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Fungal Drugs in Development


OrganismDrug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Aspergillus spp.CombinationPfizerEraxis™ and Vfend™Anidulafungin and VoriconazolePhase IIICompleted
Aspergillus spp.Wall/Membrane DisruptorKaken Pharmaceutical Co.SPK-843SPA-S-843Phase IIIUnknown 121440
Aspergillus spp.Wall/Membrane DisruptorGilead SciencesNebulised Ambisome™Nebulised Liposomal Amphotericin BPhase IIICompleted 000096
Aspergillus spp.Wall/Membrane DisruptorBasilea PharmaceuticaIsavuconazoleASP9766; BAL-4815; BAL-8557(pro-drug)Phase IIIOngoing, Not Recruiting 416566
Candida spp.CombinationMethylGeneMGCD290 and Fluconazole MG-3290 and Fluconazole Phase IICompleted 496028
Candida spp.CombinationAlmirall, S.A.LAS41003LAS189962 and LAS189961Phase IICompleted
Candida spp.Enhance inflammatory responseAM-PharmaHuman LactoferrinhLF1-11Phase I/IITerminated 028450
Candida spp.Leucyl-tRNA synthetase inhibitorAnacor PharmaceuticalsAN-2718AN2718Phase ICompleted 471686
Candida spp.Sterol demethylase inhibitorPalau Pharma/GlaxoSmithKlineAlbaconazoleUR-9825, W-0027Phase IICompleted 024107
Candida spp.Sterol demethylase inhibitorViamet Pharmaceuticals, Inc.VT-1161 Phase IIRecruiting
Candida spp.Wall/Membrane DisruptorFerrer Internacional S.A.ArasertaconazoleR-isomer of SertaconazolePhase IICompleted
Candida spp.Wall/Membrane DisruptorPacgen BiopharmaceuticalsPAC-113PAC113Phase IICompleted
Cryptococcus spp.UnknownAlkermesLobradimilRMP-7Phase ICompleted
Cryptococcus spp.Wall/Membrane DisruptorKaken Pharmaceutical Co.SPK-843SPA-S-843Phase IIIUnknown 121440
Cryptococcus spp.Wall/Membrane DisruptorSchering-PloughGenaconazoleSCH 39304; SM-8668Phase ICompleted 007341
Pneumocystis jiroveciiCombinationGlaxoSmithKlineClindamycin and Primaquine Phase IIICompleted 000295
Pneumocystis jiroveciiCombinationGlaxoSmithKlineDapsone and Trimethoprim Phase IIICompleted 000310
Pneumocystis jiroveciiDNA Synthesis InhibitorImmtech Pharmaceuticals, IncPafuramidine maleate DB289; Prodrug of DB75Phase IIITerminated 022387
Pneumocystis jiroveciiSuccinate Dehydrogenase InhibitorGlaxoSmithKlineSitamaquineWR 6026Phase IICompleted 007904

Last Updated: October 2014