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HIV Drugs in Development


Drug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Biological Response Modifier Hemispherx; Rega Institute For Medical ResearchAtvogen™Ampligen, AMP, Poly(I)-Poly(C12U)Phase 2Completed 000136
Entry and Fusion InhibitorGenzyme CorporationAMD-070AMD-11070Phase 1/2Completed 495149
Entry and Fusion InhibitorTobira TherapeuticsCenicrivirocTBR-652; TAK-652Phase 2Completed 224423
Entry and Fusion InhibitorMerck (Schering-Plough)VicrivirocSCH-417690, SCH-D, VCVPhase 3Completed 210504
Entry and Fusion InhibitorTanox; Biogen Idec; Taimed BiologiesIbalizumabTNX-355; Hu5A8Phase 2Completed 209859
Entry and Fusion InhibitorIncyte CorporationINCB-009471INCB-9471Phase 2Completed 503495
Entry and Fusion InhibitorPfizerPF-00232798 Phase 2Completed 
Entry and Fusion InhibitorProgenics PharmaceuticalsPRO-140 Phase 2Ongoing 088103
Entry and Fusion InhibitorRapid PharmaceuticalsAdaptavirRAP101; monomeric d-Ala-peptide T-amide (mDAPTA)Phase 2Unknown 052004
Entry and Fusion InhibitorBristol-Myers SquibbFostemsavirBMS-626529; BMS-663068Phase 3Recruiting 
Histone Deacetylase (HDAC) InhibitorAbbott LabsEpival™; Depakote™Valproic acid, Divalproex sodium, VPAPhase 2Unknown 057177
Histone Deacetylase (HDAC) InhibitorMerckZolinza™Vorinostat; MK-0683, Suberoylanilide Hydroxamic Acid (SAHA)Phase 2Recruiting 186714
ImmunomodulatorPfizer (Wyeth)Ammonium Trichlorotellurate; OssireneAS-101Phase 2Completed 000042
ImmunomodulatorAmgenEnbrel™Etanercept; p75 TNFR-Fc fusion proteinPhase 1Completed 
ImmunomodulatorHoffmann-La RochePegasys™PEG IFN alpha-2aPhase 2Completed 
ImmunomodulatorGlaxoSmithKlineTucaresol Phase 2Completed 029800
Integrase InhibitorBoehringer IngelheimBI-224436 Phase 1Completed 566575
Integrase InhibitorGlaxoSmithKlineCabotegravirGSK1265744; S-265744Phase 2Completed 
Integrase InhibitorGlaxoSmithKlineGSK1247303 Phase 1Terminated 
Integrase InhibitorJapan Tobacco Inc.; Gilead SciencesElvitegravirEVG, GS-9137, JTK-303Phase 2Completed 241767
Integrase InhibitorGilead SciencesGS-9883 Phase 2Recruiting 
Maturation InhibitorBristol-Myers SquibbBMS-955176 Phase 2Completed 
Maturation InhibitorGlaxoSmithKlineGSK2838232 Phase 1Suspended 
MicrobicideMyrexis, Inc.; Panacos PharmaceuticalsBevirimatBVM, PA-457; MPC-4326Phase 2Completed 028530
MicrobicideStarpharmaVivaGel™SPL-7013 gelPhase 1/2Completed 223863
MicrobicideUniroyal/Crompton Corp/BiosynUC781 Phase 1Completed 029940
MicrobicideGilead SciencesTenofovir gel (GS-1278)GS-1278; PMPA gelPhase 3Recruiting 021800
MicrobicideProcept/Interneuron/IndevusPro-2000PRO-2000/5Phase 3Completed 032942
MicrobicideTibotec Pharmaceuticals; Janssen; Johnson & JohnsonDapivirineTMC-120Phase 3Unknown 105293
MicrobicidePopulation Council Center for Biomedical ResearchCarraguard™Carragaen, Carrageenan gum, Carrageenin, Irish moss extract, PC-515Phase 3Completed 000100
MicrobicideReprotect, Inc.BufferGel™Carbomer 974P, Carbopol 974P, Carbopol polymerPhase 2Completed 180064
NNRTIGlaxoSmithKlineGSK2248761IDX-899Phase 2Terminated 485324
NNRTIMerck & CoDoravirineMK-1439Phase 3Not Yet Recruiting 525576
NNRTIBoehringer IngelheimBILR 355 BS Phase 2Terminated 212773
NNRTIKainos MedicineKM-023 Phase 1Completed 
NNRTIPfizerLersivirineUK453,061Phase 2Terminated 497274
NRTIChimerixCMX-157 Hexadecyloxypropyl ester of TenofovirPhase 1Completed 477886
NRTIAvexaApricitabine(-)-Dotc; ATC; AVX-754; BCH-10618; BCH-10619; BCH-10652; SPD-754Phase 3Withdrawn 058066
NRTIRFS Pharma; Biochem Pharma; Triangle Pharmaceuticals; Gilead SciencesAmdoxovirDAPDPhase 2Withdrawn 005431
NRTIAchillion Pharmaceuticals; Vion PharmaceuticalsElvucitabineACH-126443; beta-L-Fd4CPhase 2Completed 060327
NRTIOncolys BioPharma; Brisol-Myers SquibbFestinavir4'-ethynyl-d4T; BMS-986001; OBP-601Phase 2bTerminated 209894
NRTIGilead SciencesGS-7340Tenofovir Alafenamide (Prodrug of tenofovir)Phase 3Recruiting 046774
NRTIPharmasset/Dupont Pharmaceuticals; VionReverset ™Dexelvucitabine; DFCPhase 2Terminated 000572
NRTIGlaxo Wellcome; GlaxoSmithKline; Pharmasset, Inc.RacivirRCV; (+/-)FTCPhase 2Completed 005245
NRTIKoronisKP-1212 KP-1461(prodrug of KP-1212)Phase 2Terminated 293211
Protease InhibitorConcert PharmaceuticalsCTP-298C-10276, C-10297, C-10299Phase 1Completed 
Protease InhibitorTibotec PharmaceuticalsTMC-310911 Phase 2Completed 483146
UnidentifiedMerckMK-1972 Phase 1Terminated 

Last Updated: April 2015