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HIV Drugs in Development


Drug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Biological Response Modifier Hemispherx; Rega Institute For Medical ResearchAtvogen™Ampligen, AMP, Poly(I)-Poly(C12U)Phase IICompleted 000136
Entry and Fusion InhibitorsRapid PharmaceuticalsAdaptavirRAP101; monomeric d-Ala-peptide T-amide (mDAPTA)Phase IIUnknown 052004
Entry and Fusion InhibitorsGenzyme CorporationAMD-070AMD-11070Phase I/IICompleted 495149
Entry and Fusion InhibitorsSangamo BioSciencesSB-728-TCCR5-specific zinc finger protein nucleasePhase I/IIOngoing, Not Recruiting
Entry and Fusion InhibitorsBristol-Myers SquibbBMS-663068BMS-626529Phase IICompleted
Entry and Fusion InhibitorsTobira TherapeuticsCenicrivirocTBR-652; TAK-652Phase IICompleted 224423
Entry and Fusion InhibitorsTanox; Biogen Idec; Taimed BiologiesIbalizumabTNX-355; Hu5A8Phase IIInvitation Only 209859
Entry and Fusion InhibitorsSchering-PloughVicrivirocSCH-417690, SCH-D, VCVPhase IIICompleted 210504
Entry and Fusion InhibitorsProgenics PharmaceuticalsPRO-140 Phase IIOngoing 088103
Entry and Fusion InhibitorsPfizerPF-00232798 Phase IICompleted
Entry and Fusion InhibitorsIncyte CorporationINCB-009471INCB-9471Phase IICompleted 503495
Histone Deacetylase (HDAC) InhibitorMerckZolinza™Vorinostat; MK-0683, Suberoylanilide Hydroxamic Acid (SAHA)Phase IIRecruiting 186714
Histone Deacetylase (HDAC) InhibitorAbbott LabsEpival™; Depakote™Valproic acid, Divalproex sodium, VPAPhase IIRecruitment Unknown 057177
Integrase Inhibitor Japan Tobacco Inc.; Gilead Sciences; GlaxoSmithKlineElvitegravirEVG, GS-9137, JTK-303NDA June 2012Rejected 241767
Integrase Inhibitor GlaxoSmithKlineGSK1265744S-265744Phase IIOngoing, Not Recruiting
Integrase Inhibitor Boehringer IngelheimBI-224436 Phase IWithdrawn
Integrase Inhibitor GlaxoSmithKlineGSK1247303 Phase ITerminated
Maturation InhibitorGlaxoSmithKlineGSK2838232 Phase IOngoing, Not Recruiting
MicrobicidePopulation Council Center for Biomedical ResearchCarraguard™Carragaen, Carrageenan gum, Carrageenin, Irish moss extract, PC-515Phase IIICompleted 000100
MicrobicideGilead SciencesTenofovir gel (GS-1278)GS-1278; PMPA gelPhase IIIRecruiting 021800
MicrobicidePanacos PharmaceuticalsBevirimatBVM, PA-457; MPC-4326Phase IICompleted 028530
MicrobicideReprotect, Inc.BufferGel™Carbomer 974P, Carbopol 974P, Carbopol polymerPhase IICompleted 180064
MicrobicideStarpharmaVivaGel™SPL-7013 gelPhase I/IICompleted 223863
MicrobicideTibotec Pharmaceuticals; Janssen; Johnson & JohnsonDapivirineTMC-120Phase IIIRecruiting 105293
MicrobicideProcept/Interneuron/IndevusPro-2000PRO-2000/5Phase IIICompleted 032942
MicrobicideUniroyal/Crompton Corp/BiosynUC781 Phase ICompleted 029940
NNRTIKainos MedicineKM-023 Phase ICompleted
NNRTIBoehringer IngelheimBILR 355 BS Phase IITerminated 212773
NNRTIGlaxoSmithKlineGSK2248761IDX-899Phase IITerminated 485324
NNRTIPfizerLersivirineUK453,061Phase IITerminated 497274
NNRTIMerck & CoDoravirineMK-1439Phase IIRecruiting 525576
NRTIChimerixCMX-157 Hexadecyloxypropyl ester of TenofovirPhase ICompleted 477886
NRTIPharmasset/Dupont Pharmaceuticals; VionReverset ™Dexelvucitabine; DFCPhase IITerminated 000572
NRTIRFS Pharma; Biochem Pharma; Triangle Pharmaceuticals; Gilead SciencesAmdoxovirDAPDPhase IIOngoing 005431
NRTIOncolys BioPharma; Brisol-Myers SquibbFestinavir4'-ethynyl-d4T; BMS-986001; OBP-601Phase IIbOngoing 209894
NRTIGilead SciencesGS-7340Tenofovir Alafenamide (Prodrug of tenofovir)Phase IIIRecruiting 046774
NRTIGlaxo Wellcome; GlaxoSmithKline; Pharmasset, Inc.RacivirRCV; (+/-)FTCPhase IICompleted 005245
NRTIAchillion Pharmaceuticals; Vion PharmaceuticalsElvucitabineACH-126443; beta-L-Fd4CPhase IICompleted 060327
NRTIAvexaApricitabine(-)-Dotc; ATC; AVX-754; BCH-10618; BCH-10619; BCH-10652; SPD-754Phase IIIWithdrawn 058066
NRTIKoronisKP-1212 KP-1461(prodrug of KP-1212)Phase IITerminated 293211
Other Immune ModulatorAmgenEnbrel™Etanercept; p75 TNFR-Fc fusion proteinPhase ICompleted
Other Immune ModulatorBioMASAS-101Ammonium TrichlorotelluratePhase ICompleted 000042
Other Immune ModulatorGlaxoSmithKlineTucaresol Phase IICompleted 029800
Other Immune ModulatorHoffmann-La RochePegasys™PEG IFN alpha-2aPhase II/IIIOngoing
Pharmacokinetic EnhancerGilead SciencesCobicistatGS-9350NDA June 2012Rejected
Protease InhibitorTibotec PharmaceuticalsTMC-310911 Phase IICompleted 483146
Protease InhibitorConcert PharmaceuticalsCTP-298C-10276, C-10297, C-10299Phase ICompleted
UnidentifiedMerck & CoMK-1972 Phase ITerminated

Last Updated: January 2014