ONLINE DATABASE SEARCH - DMID-LS-83-MEMO
1. 56003 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action
Rossi, Shannan L, Zhao, Qizu, O'Donnell, Vivian K, and Mason, Peter W
Virology 2005. 331(2): 457-470
2. 56004 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Evolution and Variation of the SARS-CoV Genome
Hu, J, Wang, J, Xu, J, Li, W, Han, Y, Li, Y, Ji, J, Ye, J, Xu, Z, Zhang, Z, Wei, W, Li, S, Wang, J, Wang, J, Yu, J, and Yang, H
Genomics Proteomics Bioinformatics 2003. 1(3): 216-25
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15629034&dopt=abstract
3. 56005 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
FK778, A Synthetic Malononitrilamide
Fitzsimmons, WE and First, MR
Yonsei Med J 2004. 45(6): 1132-5
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15627308&dopt=abstract
4. 56006 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Suppression of hepatitis C virus replicon by TGF-b
Murata, Takayuki, Ohshima, Takayuki, Yamaji, Masashi, Hosaka, Masahiro, Miyanari, Yusuke, Hijikata, Makoto, and Shimotohno, Kunitada
Virology 2005. 331(2): 407-417
5. 56007 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Inhibitory properties of nucleic acid-binding ligands on protein synthesis
Malina, A, Khan, S, Carlson, CB, Svitkin, Y, Harvey, I, Sonenberg, N, Beal, PA, and Pelletier, J
FEBS Lett 2005. 579(1): 79-89
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15620694&dopt=abstract
6. 56008 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
A strategy for obtaining near full-length HCV cDNA clones (assemblicons) by assembly PCR
Sheehy, P, Scallan, M, Kenny-Walsh, E, Shanahan, F, and Fanning, LJ
Journal of Virological Methods 2005. 123(2): 115-124
7. 56009 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Albuferon (Tm) - a Novel Therapeutic Agent for Hepatitis C: Results of a Phase 1/2 Study in Treatment Experienced Subjects With Chronic Hepatitis C
Balan, V. et al.
Hepatology 2004. 40(4): 280A-281A
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224102100267
8. 56010 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Expression of Hcv Protease in the Liver of Mice Results in Liver Injury Which Can Be Inhibited by Vx-950, a Vertex Hcv Protease Inhibitor
Kalkeri, G. et al.
Hepatology 2004. 40(4): 281A
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224102100268
9. 56011 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Inhibition of respiratory viruses by nasally administered siRNA
Bitko, V, Musiyenko, A, Shulyayeva, O, and Barik, S
Nat Med 2004.
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15619632&dopt=abstract
10. 56012 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene
Zhang, W, Yang, H, Kong, X, Mohapatra, S, Juan-Vergara, HS, Hellermann, G, Behera, S, Singam, R, Lockey, RF, and Mohapatra, SS
Nat Med 2004.
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15619625&dopt=abstract
11. 56013 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
In Vitro Anti-Viral Effects of Interferon and Ribavirin at Their Clinical Concentrations Against Hepatitis C Virus.
Kato, T. et al.
Hepatology 2004. 40(4): 321A
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224102100366
12. 56014 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Impact of mycophenolate mofetil versus azathioprine on early recurrence of hepatitis C after liver transplantation
Kornberg, A, Kuepper, B, Tannapfel, A, Hommann, M, and Scheele, J
International Immunopharmacology 2005. 5(1): 107-115
13. 56015 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a New Class of Methylenecyclopropane Analogues of Nucleosides: Synthesis and Antiviral Activity(1)
Zhou, S, Kern, ER, Gullen, E, Cheng, YC, Drach, JC, Matsumi, S, Mitsuya, H, and Zemlicka, J
J Med Chem 2004. 47(27): 6964-6972
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15615545&dopt=abstract
14. 56016 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
A Phase Ii, Randomized Trial Evaluating the Safety, Pharmacokinetics and Antiviral Activity of Clevudine for 12 Weeks in Patients With Chronic Hepatitis B
Marcellin, P. et al.
Hepatology 2004. 40(4): 652A
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224102101131
15. 56017 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Non-Nucleoside Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus NS5B Polymerase: Inhibition of Subgenomic Hepatitis C Virus RNA Replicons in Huh-7 Cells
Beaulieu, PL, Bousquet, Y, Gauthier, J, Gillard, J, Marquis, M, McKercher, G, Pellerin, C, Valois, S, and Kukolj, G
J Med Chem 2004. 47(27): 6884-92
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15615537&dopt=abstract
16. 56018 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
N-1-Aza-4-Hydroxyquinolone Benzothiadiazines: Inhibitors of Hcv Genotype 1 Ns5b Rna-Dependent Rna Polymerase Exhibiting Replicon Potency and Favorable Rat Pharmacokinetics.
Pratt, J. et al.
Hepatology 2004. 40(4): 697A
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224102101227
17. 56019 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Final Phase I/Ii Trial Results for Nm283, a New Polymerase Inhibitor for Hepatitis C: Antiviral Efficacy and Tolerance in Patients With Hcv-1 Infection, Including Previous Interferon Failures
Afdhal, N. et al.
Hepatology 2004. 40(4): 726A
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224102101292
18. 56020 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Sensitivity of Hepatitis C Virus Rna to the Antiviral Enzyme Ribonuclease L Is Determined by a Subset of Efficient Cleavage Sites
Han, J. et al.
Journal of Interferon and Cytokine Research 2004. 24(11): 664-676
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000225268900005
19. 56021 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Hcv Infective Virions Can Be Carried by Human Platelets
Pugliese, A. et al.
Cell Biochemistry and Function 2004. 22(6): 353-358
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000225253500002
20. 56022 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
The pneumonia virus of mice infection model for severe respiratory syncytial virus infection: identifying novel targets for therapeutic intervention
Rosenberg, Helene F, Bonville, Cynthia A, Easton, Andrew J, and Domachowske, Joseph B
Pharmacology & Therapeutics 2005. 105(1): 1-6
21. 56023 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Receptor modulation in viral replication: HIV, HSV, HHV-8 and HPV: same goal, different techniques to interfere with MHC-I antigen presentation
Piguet, V
Curr Top Microbiol Immunol 2005. 285: 199-217
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15609505&dopt=abstract
22. 56024 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
The management of chronic viral hepatitis: A Canadian consensus conference 2004
Sherman, M, Bain, V, Villeneuve, JP, Myers, RP, Cooper, C, Martin, S, and Lowe, C
Can J Gastroenterol 2004. 18(12): 715-28
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15605136&dopt=abstract
23. 56025 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives
Cheng, Jun, Xie, Jiangtao, and Luo, Xianjin
Bioorganic & Medicinal Chemistry Letters 2005. 15(2): 267-269
24. 56026 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Studies on Acyclovir-Dextran Conjugate: Synthesis and Pharmacokinetics
Tu, J., Zhong, S., and Li, P.
Drug Development and Industrial Pharmacy 2004. 30(9): 959-965
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224989700006
25. 56027 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Modulation of drug metabolism and antiviral therapies
Lauterburg, Bernhard H 2005.: 233-251
26. 56028 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus
Bergeron, E, Vincent, MJ, Wickham, L, Hamelin, J, Basak, A, Nichol, ST, Chretien, M, and Seidah, NG
Biochem Biophys Res Commun 2005. 326(3): 554-63
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15596135&dopt=abstract
27. 56029 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Development of an Efficient and Scalable Process of a Respiratory Syncytial Virus Inhibitor
Provencal, D. et al.
Organic Process Research & Development 2004. 8(6): 903-908
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000225340900013
28. 56030 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Mode of selection and experimental evolution of antiviral drugs resistance in vesicular stomatitis virus
Cuevas, Jose M, Sanjuan, Rafael, Moya, Andres, and Elena, Santiago F
Infection, Genetics and Evolution 2005. 5(1): 55-65
29. 56031 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Therapeutic effects of dengue 2 virus capsid protein and staphylococcal nuclease fusion protein on dengue-infected cell cultures
Qin, CF, Qin, E, Yu, M, Chen, SP, Jiang, T, Deng, YQ, Duan, HY, and Zhao, H
Arch Virol 2004.
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15592886&dopt=abstract
30. 56032 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Ribavirin and interferon-b synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines
Morgenstern, Birgit, Michaelis, Martin, Baer, Patrick C, Doerr, Hans W, and Cinatl, Jindrich
Biochemical and Biophysical Research Communications 2005. 326(4): 905-908
31. 56033 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Pharmacokinetics and Pharmacodynamics of Pegylated Interferon Alfa-2a or Alfa-2b With Ribavirin in Treatment Naive Patients With Genotype 1 Chronic Hepatitis C
Di Bisceglie, A. et al.
Hepatology 2004. 40(4): 734A
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224102101307
32. 56034 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Quaternary Structure of the Severe Acute Respiratory Syndrome (Sars) Coronavirus Main Protease
Chou, C. et al.
Biochemistry 2004. 43(47): 14958-14970
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000225353300010
33. 56035 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Picornavirus IRES: structure function relationship
Martinez-Salas, E and Fernandez-Miragall, O
Curr Pharm Des 2004. 10(30): 3757-67
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15579069&dopt=abstract
34. 56036 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Preparation of phenylacetamides and phenyl ureas as inhibitors of papilloma virus
Tsantrizos, Youla S, Faucher, Anne-Marie, Rancourt, Jean, and White, Peter
PATENT: WO 2004108673 ISSUE DATE: 20041216
APPLICATION: 2004 PP: 80 pp.
ASSIGNEE: (Boehringer Ingelheim International G.m.b.H., Germany and Boehringer Ingelheim Pharma G.m.b.H. & Co. K.-G.)
35. 56037 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Herpes simplex virus type 1 amplicons and their hybrid virus partners, EBV, AAV, and retrovirus
Oehmig, A, Fraefel, C, Breakefield, XO, and Ackermann, M
Curr Gene Ther 2004. 4(4): 385-408
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15578989&dopt=abstract
36. 56038 DMID-LS-83; PUBMED-DMID-1/5/2005 ; DMID-LSLOAD
Recent advances in rhinovirus therapeutics
Charles, CH, Yelmene, M, and Luo, GX
Curr Drug Targets Infect Disord 2004. 4(4): 331-7
HYPERLINK:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15578974&dopt=abstract
37. 56039 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Preparation of heterocyclic peptides as hepatitis C inhibitors
Llinas-Brunet, Montse
PATENT: US 2004229818 ISSUE DATE: 20041118
APPLICATION: 2004-5555 PP: 42 pp.
ASSIGNEE: (Boehringer Ingelheim International Gmbh, Germany
38. 56040 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Tri-peptide hepatitis c serine protease inhibitors
Miao, Zhenwei, Sun, Ying, Nakajima, Suanne, Tang, Datong, Wang, Zhe, and Or, Yat Sun
PATENT: WO 2004113365 ISSUE DATE: 20041229
APPLICATION: 2004 PP: 84 pp.
ASSIGNEE: (Enanta Pharmaceuticals, Inc. USA
39. 56041 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Hepatitis c virus inhibitors
Lim, Jae-Hong, Yoon, Joo-Yong, Song, Jeong-Uk, Sung, Lee-Taek, Choi, Sung-Pil, Song, Ho-Young, Kim, Jong-Yup, Kim, Yong-Zu, Cho, Young-Gyu, Kim, Chang-Myung, Kim, Won-Sup, Kang, Seung-Wan, and Park, Ji-Hyun
PATENT: WO 2004111013 ISSUE DATE: 20041223
APPLICATION: 2004 PP: 147 pp.
ASSIGNEE: (LG Life Sciences Ltd., S. Korea
40. 56042 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Pyridine n-oxides as antiviral agents
Colarusso, Stefania and Narjes, Frank
PATENT: WO 2004110442 ISSUE DATE: 20041223
APPLICATION: 2004 PP: 36 pp.
ASSIGNEE: (Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A., Italy
41. 56043 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Preparation of [(morpholino)ethylamino]pyridine derivatives as antiviral agents
Kim, Jong-Woo, Lee, Sang-Wook, Lee, Geun-Hyung, Han, Jae-Jin, Park, Sang-Jin, Park, Eul-Yong, and Shin, Joong-Chul
PATENT: WO 2004108719 ISSUE DATE: 20041216
APPLICATION: 2004 PP: 23 pp.
ASSIGNEE: (B & C Biopharm Co., Ltd. S. Korea
42. 56044 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Preparation of substituted imidazole derivatives as antiviral agents
Roberts, Christopher Don, Shi, Dong-Fang, and Griffith, Ronald Conrad
PATENT: WO 2004108687 ISSUE DATE: 20041216
APPLICATION: 2004 PP: 54 pp.
ASSIGNEE: (Genelabs Technologies, Inc. USA
43. 56045 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Conventional Protein Kinase C Inhibition Prevents Alpha Interferon-Mediated Hepatitis C Virus Replicon Clearance by Impairing Stat Activation
Fimia, G. et al.
Journal of Virology 2004. 78(23): 12809-12816
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000225087500009
44. 56046 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Anti-viral activity of cationic peptides of the cathelicidin family including LL-37, homologs and variants thereof, and diagnosing atopic dermatitis by detecting LL-37 or its gene
Gallo, Richard L, Leung, Donald YM, and Jones, James F
PATENT: WO 2004098536 ISSUE DATE: 20041118
APPLICATION: 2004 PP: 55 pp.
ASSIGNEE: (The Regents of the University of California, USA and National Jewish Medical and Research Center)
45. 56047 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Induction of gene mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue
Suter, Willi, Plappert-Helbig, Ulla, Glowienke, Susanne, Poetter-Locher, Franziska, Staedtler, Frank, Racine, Robert, and Martus, Hans-Joerg
Mutation Research 2004. 568(2): 195-209
46. 56048 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Tyrosine Dephosphorylation of Stat3 in Sars Coronavirus-Infected Vero E6 Cells
Mizutani, T. et al.
Febs Letters 2004. 577(1-2): 187-192
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000225128600032
47. 56049 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Synthesis of certain 6-(arylthio)uracils and related derivatives as potential antiviral agents
El-Emam, Ali A, Massoud, Mohamed AM, El-Bendary, Eman R, and El-Sayed, Magda A
Bulletin of the Korean Chemical Society 2004. 25(7): 991-996
48. 56050 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Preparation of thienopyridine-ethanolamine derivatives as antiviral agents
Schnute, Mark E, Cudahy, Michele M, Eggen, Marijean, Anderson, David J, Judge, Thomas M, Kim, Euibong J, and Collier, Sarah A
PATENT: WO 2004106345 ISSUE DATE: 20041209
APPLICATION: 2003 PP: 95 pp.
ASSIGNEE: (Pharmacia & Upjohn Company, USA
49. 56051 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Preparation of cytidine nucleoside analogs as antiviral agents
Girardet, Jean-Luc, Koh, Yung-Hyo, An, Haoyun, and Hong, Zhi
PATENT: WO 2004080466 ISSUE DATE: 20040923
APPLICATION: 2003 PP: 59 pp.
ASSIGNEE: (Ribapharm Inc., USA
50. 56052 DMID-LS-83; WOS-DMID-1/5/2005 ; DMID-LSLOAD
Potent and Selective Inhibition of Sars Coronavirus Replication by Aurintricarboxylic Acid (Vol 320, Pg 1199, 2004)
Adonov, A. et al.
Biochemical and Biophysical Research Communications 2004. 324(3): 1152-1153
HYPERLINK:
http://publishorperish.nih.gov/Gateway.cgi?KeyUT=000224807800030
51. 56053 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Anti-influenza virus compounds comprising biflavonoid-sialic acid glycoside
Yamada, Haruki, Nagai, Takayuki, and Takahashi, Kunio
PATENT: WO 2004076471 ISSUE DATE: 20040910
APPLICATION: 2003 PP: 81 pp.
ASSIGNEE: (The Kitasato Institute, Japan
52. 56054 DMID-LS-83; SCIFINDER-DMID-1/5/2005 ; DMID-LSLOAD
Cromoglycic acid and its salts as antiviral agents for prevention and treatment of influenza
Hiroi, Jun, Tsujii, Eisaku, Suzuki, Yasuo, Hidari, Ippachi, and Miyatake, Akihiko
PATENT: JP 2004352712 ISSUE DATE: 20041216
APPLICATION: 2004-6194 PP: 11 pp.
ASSIGNEE: (Fujisawa Pharmaceutical Co., Ltd. Japan