, Muster, Thomas, and Seipelt, Joachim

PATENT: WO 2003007935 ISSUE DATE: 20030130

APPLICATION: 2002 PP: 50 pp.

ASSIGNEE: (Austria)


36. 59356 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses: Design, Synthesis, and Biological Evaluation

Hamdouchi, Chafiq, Sanchez-Martinez, Concha, Gruber, Joseph, del Prado, Miriam, Lopez, Javier, Rubio, Almudena, and Heinz, Beverly A

Journal of Medicinal Chemistry 2003. 46(20): 4333-4341



37. 59357 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Preparation of 1,1-dioxodihydrobenzothiadiazines as antiviral agents

Darcy, Michael G, Dhanak, Dashyant, Duffy, Kevin J, Fitch, Duke M, Sarisky, Robert T, Shaw, Antony N, Tedesco, Rosanna, and Zimmerman, Michael N

PATENT: WO 2003059356 ISSUE DATE: 20030724

APPLICATION: 2002 PP: 103 pp.

ASSIGNEE: (Smithkline Beecham Corporation, USA


38. 59358 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Preparation of oxadiazolylphenoxyalkylisoxazoles as anti-picornaviral agents

Rhodes, Gerald and Nitz, Theodore J

PATENT: WO 2003020271 ISSUE DATE: 20030313

APPLICATION: 2002 PP: 37 pp.

ASSIGNEE: (Viropharma Incorporated, USA


39. 59359 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Preparation of dioxolane and oxathiolane nucleosides as antivirals and inhibitors of RNA-dependent RNA viral polymerase

Carroll, Steven S, MacCoss, Malcolm, Kuo, Lawrence C, Olsen, David B, Bhat, Balkrishen, Eldrup, Anne Bettina, Prhavc, Marija, Malik, Leila, and Bera, Sanjib

PATENT: WO 2003020222 ISSUE DATE: 20030313

APPLICATION: 2002 PP: 82 pp.

ASSIGNEE: (Merck & Co., Inc. USA and Isis Pharmaceuticals, Inc.


40. 59360 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Preparation of 6-[2-(1-pyridazinyl-4-piperidinyl)ethoxy]benzoxazoles and analogs as antiviral agents

Keith, Watson, Krippner, Guy, Stanislawski, Pauline, and McConnell, Darryl

PATENT: WO 2002050045 ISSUE DATE: 20020627

APPLICATION: 2001 PP: 76 pp.

ASSIGNEE: (Biota Scientific Management Pty Ltd., Australia


41. 59361 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections

Wang, QMay

Antiviral Agents 2001.: 229-253


42. 59362 DMID-LS-131; SCIFINDER-DMID-11/7/2006

In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus

Semple, Susan J, Pyke, Simon M, Reynolds, Geoffrey D, and Flower, Robert LP

Antiviral Research 2001. 49(3): 169-178


43. 59363 DMID-LS-131; SCIFINDER-DMID-11/7/2006

1,2-Disubstituted 1,4-dihydro-4-oxoquinoline compounds and their antiviral activity

Tamura, Takashi, Kuriyama, Haruo, Agoh, Masanobu, Agoh, Yumi, Soga, Manabu, and Mori, Teruyo

PATENT: EP 1081138 ISSUE DATE: 20010307

APPLICATION: 2000-53137 PP: 64 pp.

ASSIGNEE: (Maruishi Pharmaceutical Co., Ltd. Japan



44. 59364 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Preparation of (heterocyclyl)alkoxy benzaldehyde oximes as antiviral agents

Wu, Wen-Yang, Watson, Keith, Mcconnell, Darryl, Jin, Betty, and Krippner, Guy

PATENT: WO 2000078746 ISSUE DATE: 20001228

APPLICATION: 2000 PP: 84 pp.

ASSIGNEE: (Biota Scientific Management Pty. Ltd., Australia


45. 59365 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Anti-rhinovirus activity of 3-methylthio-5-aryl-4-isothiazolecarbonitrile derivatives

Garozzo, A, Cutri, CCC, Castro, A, Tempera, G, Guerrera, F, Sarva, MC, and Geremia, E

Antiviral Research 2000. 45(3): 199-210


46. 59366 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Anti-viral imidazo[1,2-a]pyridine derivatives and their pharmaceutical formulations and use

Ezquerra-Carrera, Jesus, Gruber, Joseph Michael, Hamdouchi, Chafiq Hamdouchi, Holmes, Richard Elmer, and Spitzer, Wayne Alfred

PATENT: WO 9959587 ISSUE DATE: 19991125

APPLICATION: 98 PP: 138 pp.

ASSIGNEE: (Eli Lilly and Company, USA


47. 59367 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

Matthews, DA, Dragovich, PS, Webber, SE, Fuhrman, SA, Patick, AK, Zalman, LS, Hendrickson, TF, Love, RA, Prins, TJ, Marakovits, JT, Zhou, R, Tikhe, J, Ford, CE, Meador, JW, Ferre, RA, Brown, EL, Binford, SL, Brothers, MA, Delisle, DM, and Worland, ST

Proceedings of the National Academy of Sciences of the United States of America 1999. 96(20): 11000-11007


48. 59368 DMID-LS-131; SCIFINDER-DMID-11/7/2006

In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease

Patick, AK, Binford, SL, Brothers, MA, Jackson, RL, Ford, CE, Diem, MD, Maldonado, F, Dragovich, PS, Zhou, R, Prins, TJ, Fuhrman, SA, Meador, JW, Zalman, LS, Matthews, DA, and Worland, ST

Antimicrobial Agents and Chemotherapy 1999. 43(10): 2444-2450


49. 59369 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Anti-picornavirus activity of synthetic flavon-3-yl esters

Conti, C, Mastromarino, P, Sgro, R, and Desideri, N

Antiviral Chemistry & Chemotherapy 1998. 9(6): 511-515


50. 59370 DMID-LS-131; WOS-DMID-11/7/2006

E7 Proteins From High- and Low-Risk Human Papillomaviruses Bind to Tgf-Beta-Regulated Smad Proteins and Inhibit Their Transcriptional Activity

Habig, M. et al.

Archives of Virology 2006. 151(10): 1961-1972


HYPERLINK:

http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000240723300005



51. 59371 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Synthesis and in vitro evaluation of the anti-viral activity of N-[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl]alkylcarboxamides

Carta, Antonio, Loriga, Giovanni, Piras, Sandra, Paglietti, Giuseppe, Ferrone, Marco, Fermeglia, Maurizio, Pricl, Sabrina, La Colla, Paolo, Secci, Barbara, Collu, Gabriella, and Loddo, Roberta

Medicinal Chemistry 2006. 2(6): 577-589


52. 59372 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Application of quercetin-3-b-galactoside in medicine for inhibiting replication of SARS coronavirus and common cold virus HCoV-229E

Zhu, Weiliang, Pan, Chunmu, Chen, Lili, Shen, Xu, Chen, Gang, Luo, Cheng, Xu, Weijun, Luo, Xiaomin, Liu, Hong, Shen, Jianhua, Chen, Kaixian, and Jiang, Hualiang

PATENT: CN 1830449 ISSUE DATE: 20060913

APPLICATION: 1002-4349 PP: 12pp.

ASSIGNEE: (Shanghai Institute of Materia Medica, Chinese Academy of Sciences Peop. Rep. China and Singapore Polytechnic)


53. 59373 DMID-LS-131; SCIFINDER-DMID-11/7/2006

High and low risk human papillomaviruses: disease links, biology, immunology and vaccine development

Brinkman, Joeli A, Fahey, Laura M, Kast, Dieuwertje J, Da Silva, Diane M, and Kast, WMartin

Viral Oncogenesis 2006.: 75-105


54. 59374 DMID-LS-131; SCIFINDER-DMID-11/7/2006

Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-4-yl-amines as janus kinase inhibitors and their preparation, pharmaceutical compositions and use for treatment of diseases

Rodgers, James D, Wang, Heisheng, Combs, Andrew P, and Sparks, Richard B

PATENT: WO 2006069080 ISSUE DATE: 20060629

APPLICATION: 2005 PP: 86 pp.

ASSIGNEE: (Incyte Corporation, USA


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