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Fungal Drugs in Development


OrganismDrug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Aspergillus spp.CombinationPfizerEraxis™ and Vfend™Anidulafungin and VoriconazolePhase 3Completed 549947
Aspergillus spp.Wall/Membrane DisruptorBasilea PharmaceuticaCresemba™ Isavuconazole; ASP9766; BAL-4815; BAL-8557(pro-drug)FDA Approved in 2015  416566
Aspergillus spp.Wall/Membrane DisruptorGilead Sciences; Nexstar PharmaceuticalsNebulised Ambisome™Nebulised Liposomal Amphotericin BPhase 2/3Recruiting 000096
Aspergillus spp.Wall/Membrane DisruptorKaken Pharmaceutical Co.SPK-843SPA-S-843Phase 3Unknown 121440
Candida spp.Cell wall synthesis inhibitorScynexis, Inc.SCY-078MK-3118Phase 2Recruiting 
Candida spp.CombinationAlmirall, S.A.LAS41003LAS189962 and LAS189961Phase 2Completed 
Candida spp.CombinationMethylGeneMGCD290 and Fluconazole MG-3290 and Fluconazole Phase 2Completed 496028
Candida spp.Enhance inflammatory responseAM-PharmaHuman LactoferrinhLF1-11Phase 1/2Terminated 028450
Candida spp.Leucyl-tRNA synthetase inhibitorAnacor PharmaceuticalsAN-2718 Phase 1Completed 471686
Candida spp.Sterol demethylase inhibitorPalau Pharma/GlaxoSmithKlineAlbaconazoleUR-9825, W-0027Phase 2Completed 024107
Candida spp.Sterol demethylase inhibitorViamet Pharmaceuticals, Inc.VT-1161 Phase 2Completed 
Candida spp.Wall/Membrane DisruptorFerrer Internacional S.A.ArasertaconazoleR-isomer of SertaconazolePhase 2Completed 008889
Candida spp.Wall/Membrane DisruptorPacgen BiopharmaceuticalsPAC-113 Phase 2Completed 
Cryptococcus spp.UnknownAlkermesLobradimilRMP-7Phase 1Completed 
Cryptococcus spp.Wall/Membrane DisruptorSchering-PloughGenaconazoleSCH 39304; SM-8668Phase 1Completed 007341
Cryptococcus spp.Wall/Membrane DisruptorKaken Pharmaceutical Co.; Proaparts srl SPK-843SPA-S-843Phase 3Unknown 121440
Pneumocystis jiroveciiCombinationGlaxoSmithKlineClindamycin and Primaquine Phase 3Completed 000295
Pneumocystis jiroveciiCombinationGlaxoSmithKlineDapsone and Trimethoprim Phase 3Completed 000310
Pneumocystis jiroveciiDNA Synthesis InhibitorImmtech Pharmaceuticals, IncPafuramidine maleate DB289; Prodrug of DB75Phase 3Terminated 022387
Pneumocystis jiroveciiSuccinate Dehydrogenase InhibitorGlaxoSmithKlineSitamaquineWR 6026Phase 2Completed 007904

Last Updated: April 2015