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TB Drugs in Development


Drug ClassCompanyDrug NameAlt NameDrug StatusNotesAIDS#
Bactericidal-ATP Synthase InhibitorJohnson & JohnsonBedaquilineTMC-207; R207910Phase IIINot Yet Recruiting 222088
Cell Wall Synthesis InhibitorSequellaSQ-109 Phase IIRecruiting 207396
DNA Replication Inhibitor/TB Cell division inhibitorParke-Davis; Kyorin Pharm; PfizerTequin™Gatifloxacin; GTFX; BMS-206584; AM-1155; CG 5501; PD-135432; GATPhase IIIRecruitment Unknown 044913
DNA Replication Inhibitor/TB Cell division inhibitorBayerFlagyl™Metronidazole; Bayer 5360; Methronidazole; MTZ; RP 8823; SC 10295; WagitranPhase IICompleted 007953
DNA Replication Inhibitor/TB Cell division inhibitorDaiichi Pharm; Sanofi-Aventis; Ortho-McneilLevofloxacinS-(-)-Ofloxacin; DR-3355; RWJ-25213; Cravit; L-Ofloxacin; LVX; Levaquin; TavanicPhase IIIRecruiting 002307
DNA Replication Inhibitor/TB Cell division inhibitorBayer; Schering-Plough MoxifloxacinMXFX; BAY 12-8039Phase IIIOngoing, Not Recruiting 070017
Intracellular NO ReleasePathogenesis Corp; ChironPA-824 Phase IIOngoing, Not Recruiting 007331
Mycolic acid biosynthesis inhibitorOtsuka PharmDelamanidOPC-67683Phase IIIRecruiting 182259
Protein Synthesis Inhibitor/TB grwoth InhibitorPharmacia & Upjohn, Inc.; PfizerSutezolidPNU-100480; PF-02341272Phase IICompleted 045415
Protein Synthesis Inhibitor/TB grwoth InhibitorAstrazenecaAZD-5847 Phase IIRecruiting
Protein Synthesis Inhibitor/TB grwoth InhibitorsPharmacia & Upjohn, Inc.; PfizerZyvox™Linezolid; PNU-100766Phase IIOngoing, Not Recruiting 070944
TB Cell division inhibitorMarion Merrel Dow; Sanofi-AventisPriftin™Rifapentine; MDL 473; RPE; RPT; Cyclopentyl rifampin; DL 473; R 77-3Phase IIIOngoing, Not Recruiting 007686

Last Updated: October 2014