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1. 56178 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Evaluation of Some Pyrazoloquinolines as Inhibitors of Herpes Simplex Virus Type 1 Replication

Bekhit, AA, El-Sayed, OA, Aboul-Enein, HY, Siddiqui, YM, and Al-Ahdal, MN

Arch Pharm (Weinheim) 2005.


2. 56179 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses

Fouchier, RA, Rimmelzwaan, GF, Kuiken, T, and Osterhaus, AD

Curr Opin Infect Dis 2005. 18(2): 141-146


3. 56180 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

A preparation of heterocyclic compounds, useful for the treatment of diseases associated with TNF-a, IL-1b, IL-6, and COX-1/COX-2

Dominguez, Celia, Harvey, Timothy Scot, Liu, Longbin, and Siegmund, Aaron

PATENT: US 2005020592 ISSUE DATE: 20050127

APPLICATION: 2004-45916 PP: 28 pp.

ASSIGNEE: (Amgen Inc., USA

4. 56181 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Architecture of Replication Compartments Formed during Epstein-Barr Virus Lytic Replication

Daikoku, T, Kudoh, A, Fujita, M, Sugaya, Y, Isomura, H, Shirata, N, and Tsurumi, T

J Virol 2005 . 79(6): 3409-3418


5. 56182 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Synthesis and Anti-Hcmv Activity of Novel 2 ',3 ',4 '-Trimethyl Branched Carbocyclic Nucleosides

Kim, A. and Hong, J.

Nucleosides Nucleotides & Nucleic Acids 2005. 24(1): 63-72


6. 56183 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Inhibitory effect of cyclosporine A on hepatitis B virus replication in vitro and its possible mechanisms

Xia, WL, Shen, Y, and Zheng, SS

Hepatobiliary Pancreat Dis Int 2005. 4(1): 18-22


7. 56184 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Screening of inhibitors for influenza A virus using high-performance affinity chromatography and combinatorial peptide libraries

Zhao, R, Fanga, C, Yu, X, Liu, Y, Luo, J, Shangguan, D, Xiong, S, Su, T, and Liu, G

J Chromatogr A 2005. 1064(1): 59-66


8. 56185 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Efficacy and Toxicity of Zinc Salts as Candidate Topical Microbicides against Vaginal Herpes Simplex Virus Type 2 Infection

Bourne, N, Stegall, R, Montano, R, Meador, M, Stanberry, LR, and Milligan, GN

Antimicrob Agents Chemother 2005. 49(3): 1181-1183


9. 56186 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities

Ying, C, Holy, A, Hockova, D, Havlas, Z, De Clercq, E, and Neyts, J

Antimicrob Agents Chemother 2005. 49(3): 1177-1180


10. 56187 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication

Kern, ER, Kushner, NL, Hartline, CB, Williams-Aziz, SL, Harden, EA, Zhou, S, Zemlicka, J, and Prichard, MN

Antimicrob Agents Chemother 2005. 49(3): 1039-1045


11. 56188 LR-13187; DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Antiadenovirus activities of several classes of nucleoside and nucleotide analogues

Naesens, L, Lenaerts, L, Andrei, G, Snoeck, R, Van Beers, D, Holy, A, Balzarini, J, and De Clercq, E

Antimicrob Agents Chemother 2005. 49(3): 1010-1016


12. 56189 LR-13188; DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Mechanism of Action of T-705 against Influenza Virus

Furuta, Y, Takahashi, K, Kuno-Maekawa, M, Sangawa, H, Uehara, S, Kozaki, K, Nomura, N, Egawa, H, and Shiraki, K

Antimicrob Agents Chemother 2005. 49(3): 981-986


13. 56190 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Human cytomegalovirus resistance to antiviral drugs

Gilbert, C and Boivin, G

Antimicrob Agents Chemother 2005. 49(3): 873-883


14. 56191 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire

Boehmann, Yannik, Enterlein, Sven, Randolf, Anke, and Muehlberger, Elke

Virology 2005. 332(1): 406-417

15. 56192 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

"Strong reasons make strong actions" - The antiviral efficacy of NS3/4A protease inhibitors

Lemon, SM, Yi, M, and Li, K

Hepatology 2005. 41(3): 671-674


16. 56193 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

The majority of the nucleotides in the top loop of the genomic 3' terminal stem loop structure are cis-acting in a West Nile virus infectious clone

Elghonemy, Salwa, Davis, William G, and Brinton, Margo A

Virology 2005. 331(2): 238-246

17. 56194 LR-13236; DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS-Coronavirus

Hoever, G, Baltina, L, Michaelis, M, Kondratenko, R, Baltina, L, Tolstikov, GA, Doerr, HW, and Cinatl, J Jr

J Med Chem 2005. 48(4): 1256-1259


18. 56195 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Differential Induction of Antiviral Effects Against West Nile Virus in Primary Mouse Macrophages Derived From Flavivirus-Susceptible and Congenic Resistant Mice by Alpha/Beta Interferon and Poly(I-C)

Pantelic, L., Sivakumaran, H., and Urosevic, N.

Journal of Virology 2005. 79(3): 1753-1764


19. 56196 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Novel [2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-d-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide) Derivatives with Anti-HIV-1 and Anti-Human-Cytomegalovirus Activity

de Castro, S, Lobaton, E, Perez-Perez, MJ, San-Felix, A, Cordeiro, A, Andrei, G, Snoeck, R, De Clercq, E, Balzarini, J, Camarasa, MJ, and Velazquez, S

J Med Chem 2005. 48(4): 1158-1168


20. 56197 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha

Likhitwitayawuid, K, Sritularak, B, Benchanak, K, Lipipun, V, Mathew, J, and Schinazi, RF

Nat Prod Res 2005. 19(2): 177-182


21. 56198 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Sense antiviral compound and method for treating ssrna viral infection

Iversen, Patrick L

PATENT: WO 2005013905 ISSUE DATE: 20050217

APPLICATION: 2004 PP: 81 pp.

ASSIGNEE: (Avi Biopharma, Inc. USA

22. 56199 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

A preparation of bicyclic imidazole derivatives, useful for the treatment of viral infections mediated by flaviviridae family of viruses

Schmitz, Franz Ulrich, Roberts, Christopher Don, Griffith, Ronald Conrad, Botyanszki, Janos, Gezginci, Mikail Hakan, Gralapp, Joshua Michael, Shi, Dong Fang, and Liehr, Sebastian JR

PATENT: WO 2005012288 ISSUE DATE: 20050210

APPLICATION: 2004 PP: 327 pp.

ASSIGNEE: (Genelabs Technologies, Inc USA

23. 56200 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Oseltamivir (Tamiflu(R)) and its potential for use in the event of an influenza pandemic

Ward, P, Small, I, Smith, J, Suter, P, and Dutkowski, R

J Antimicrob Chemother 2005. 55 Suppl 1: i5-i21


24. 56201 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Nuclear import in viral infections

Greber, UF and Fornerod, M

Current Topics in Microbiology and Immunology 2005. 285(Membrane Trafficking in Viral Replication): 109-138

25. 56202 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Considerations for Use of Recombinant Adenoviral Vectors: Dose Effect on Hepatic Cytochromes P450

Callahan, S. et al.

Journal of Pharmacology and Experimental Therapeutics 2005. 312(2): 492-501


26. 56203 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Comparing capsid assembly of primate lentiviruses and hepatitis B virus using cell-free systems

Lingappa, JR, Newman, MA, Klein, KC, and Dooher, JE

Virology 2005. 333(1): 114-123


27. 56204 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Reporter cell lines for the detection of herpes simplex viruses

Kung, Szu-Hao

Methods in Molecular Biology (Totowa, NJ, United States) 2005. 292(DNA Viruses): 73-81

28. 56205 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Agents and strategies in development for improved management of herpes simplex virus infection and disease

Kleymann, Gerald

Expert Opinion on Investigational Drugs 2005. 14(2): 135-161

29. 56206 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

An in vitro model of hepatitis C virion production

Heller, T, Saito, S, Auerbach, J, Williams, T, Moreen, TR, Jazwinski, A, Cruz, B, Jeurkar, N, Sapp, R, Luo, G, and Liang, TJ

Proc Natl Acad Sci U S A 2005. 102(7): 2579-2583


30. 56207 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Evaluation of anti-herpetic and antioxidant activities, and cytotoxic and genotoxic effects of synthetic alkyl-esters of gallic acid

Savi, Luciane A, Leal, Paulo C, Vicira, Tiago O, Rosso, Rober, Nunes, Ricardo J, Yunes, Rosendo A, Creczynski-Pasa, Tania B, Barardi, Celia RM, and Slmoes, Claudia MO

Arzneimittel Forschung 2005. 55(1): 66-75

31. 56208 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system

Shi, J, Du, J, Ma, T, Pankiewicz, KW, Patterson, SE, Tharnish, PM, McBrayer, TR, Stuyver, LJ, Otto, MJ, Chu, CK, Schinazi, RF, and Watanabe, KA

Bioorg Med Chem 2005. 13(5): 1641-1652


32. 56209 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Synthesis of 2-Amino-6-(4-[C-11]Methoxyphenylthio)9-[2-(Phosphonomethoxy)Ethyl]Purine Bis(2,2,2-Trifluoroethyl) Ester as a Novel Potential Pet Gene Reporter Probe for Hbv and Hsv-Tk in Cancers

Wang, J. et al.

Bioorganic & Medicinal Chemistry 2005. 13(2): 549-556


33. 56210 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(-) and S(+)-2-alpha-hydroxybenzylbenzimidazole)(2)Cl(2)] complexes

Gokce, M, Utku, S, Gur, S, Ozkul, A, and Gumus, F

Eur J Med Chem 2005. 40(2): 135-141


34. 56211 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Mashino, T, Shimotohno, K, Ikegami, N, Nishikawa, D, Okuda, K, Takahashi, K, Nakamura, S, and Mochizuki, M

Bioorg Med Chem Lett 2005. 15(4): 1107-1109


35. 56212 DMID-LS-87; PUBMED-DMID-3/1/2005 ; DMID-LSLOAD

Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects

Akihisa, T, Tokuda, H, Yasukawa, K, Ukiya, M, Kiyota, A, Sakamoto, N, Suzuki, T, Tanabe, N, and Nishino, H

J Agric Food Chem 2005. 53(3): 562-565


36. 56213 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD


Smits, Saskia L, Gerwig, Gerrit J, van Vliet, Arno LW, Lissenberg, Arjen, Briza, Peter, Kamerling, Johannis P, Vlasak, Reinhard, and de Groot, Raoul J

Journal of Biological Chemistry 2005. 280(8): 6933-6941

37. 56214 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae

Alymova, Irina V, Portner, Allen, Takimoto, Toru, Boyd, Kelli L, Babu, YSudhakara, and McCullers, Jonathan A

Antimicrobial Agents and Chemotherapy 2005. 49(1): 398-405

38. 56215 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Synthesis, X-Ray Crystal Structure Study, and Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-Aryl-Hydroxamic Acids

Barbaric, M. et al.

Journal of Medicinal Chemistry 2005. 48(3): 884-887


39. 56216 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Peptide inhibitors of coronavirus derived from Spike protein S2 subunit heptad repeat regions

Kim, Peter S, Eckert, Debra, Garsky, Victor M, Freidinger, Roger M, Geleziunas, Romas, and Pessi, Antonello

PATENT: WO 2005002500 ISSUE DATE: 20050113

APPLICATION: 2004 PP: 69 pp.

ASSIGNEE: (Merck & Co., Inc. USA and Istituto di Ricerche di Biologia Molecolare P. Angeletti, S. p. A.

40. 56217 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Stereoselective Synthesis and Antiviral Activity of Novel 4 '(Alpha)-Hydroxymethyl and 6 '(Alpha)-Methyl Dually Branched Carbocyclic Nucleosides

Kim, J., Choi, B., and Hong, J.

Bulletin of the Korean Chemical Society 2004. 25(12): 1812-1816


41. 56218 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Generation and Characterization of Recombinant Influenza a (H1n1) Viruses Harboring Amantadine Resistance Mutations

Abed, Y., Goyette, N., and Boivin, G.

Antimicrobial Agents and Chemotherapy 2005. 49(2): 556-559


42. 56219 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus

Oxford, John S, Balasingam, Shobana, Chan, Charlotte, Catchpole, Andrew, and Lambkin, Robert

Antiviral Chemistry & Chemotherapy 2005. 16(1): 13-21

43. 56220 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Methods of treating severe acute respiratory syndrome virus infections

Denison, Mark

PATENT: WO 2005011649 ISSUE DATE: 20050210

APPLICATION: 2004 PP: 20 pp.

ASSIGNEE: (Vanderbilt University, USA

44. 56221 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Characterization of H5n1 Influenza a Viruses Isolated During the 2003-2004 Influenza Outbreaks in Japan

Mase, M. et al.

Virology 2005. 332(1): 167-176


45. 56222 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Preparation of tetrahydrocarbazoles useful in the treatment of diseases associated with human papillomavirus infection

Boggs, Sharon Davis and Gudmundsson, Kristjan

PATENT: WO 2005005386 ISSUE DATE: 20050120

APPLICATION: 2004 PP: 70 pp.

ASSIGNEE: (Smithkline Beecham Corporation, USA

46. 56223 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Antiviral Sulfonamide Derivatives

Supuran, C. et al.

Mini-Reviews in Medicinal Chemistry 2004. 4(2): 189-200


47. 56224 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Preparation of substituted arylthioureas as inhibitors of viral replication

Phadke, Avinash, Quinn, Jesse, Ohkanda, Junko, Thurkauf, Andrew, Shen, Yiping, Liu, Cuixian, Chen, Dawei, and Li, Shouming

PATENT: WO 2005007601 ISSUE DATE: 20050127

APPLICATION: 2004 PP: 80 pp.

ASSIGNEE: (Achillion Pharmaceuticals, Inc. USA

48. 56225 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

The Novel L- and D-Amino Acid Derivatives of Hydroxyurea and Hydantoins: Synthesis, X-Ray Crystal Structure Study, and Cytostatic and Antiviral Activity Evaluations

Opacic, N. et al.

Journal of Medicinal Chemistry 2005. 48(2): 475-482


49. 56226 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Colorimetric lactate dehydrogenase (LDH) assay for evaluation of antiviral activity against bovine viral diarrhoea virus (BVDV) in vitro

Baba, Chiaki, Yanagida, Koichiro, Kanzaki, Tamotsu, and Baba, M

Antiviral Chemistry & Chemotherapy 2005. 16(1): 33-39

50. 56227 DMID-LS-87; SCIFINDER-DMID-3/1/2005 ; DMID-LSLOAD

Replicon cell culture system as a valuable tool in antiviral drug discovery against hepatitis C virus

Horscroft, Nigel, Lai, Vicky CH, Cheney, Wayne, Yao, Nanhua, Wu, Jim Z, Hong, Zhi, and Zhong, Weidong

Antiviral Chemistry & Chemotherapy 2005. 16(1): 1-12

51. 56228 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

The Human Papillomavirus E6 and E7 Inducible Oncogene, Hwapl, Exhibits Potential as a Therapeutic Target

Kuroda, M. et al.

British Journal of Cancer 2005. 92(2): 290-293


52. 56229 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Cooperativity of Actin and Microtubule Elements During Replication of Respiratory Syncytial Virus

Kallewaard, N., Boxena, A., and Crowe, J.

Virology 2005. 331(1): 73-81


53. 56230 DMID-LS-87; WOS-DMID-3/1/2005 ; DMID-LSLOAD

Polymorphism in the Genome of Non-Passaged Human Polyomavirus Bk: Implications for Cell Tropism and the Pathological Role of the Virus

Moens, U. and Van Ghelue, M.

Virology 2005. 331(2): 209-231


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